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Head injury is the most common and fatal injury in car-pedestrian accidents. Due to the lack of human test data, real-world accident data is useful for the research on the mechanism and tolerance of head injuries. The objective of the present work is to investigate pedestrian head-brain injuries through real car-pedestrian accidents and evaluate the existed injury criteria. Seven car-to-pedestrian accidents in China were selected from the IVAC (Investigation of Vehicle Accident in Changsha) database. Accident reconstructions using multi-body models were conducted to determine the kinematic parameters associated with the injury and were used to measure head injury criteria. Kinematic parameters were input into a finite element model to run simulations on the head-brain and car interface to determine levels of brain tissue stress, strain, and brain tissue injury criteria. A binary logistic regression model was used to determine the probability of head injury risk associated with AIS3+ injuries (Abbreviated Injury Scale). The results showed that head injury criteria using kinematic parameters can effectively predict injury risk of a pedestrians' head skull. Regarding brain injuries, physical parameters like coup/countercoup pressure are more effective predictors. The results of this study can be used as the background knowledge for pedestrian friendly car design. [ABSTRACT FROM AUTHOR]