1. EVEN VISITING SCIENTISTS COULD MAKE DISCOVERIES IN MONTREAL.
- Author
-
Lázár G
- Subjects
- Canada, Gadolinium history, Gadolinium pharmacology, History, 20th Century, Humans, Hungary, Immune System metabolism, Immune System pathology, Academies and Institutes history, Kupffer Cells drug effects, Kupffer Cells metabolism, Kupffer Cells pathology, Leadership, Mentors, Mononuclear Phagocyte System drug effects, Mononuclear Phagocyte System metabolism, Mononuclear Phagocyte System pathology, Research history
- Abstract
This publication summarizes the scientific adventure with Professor Selye, and focuses on the specific effect of rare metal salts on reticuloendothelial functions. Rare earth metal ions markedly affect the functions of cells involved in inflammatory and immunological phenomena. The Kupffer cell blockade induced by GdCl3 is a generally accepted method for investigation of the physiological and pathophysiological roles of Kupffer cells. Potential beneficial effects of macrophage blockade have been demonstrated in different shock states, liver injury and obstructive jaundice.
- Published
- 2014