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Researchers at San Francisco State University conducted a study on Rickettsia rickettsii, a tick-borne pathogen causing Pacific Coast tick fever in California. They used molecular and niche modeling approaches to identify potential amplifying hosts for the pathogen, detecting R. rickettsii californica DNA in three mammal species. The research, supported by various organizations, concluded that combining molecular and niche modeling can help identify species involved in emerging tick-borne diseases. This peer-reviewed study provides valuable insights into the transmission cycle and geographic distribution of R. rickettsii californica. [Extracted from the article]

A study conducted by Tulane University in Medellin, Colombia, evaluated the prevalence and distribution of Wolbachia-infected Aedes aegypti mosquitoes two years after large-scale releases. The research found a low prevalence of Wolbachia infection in the mosquitoes, with varying rates across different areas of Medellin. The study suggests a decline in the prevalence of Wolbachia-infected mosquitoes following the completion of their release, indicating the need for further research in this area. [Extracted from the article]

A recent study conducted at Pennsylvania State University explored the effects of transient Wolbachia infections on alphaviruses in Aedes aegypti mosquitoes. The research found variable effects of Wolbachia on viral infections, with some strains enhancing and others suppressing viral replication. These findings highlight the importance of further research into how Wolbachia impacts the virome of wild mosquitoes and the human pathogens they transmit. For more information, readers can refer to the study published in PLOS Neglected Tropical Diseases. [Extracted from the article]

Researchers at Virginia Commonwealth University have found that Orientia tsutsugamushi, the bacterium responsible for scrub typhus, relies on host cell-derived nutrients for survival and pathogenesis. The study showed that the bacterium does not affect overall flux through host central carbon metabolism but reduces host cell mitochondrial activity and ATP levels. The findings suggest that O. tsutsugamushi is adept at scavenging from host metabolism, leading to alterations in host central carbon metabolism that are critical for pathogen fitness. The research was funded by the American Heart Association and the NIH, and the study has been peer-reviewed. [Extracted from the article]

A recent study conducted by Pennsylvania State University (Penn State) has found that the genetics of the mosquito host can significantly affect the ability of Wolbachia bacteria to block pathogen transmission. The researchers used CRISPR-Cas9 mutagenesis to examine the effects of knocking out the alpha Man2 gene in Aedes aegypti mosquitoes. They found that the knockout mutation increased Wolbachia titers and had complex interactions with virus infection and replication. These findings have important implications for the development of Wolbachia-based strategies to control vector-borne diseases. [Extracted from the article]

Keywords: Merida; Mexico; North and Central America; Biological Products; Blood Cells; Connective Tissue Cells; Gram-Negative Bacteria; Health and Medicine; Hemic and Immune Systems; Immunization; Immunology; Lymphocytes; Macrophages; Mononuclear Leukocytes; Mononuclear Phagocyte System; Myeloid Cells; Phagocytes; Proteobacteria; Public Health; Rickettsiaceae; Rickettsieae; Vaccination; Vaccines EN Merida Mexico North and Central America Biological Products Blood Cells Connective Tissue Cells Gram-Negative Bacteria Health and Medicine Hemic and Immune Systems Immunization Immunology Lymphocytes Macrophages Mononuclear Leukocytes Mononuclear Phagocyte System Myeloid Cells Phagocytes Proteobacteria Public Health Rickettsiaceae Rickettsieae Vaccination Vaccines 2023 MAR 15 (NewsRx) -- By a News Reporter-Staff News Editor at Vaccine Weekly -- Current study results on Gram-Negative Bacteria - Rickettsia have been published. IFN-gamma-producing TCD4+ and TCD8+ lymphocyte subpopulations were identified by flow cytometry, as was the percentage of macrophages expressing CD40+, CD80+, HLA-I and HLA-II. [Extracted from the article]