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Despite the principal role of high-tech clusters in local planning practice and research, their location and sectoral typology at the granular level have been rarely studied. This study explores the location of U.S. high-tech clusters at a micro-scale by employing firm-level data sets and spatial statistics and examines their sectoral typology using market concentration indices in 52 large U.S regions. The majority (80 %) of the 627 tech clusters we identify have multiple dominant tech industries or are specialized in professional services. Furthermore, while clusters form the major regional hubs for the high-tech economy, they are home to a very small share (7 %, on average) of regional population. U.S. regions also have widely diverse spatial patterns of high-tech clusters; although some regions have scattered clusters, the New York and Northern California high-tech booming regions have clusters concentrated in central business districts (CBDs). Last, U.S. high-tech clusters and the overall high-tech economy are strongly shaped by the location and performance of professional services, i.e., consulting, legal, computer, engineering, and architectural services. • Our international contribution is a novel approach and innovative methodology on quantifying the finest scale location of high-tech clusters. • Most of the 627 identified tech clusters have multiple dominant tech industries or are specialized in professional services. • High-tech clusters are the major regional hubs for the high-tech economy, while home to only 7 percent (on average) of regional population. • U.S. high-tech clusters mostly depend on professional services, i.e., consulting, legal, computer, engineering, and architectural services. • Central business districts (CBDs) and major airport are home to cluster attention to the formation of "Aerotropolis" in the knowledge economy. [ABSTRACT FROM AUTHOR]