1. Randomized, double-blind, placebo-controlled, clinic-initiated, Canadian multicenter trial of topical edoxudine 3.0% cream in the treatment of recurrent genital herpes. Canadian Cooperative Study Group.
- Author
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Sacks SL, Tyrrell LD, Lawee D, Schlech W 3rd, Gill MJ, Aoki FY, Martel AY, and Singer J
- Subjects
- Administration, Topical, Adolescent, Adult, Antiviral Agents administration & dosage, Antiviral Agents adverse effects, Canada, Deoxyuridine administration & dosage, Deoxyuridine adverse effects, Deoxyuridine therapeutic use, Double-Blind Method, Female, Herpes Genitalis pathology, Humans, Linear Models, Male, Middle Aged, Recurrence, Antiviral Agents therapeutic use, Deoxyuridine analogs & derivatives, Herpes Genitalis drug therapy
- Abstract
Treatment for recurrent genital herpes using edoxudine 3% cream for 5 days was evaluated in 200 patients in a randomized, multicenter, double-blind, placebo-controlled, clinic-initiated trial. Lesion tenderness was predictive of and more sensitive and longer-lasting than the symptom of pain. Among patients receiving placebo, times to crusting (P = .043), cessation of investigator-observed signs (P = .005), lesion-associated signs (P = .02), and groin signs (P = .05) were longer in women. Edoxudine reduced viral shedding in men (mean 2.7 vs. 3.4 days, P = .009) and women (2.0 days vs. 3.5 days, P = .0001). Loss of investigator-observed signs (4.4 vs. 6.2 days, P = .002), investigator-observed lesion tenderness (P = .01), lesion signs (P = .02), groin adenopathy (P = .01), and tenderness (P = .01) occurred earlier in women taking edoxudine. Edoxudine was well-tolerated and reduced several signs of herpes in women. Its clinical role in recurrent genital herpes remains to be fully determined.
- Published
- 1991
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