Search

Your search keyword '"heterodimers"' showing total 2 results
Start Over Descriptor "heterodimers" Region central america
2 results on '"heterodimers"'

1. Research Data from Cleveland Clinic Update Understanding of Guanylate Cyclase [Expression of Soluble Guanylate Cyclase (Sgc) and Its Ability To Form a Functional Heterodimer Are Crucial for Reviving the No-sgc Signaling In Pah].

Subjects
GUANYLATE cyclase, SIGNAL peptides, PULMONARY arterial hypertension, HETERODIMERS, HEAT shock proteins
Abstract

Researchers at the Cleveland Clinic investigated the dysfunctional NO-sGC signaling pathway in pulmonary arterial hypertension (PAH) by studying pulmonary arterial smooth muscle cells (PASMCs) from PAH patients. They found low expression of sGC and a poor sGC alpha 1(31 heterodimer, which correlated with low expression of its facilitator chaperon, hsp90. The study suggests that future therapies for PAH could potentially use low doses of NO along with sGC stimulators as a treatment option. [Extracted from the article]

Published
2024

Catalog

Books, media, physical & digital resources
See catalog results