1. First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy: GENEPI-II.
- Author
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De Ruysscher D, Severin D, Barnes E, Baumann M, Bristow R, Grégoire V, Hölscher T, Veninga T, Polański A, van Veen EB, Verfaillie C, Heeren G, Damaraju S, Just U, and Haustermans K
- Subjects
- Aged, Biomarkers, Tumor genetics, Breast Neoplasms genetics, Breast Neoplasms radiotherapy, Canada, Europe, Female, Head and Neck Neoplasms genetics, Head and Neck Neoplasms radiotherapy, Humans, Lung Neoplasms genetics, Lung Neoplasms radiotherapy, Lymphoma genetics, Lymphoma radiotherapy, Male, Meningioma genetics, Meningioma radiotherapy, Middle Aged, Radiation Injuries, Radiotherapy Dosage, Radiation Tolerance genetics, Radiotherapy adverse effects, Tissue Banks organization & administration
- Abstract
Background: Identifying the most radiosensitive patient group would have huge clinical implications., Methods: A tissue bank containing skin fibroblasts, whole blood, lymphocytes, plasma and lymphoblastoid cell lines from clinically radiation hypersensitive patients was established from patients in Europe and Canada. Over-reacting individuals had CTCAE3.0 severe acute side effects grade 2 or more occurring at very low radiation doses where these side effects are unexpected or grade 3-4 lasting more than 4 weeks after the end of radiotherapy and/or requiring surgical intervention at any time or severe late side effects grade 3-4., Results: Eleven patients have been identified with a mean age of 61.6±8.5 years (range 49-74). Two patients were male, 9 female. One patient had non-small cell lung cancer, 6 breast cancer, 2 head and neck cancer, one lymphoma and one meningioma. The mean follow-up time after radiotherapy was 1658±1048 days (range 84-3752)., Conclusions: The establishment of an international tissue bank of the rare group of patients with extreme hypersensitivity to radiotherapy was proven to be feasible and should enable in-depth molecular studies., (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2010
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