1. Schweinfurthins I and J from Macaranga schweinfurthii.
- Author
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Klausmeyer P, Van QN, Jato J, McCloud TG, and Beutler JA
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Cameroon, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Plant Leaves chemistry, Stilbenes chemistry, Stilbenes pharmacology, Antineoplastic Agents, Phytogenic isolation & purification, Euphorbiaceae chemistry, Plants, Medicinal chemistry, Stilbenes isolation & purification
- Abstract
Demand for the experimental antineoplastic agent schweinfurthin A, for developmental testing, prompted a re-collection of leaf material of Macaranga schweinfurthii from the original collection site in Cameroon. During chromatographic purification of the organic solvent extract, analytical UPLC-PDA-TOFMS of stilbene-enriched fractions revealed the presence of six known schweinfurthins and two previously unknown stilbenes. The structures of these new compounds, schweinfurthins I and J (1 and 2), were elucidated by 1D- and 2D-NMR techniques.
- Published
- 2010
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