1. Full-genome sequences of GII.13[P21] recombinant norovirus strains from an outbreak in Changsha, China.
- Author
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Huang, Zheng, Yao, Dong, Xiao, Shan, Yang, Dong, and Ou, Xinhua
- Subjects
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BLOOD group antigens , *NUCLEOTIDE sequence , *RECOMBINANT viruses , *BINDING sites , *NUCLEOTIDE sequencing , *NOROVIRUSES , *CHLOROPLAST DNA - Abstract
On 31 March 2019, 68 school students suffered from vomiting, diarrhea, and abdominal pain after participating in a group activity at a commercial park. In this outbreak, multiple norovirus genotypes were observed, including GII.2[P16], GII.17[P17], and GII.13[P21]. Further, we determined the full-genome sequences of two strains of GII.13[P21] recombinant noroviruses, which were 7434 nt long. Phylogenetic analysis based on open reading frames (ORFs) 1 and 2 revealed that these recombinants were related to stains of different genotypes from different countries. The full genome nucleotide sequences of the two isolates were 97.0% and 98.0% identical to those of strains from London and Thailand, respectively. Simplot analysis revealed the presence of a break point at nt 5059 in the ORF1 region. The histo-blood group antigen binding sites were conserved in both recombinant viruses. Our findings not only provide valuable genetic information about a recombinant norovirus but also contribute to our general understanding of the evolution, genetic diversity, and distribution of noroviruses. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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