1. Antimicrobial isopropenyl-dihydrofuranoisoflavones from Crotalaria lachnophora.
- Author
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Awouafack MD, Spiteller P, Lamshöft M, Kusari S, Ivanova B, Tane P, and Spiteller M
- Subjects
- Anti-Bacterial Agents pharmacology, Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Cameroon, Escherichia coli drug effects, Fungi drug effects, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Isoflavones chemistry, Klebsiella pneumoniae drug effects, Microbial Sensitivity Tests, Molecular Structure, Anti-Infective Agents isolation & purification, Crotalaria chemistry, Isoflavones isolation & purification, Isoflavones pharmacology, Plants, Medicinal chemistry
- Abstract
Two new isopropenyl-dihydrofuranoisoflavones exhibiting antimicrobial properties have been isolated along with eight known compounds from the Cameroonian medicinal plant Crotalaria lachnophora. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and high-resolution mass spectrometry as 7,2',4'-trihydroxy-5''-isopropenyl-4'',5''-dihydrofurano[2'',3'':5,6]isoflavone (1) and 4,8-dihydroxy-2-isopropenyl-2,3-dihydro-5H-[1]benzofuro[2,3-b]furo[3,2-g]chromen-5-one (2). The CH(2)Cl(2)/MeOH (1:1) extract and the compounds isolated were subjected to in vitro antimicrobial assays against a panel of pathogenic microorganisms, including Gram-positive and Gram-negative bacteria and fungi. The new compounds, named lachnoisoflavones A (1) and B (2), showed moderate inhibitory activities against Escherichia coli and Klebsiella pneumoniae.
- Published
- 2011
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