1. Simkania negevensis and acute cellular rejection in lung transplant recipients.
- Author
-
Jamal AJ, Resende MR, Prochnow T, McGilvray I, Pilewski JM, Crespo MM, Singer LG, McCurry KR, Kolls JK, Keshavjee S, Liles WC, and Husain S
- Subjects
- Adult, Bronchoalveolar Lavage Fluid microbiology, Canada epidemiology, Chlamydiales genetics, DNA, Bacterial genetics, Female, Follow-Up Studies, Graft Survival, Gram-Negative Bacterial Infections microbiology, Humans, Immunosuppressive Agents therapeutic use, Lung Diseases microbiology, Male, Middle Aged, Prevalence, Prognosis, Prospective Studies, Real-Time Polymerase Chain Reaction, Risk Factors, Transplant Recipients, United States epidemiology, Chlamydiales isolation & purification, Graft Rejection epidemiology, Graft Rejection microbiology, Gram-Negative Bacterial Infections complications, Lung Diseases surgery, Lung Transplantation adverse effects, Postoperative Complications
- Abstract
Simkania negevensis infection has been hypothesized to play a role in lung transplant rejection. The incidence of S. negevensis infection and its association with acute cellular rejection (ACR) were determined in a prospective cohort study of 78 lung transplant recipients (LTRs) in Toronto, Canada, and Pittsburgh, USA, from July 2007 to January 2010. Simkania negevensis testing was detected by quantitative polymerase chain reaction (PCR) on bronchoalveolar lavage fluid. The relationship between S. negevensis and ACR was examined using Cox proportional hazards models and generalized linear and latent mixed models. Cumulative incidence estimates for time-to-ACR in S. negevensis PCR-positive vs. PCR-negative LTRs were 52.7% vs. 31.1% at six months and 68.9% vs. 44.6% at one yr, respectively. Although not statistically significant, there was a trend toward a higher risk of ACR among S. negevensis PCR-positive vs. PCR-negative LTRs in all statistical models., (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2015
- Full Text
- View/download PDF