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1. Differential influence of race and environment on indeterminate reactivities to non-treponemal and treponemal antigens by immuno-chromatographic dual syphilis rapid test.

Author

Mbopi-Keou FX, Kalla GCM, Voundi EV, Jenabian MA, Mboumba Bouassa RS, Talla F, Angwafo FF 3rd, and Belec L

Subjects
Black People, Cameroon, False Positive Reactions, France, Humans, Prospective Studies, Syphilis immunology, White People, Antigens, Bacterial immunology, Syphilis diagnosis, Syphilis Serodiagnosis methods, Treponema pallidum immunology
Abstract

Introduction: Syphilis rapid test results may be influenced by numerous environmental and genetic factors., Methods: The proportion of false positive syphilis non-treponemal (NT) and treponemal (T) test results using immuno-chromatographic dual syphilis rapid test on serum from Cameroonian blacks (n=103) versus French blacks (n=104) or French caucasians (n=51), all HIV-negative and free of clinical syphilis, was examined., Results: Black individuals in Cameroon had a significantly higher frequency of false positive NT or T tests than black individuals in France. black individuals in France had a higher frequency of indeterminate NT tests as compared to caucasians in France., Conclusion: Both racial and environmental factors may affect immuno-chromatographic dual syphilis rapid testing., Competing Interests: The authors declare no competing interests.

Published
2019
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