1. Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children.
- Author
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Sanogo B, Ouermi AS, Barro M, Millogo A, Ouattara ABI, Abdoul Salam O, and Nacro B
- Subjects
- Adolescent, CD4 Lymphocyte Count, Cambodia, Cameroon, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Sensitivity and Specificity, Tuberculin Test, Tuberculosis immunology, Vietnam, HIV Infections microbiology, Interferon-gamma Release Tests methods, Mycobacterium tuberculosis immunology, T-Lymphocytes immunology, Tuberculosis diagnosis
- Abstract
Objective: Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children., Method: Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB., Results: Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%., Conclusion: QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2020
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