A new report from Mayo Clinic in Rochester, Minnesota discusses a distinctive neoplasm of the skin and subcutis that shares the Ewing sarcoma-associated EWSR1::FLI1 fusion but differs from Ewing sarcoma in other ways. The tumors occurred in 4 men and 1 woman, with a median age of 25 years. They were multinodular and circumscribed, consisting of nests of bland, round cells admixed with hyalinized collagenous bands containing spindled cells. Despite similar gene fusions, these tumors differ substantially from Ewing sarcoma in terms of morphology, immunohistochemistry, epigenetics, and clinical features. The researchers emphasize the need to distinguish these superficial neurocristic EWSR1::FLI1 fusion tumors from true cutaneous Ewing sarcomas. [Extracted from the article]