1. Pycnanthulignenes A-D, antimicrobial cyclolignene derivatives from the roots of Pycnanthus angolensis.
- Author
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Nono EC, Mkounga P, Kuete V, Marat K, Hultin PG, and Nkengfack AE
- Subjects
- Anti-Infective Agents chemistry, Anti-Infective Agents pharmacology, Cameroon, Isoflavones chemistry, Isoflavones isolation & purification, Lignans chemistry, Lignans pharmacology, Methicillin-Resistant Staphylococcus aureus drug effects, Microbial Sensitivity Tests, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Roots chemistry, Anti-Infective Agents isolation & purification, Drug Resistance, Bacterial drug effects, Lignans isolation & purification, Myristicaceae chemistry
- Abstract
Investigation of the constituents of Pycnanthus angolensis roots has resulted in the isolation of four new cyclolignene derivatives, named pycnanthulignene A (1), pycnanthulignene B (2), pycnanthulignene C (3), and pycnanthulignene D (4), and six known compounds, 4,5-dimethoxy-3',4'-methylenedioxy-2,7'-cycloligna-7,7'-diene, 2,7-dimethoxy-3,6-dimethylnaphthalene, 4'-methoxy-4,5-methylenedioxy-2,7'-cyclolign-7-ene, genkwainin, 8-hydroxykanzakiflavone-2, and formononetin. The structures of these compounds were established using spectroscopic methods. Compounds 1 and 3 showed significant antimicrobial activities against a panel of drug-resistant pathogens.
- Published
- 2010
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