1. Bioactive metabolites from a marine-derived strain of the fungus Emericella variecolor.
- Author
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Malmstrøm J, Christophersen C, Barrero AF, Oltra JE, Justicia J, and Rosales A
- Subjects
- Animals, Antibiotics, Antineoplastic chemistry, Antibiotics, Antineoplastic pharmacology, Antifungal Agents chemistry, Antifungal Agents pharmacology, Benzyl Alcohols chemistry, Benzyl Alcohols pharmacology, Breast Neoplasms, Caribbean Region, Central Nervous System Neoplasms, Colonic Neoplasms, Cyclopentanes, Drug Screening Assays, Antitumor, Ergosterol, Female, Fungi drug effects, Furans chemistry, Furans pharmacology, Gram-Negative Bacteria drug effects, Gram-Positive Bacteria drug effects, Humans, Kidney Neoplasms, Leukemia P388, Lung Neoplasms, Male, Mice, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Porifera, Prostatic Neoplasms, Spectrophotometry, Ultraviolet, Tumor Cells, Cultured drug effects, Xanthenes chemistry, Xanthenes pharmacology, Antibiotics, Antineoplastic isolation & purification, Antifungal Agents isolation & purification, Benzyl Alcohols isolation & purification, Fungi chemistry, Furans isolation & purification, Xanthenes isolation & purification, Xanthones
- Abstract
From a marine-derived strain of the fungus Emericella variecolor, varitriol (1), varioxirane (2), dihydroterrein (3), and varixanthone (4), besides the known mold metabolites ergosterol, terrein, shamixanthone, and tajixanthone hydrate, were identified. The chemical structures of 1-4 were established by means of spectroscopic techniques and some chemical transformations. In the NCI's 60-cell panel, varitriol (1) displayed increased potency toward selected renal, CNS, and breast cancer cell lines. Varixanthone (4) showed antimicrobial activity.
- Published
- 2002
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