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We tested theories of links between musical expertise and language ability in a sample of 6- to 9-year-old children. Language ability was measured with tests of speech perception and grammar. Musical expertise was measured with a test of musical ability that had 3 subtests (melody discrimination, rhythm discrimination, and long-term memory for music) and as duration of music training. Covariates included measures of demographics, general cognitive ability (IQ, working memory), and personality (openness-to-experience). Music training was associated positively with performance on the grammar test, musical ability, IQ, openness, and age. Musical ability predicted performance on the tests of speech perception "and" grammar, as well as IQ, working memory, openness, and age. Regression analyses--with other variables held constant--revealed that language abilities had significant partial associations with musical ability and IQ but not with music training. Rhythm discrimination was a better predictor of language skills compared with melody discrimination, but memory for music was equally good. Bayesian analyses confirmed the results from the standard analyses. The implications of the findings are threefold: (a) musical ability predicts language ability, and the association is independent of IQ and other confounding variables; (b) links between music and language appear to arise primarily from preexisting factors and not from formal training in music; and (c) evidence for a special link between rhythm and language may emerge only when rhythm discrimination is compared with melody discrimination.

We sought to clarify whether the positive association between music lessons and reading ability is explained better by shared resources for processing pitch and temporal information, or by general cognitive abilities. Participants were native and nonnative speakers of English with varying levels of music training. We measured reading ability (comprehension and speed), music-perception skills (melody and rhythm), general cognitive ability (nonverbal intelligence, short-term memory, and working memory), and socioeconomic status (SES; family income, parents' education). Reading ability was associated positively with music training, English as a native language, and general cognitive ability. The association between reading and music training was significant after SES, native language, and music-perception skills were controlled. After general cognitive abilities were held constant, however, there was no longer an association between reading and music training. These findings suggest that the association between reading ability and music training is a consequence of general cognitive abilities.

Rationale: Epidemic Pseudomonas aeruginosa (PA) plays an important role in cystic fibrosis (CF) lung disease. A novel strain, the 'Prairie Epidemic Strain' (PES), has been identified in up to 30% of patients in Prairie-based Canadian CF centres.Objective: To determine the incidence, prevalence and long-term clinical impact of PES infection.Methods: A cohort of adults with CF was followed from 1980 to 2014 where bacteria isolated from clinical encounters were prospectively collected. Strain typing was performed using pulse-field gel electrophoresis and multilocus sequence typing. Patients were divided into one of four cohorts: no PA, transient PA, chronic PA with unique strains and chronic PES. Proportional Cox hazard and linear mixed models were used to assess for CF-associated respiratory death or transplantation, and rates of %FEV1 and body mass index (BMI) decline.Results: 274 patients (51.7% male) were analysed: 44--no PA, 29--transient PA, 137--unique PA, 64--PES. A total of 92 patients (33.6%) died or underwent lung transplantation (2423.0 patient-years). PES infection was associated with greater risk of respiratory death or lung transplant compared with the no PA group (aHR, 3.94 (95% CI 1.18 to 13.1); p=0.03) and unique PA group (aHR, 1.75 (95% CI 1.05 to 2.92) p=0.03). Rate of lung function decline (%FEV1 predicted) was greatest in the PES group (1.73%/year (95% CI 1.63% to 1.82%); p<0.001). BMI improved over time but at an attenuated rate in the PES group (p=0.001).Conclusions: Infection with PES was associated with increased patient morbidity through three decades and manifested in an increased risk of respiratory death and/or lung transplantation. [ABSTRACT FROM AUTHOR]