1. Cameroonemide A: a new ceramide from Helichrysum cameroonense.
- Author
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Antoine KZ, Hussain H, Dongo E, Kouam SF, Schulz B, and Krohn K
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Cameroon, Ceramides chemistry, Ceramides pharmacology, Microbial Sensitivity Tests, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Anti-Bacterial Agents isolation & purification, Bacillus megaterium drug effects, Ceramides isolation & purification, Helichrysum chemistry
- Abstract
From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NMR and HR-EI-MS spectral data. The remaining four known compounds were identified by comparing their spectroscopic data with those reported in the literature as kaurenoic acid (2), 3-acetyloxykaurenoic acid (3), beta-sitosterol (4), and beta-sitosterol glucopyranoside (5). Preliminary studies showed that 3-acetyloxykaurenoic acid (3) inhibited the alga Chlorella fusca, while kaurenoic acid (2) showed strong antibacterial activity against Bacillus megaterium.
- Published
- 2010
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