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The work zone on the urban road network will affect the surrounding road traffic. To represent the influence area of the work zone, the concept of a subnetwork is proposed in this paper. Delineating a suitable subnetwork quantitatively is a challenging problem. To address this issue, the node synthesized indexes (NSI) are deployed as a variability measure that captures both the change of link flow and origin-destination (OD) demand. The inertia-based stochastic user equilibrium with the elastic demand (ISUEED) model is proposed to accurately provide the data of link flow and OD demand for the network with the work zone. Correspondingly, the data of the network without a work zone can be obtained by the stochastic user equilibrium (SUE) model. According to the value of NSI, the initial range of the subnetwork is determined. Finally, the connectivity and compactness can be guaranteed by the modified L-shell algorithm. To demonstrate the performance of the method, two case studies and sensitivity analyses are conducted based on the Braess network and the local road network in Changchun, China. The proposed method is beneficial to reduce the complexity of the traffic model by substituting the entire network with a subnetwork. [ABSTRACT FROM AUTHOR]