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The Palaeo-Tethyan tectonic evolution of central Tibet remains a topic of controversy. Two Permian to Late Triassic arc-like volcanic suites have been identified in the eastern Qiangtang (EQ) block of north-central Tibet. Three competing models have been proposed to explain the formation of these volcanic suites, with two models involving a single stage of long-lived subduction but with opposing subduction polarities, while the other model involves a two-stage subduction process. Here, we present new whole-rock geochemistry, including Sr–Nd isotope data, for late Permian felsic volcanics of the Zaduo area. These volcanics are mainly low to middle K calc-alkaline felsic tuffs and rhyolites with SiO2concentrations up to 73 wt.%. In primitive mantle-normalized diagrams, the volcanics are typified by large ion lithophile element enrichment and high-field-strength element (e.g. Nb, Ta, P, and Ti) depletion, with slightly negative Eu anomalies. They have initial Sr ratios (87Sr/86Sr)iof 0.70319–0.70547, and ϵNd(t) values of +3.4 to +3.5, suggesting derivation by the partial melting of a depleted mantle wedge, followed by assimilation of crustal material. The available geochemical data indicate the presence of two distinctive igneous evolution trends within the Permian to Late Triassic volcanics of the EQ block, consistent with a two-stage subduction model. Permian to Early Triassic arc-like volcanics are formed during northward (present-day orientation) subduction, whereas the Late Triassic volcanics are related to southward (present-day orientation) subduction of mafic crust of the Garze–Litang Ocean. [ABSTRACT FROM PUBLISHER]