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This research examined the simultaneous influences of emotional intelligence, adjustment to university, authoritative versus other parenting style, and high school average on first year university students' grade point average (GPA) via structural equation modeling. The participants were 299 first year students from the social science faculty at Laurentian University, Canada. The sample was comprised of 86 males (28.7%) and 213 females (71%); most students (96.7%) were between the ages of 17 and 23. The results showed that high school average had a direct influence on first year university GPA. Emotional Intelligence was not directly associated with first year university GPA, but it was significantly associated with adjustment to university which in turn was significantly associated with the first year GPA. This tends to suggest that the influence of emotional intelligence on academic achievement may be mediated by adjustment to university. Furthermore, parenting style (authoritative versus other) had a significant influence on adjustment to university but not on emotional intelligence and university GPA. Students who came from families with authoritative parenting styles tended to be better adjusted than students who came from families with other parenting styles (authoritarian and permissive). Problem behaviors such as alcohol use, academic dishonesty and academic procrastination were found to have a negative influence on university GPA and adjustment to university. In conclusion, emotional intelligence and an authoritative parenting style are influential in enhancing adjustment to university which in turns affects academic achievement in university.

This article reports on a qualitative case study involving pedagogical innovations grounded in culturally and linguistically inclusive approaches to curriculum. In this project, kindergarten children were supported in collaboratively authoring Dual Language Identity Texts. Our findings suggest that as family and teacher conceptions of literacy were extended beyond traditional monolingual print-based literacy, home literacies associated with complex transnational and transgenerational communities of practice were legitimated through their inclusion within the school curriculum. This process invited family members to take up roles as expert partners in children's biliteracy development. Further, conditions were fostered for parents to consider and articulate their beliefs and values vis-a-vis their children's multiliterate practice and participation within these multiple, transnational communities. (Contains 1 figure and 13 notes.)

Youth from single-parent families report lower educational aspirations than those from two-parent families. This study explored the influence of background factors (gender, grade, parental education and SES), parental involvement with education, academic self-concept, and peer influences on educational aspirations. The participants were Canadian adolescents; 2751 from two parent and 681 from single-parent families. ANOVA results showed that adolescents from single-parent families scored significantly lower than adolescents from intact families on educational aspirations, and other predictor variables. Hierarchical regression analysis showed that the pattern of relationships between educational aspirations and other factors was very similar for adolescents from both types of families; namely academic self-concept significantly predicted educational aspirations. The family involvement and background factors predicted educational aspirations via academic self-concept. Having academically oriented peers was especially beneficial to adolescents from single-parent families. Implications for intervention programs are discussed.

Structural equation modeling of data from 4,034 Canadian adolescents yielded a factor composed of academic achievement, extracurricular reading, attitudes toward school and homework, and parental educational expectations that predicted 76% of variance in educational aspirations. Positive family climate and parental involvement fostered a positive academic self-schema. (Contains 33 references.) (SK)

The Ancestors of the Aboriginal people of Saskatchewan, specifically Saskatoon and the surrounding area, have lived on what is now Treaty 6 territory since time began. Like other cultures around the world, each Aboriginal group has its own distinct culture, language, spiritual beliefs and practices. In a local and contemporary context, these are the times to actively reflect on the longevity of the treaties that are meant to last "as long as the grass grows, the sun shines and the rivers flow." In the last two decades, the City of Saskatoon has been involved in many various facets of building bridges among Aboriginal People, recent newcomers and the mainstream population through different avenues such as recreation, culture and business. [ABSTRACT FROM AUTHOR]

Purpose: The Phase 3 ENDEAVOUR study evaluated revusiran, an investigational RNA interference therapeutic targeting hepatic transthyretin (TTR) production, for treating cardiomyopathy caused by hereditary transthyretin-mediated (hATTR) amyloidosis., Methods: Patients with hATTR amyloidosis with cardiomyopathy were randomized 2:1 to receive subcutaneous daily revusiran 500 mg (n = 140) or placebo (n = 66) for 5 days over a week followed by weekly doses. Co-primary endpoints were 6-min walk test distance and serum TTR reduction., Results: Revusiran treatment was stopped after a median of 6.71 months; the study Sponsor prematurely discontinued dosing due to an observed mortality imbalance between treatment arms. Eighteen (12.9%) patients on revusiran and 2 (3.0%) on placebo died during the on-treatment period. Most deaths in both treatment arms were adjudicated as cardiovascular due to heart failure (HF), consistent with the natural history of the disease. A post hoc safety investigation of patients treated with revusiran found that, at baseline, a greater proportion of those who died were ≥ 75 years and showed clinical evidence of more advanced HF compared with those who were alive throughout treatment. Revusiran pharmacokinetic exposures and TTR lowering did not show meaningful differences between patients who died and who were alive. Revusiran did not deleteriously affect echocardiographic parameters, cardiac biomarkers, or frequency of cardiovascular and HF hospitalization events., Conclusions: Causes for the observed mortality imbalance associated with revusiran were thoroughly investigated and no clear causative mechanism could be identified. Although the results suggest similar progression of cardiac parameters in both treatment arms, a role for revusiran cannot be excluded., Clinical Trial Registration: NCT02319005.