1. STX6 rs1411478 is not associated with increased risk of Parkinson's disease.
- Author
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Trinh J, Vilariño-Güell C, Donald A, Shah B, Yu I, Szu-Tu C, Aasly JO, Wu RM, Hentati F, Rajput AH, Rajput A, and Farrer MJ
- Subjects
- Adult, Aged, Aged, 80 and over, Canada ethnology, Case-Control Studies, Female, Genetic Predisposition to Disease ethnology, Humans, Male, Middle Aged, Norway ethnology, Parkinson Disease ethnology, Risk Factors, Taiwan ethnology, Tunisia ethnology, Genetic Association Studies methods, Genetic Predisposition to Disease genetics, Parkinson Disease diagnosis, Parkinson Disease genetics, Qa-SNARE Proteins genetics
- Abstract
A variant in Syntaxin 6 (a soluble N-ethylmaleimide-sensitive factor attachment protein receptor STX6) (rs1411478) has been shown to be associated with progressive supranuclear palsy (PSP). Although Parkinson's disease (PD) and PSP are distinct neurodegenerative diseases, they share some clinical and genetic features. In this study, we evaluated STX6 genetic variability in PD susceptibility in ethnically matched case-control series from Canada, Norway, Taiwan and Tunisia and we evaluated the presence of pathogenic mutations within families. No pathogenic mutations were found in STX6. Similarly, statistical analysis of rs1411478 failed to identify differences in genotype or allelic frequencies between cases and controls. Our results do not support a role for STX6 in PD., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2013
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