1. Triterpene saponins from the roots of Acacia senegal (L.) Willd.
- Author
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Tchoukoua A, Douanla MH, Ariefta NR, Yoshida J, Ito Y, Ngadjui BT, and Shiono Y
- Subjects
- Animals, Antineoplastic Agents, Phytogenic isolation & purification, Cameroon, Cell Line, Tumor, Cell Survival, Drug Screening Assays, Antitumor, Molecular Structure, Phytochemicals isolation & purification, Phytochemicals pharmacology, Plant Roots chemistry, Rats, Saponins isolation & purification, Triterpenes isolation & purification, Acacia chemistry, Antineoplastic Agents, Phytogenic pharmacology, Saponins pharmacology, Triterpenes pharmacology
- Abstract
Six new triterpenoid saponins, named senegalosides A-F (1-6) were isolated from the seedpods and roots of Acacia senegal (Mimosaceae). Their structures were elucidated using 1D and 2D-NMR spectroscopic analysis and mass spectrometry. Compound 1 possesses an unusual sapogenin, 3β-hydroxy-21-oxo-olean-12-en-28-oic acid (machaeric acid), and was reported here in its natural form for the first time within the genus Acacia. Senegaloside A is the first example of a machaeric-type triterpenoid glycoside in the plant kingdom. The cytotoxic effect of isolated saponins was evaluated on the H4IIE rat hepatoma cell line. As a result, compounds 1, 3-6 were not significantly cytotoxic to H4IIE cells even at 200 μM. Compound 2 was suppressed cell viability at 50-200 μM., (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Published
- 2021
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