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1. Cross-Clade Reactivity of HIV-1—Specific T-Cell Responses in HIV-1—Infected Individuals From Botswana and Cameroon.

Author

Gupta, Swati B., Mast, Christopher T., Wolfe, Nathan D., Novitsky, Vlad, Dubey, Sheri A., Kallas, Esper G., Schechter, Mauro, Mbewe, Bernard, Vardas, Eftyhia, Pitisuttithum, Punee, Burke, Donald, Freed, Dan, Mogg, Robin, Coplan, Paul M., Condra, Jon H., Long, Romnie S., Anderson, Kiersten, Casimiro, Danilo R., Shiver, John W., and Straus, Walter L.

Subjects
*IMMUNE response, *T cells, *HIV infections, *ANTIVIRAL agents, *VIRAL proteins
Abstract

The article compares anti-HIV-1 T-cell immune responses among unvaccinated individuals from Botswana and Cameroon results infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef proteins were the same when compared with countries including Brazil, Thailand, South Africa, Malawi and the United States. Overall, 93 percent of individuals responded to either all 3 clade Gag or all 3 clade Nef proteins in Botswana and 98 percent responded to clade B Gag and/or Nef proteins in Cameroon.

Published
2006
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