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Adakitic rocks and related Cu-Au mineralization are widespread along eastern Jiangnan Orogen in South China. Previous studies have mainly concentrated on those in the Dexing area in northeastern Jiangxi Province, but information is lacking on the genesis and setting of those in northwestern Zhejiang Province. The Jiande copper deposit is located in the suture zone between the Yangtze and Cathaysia blocks of South China. This paper presents systematic LA-ICP-MS zircon U-Pb dating and element and Sr-Nd-Hf isotopic data of the Jiande granodiorite porphyry. Zircon dating showed that the Jiande granodiorite porphyry was produced during the Middle Jurassic ( ca. 161 Ma). The Jiande granodiorite porphyry is characterized by adakitic geochemical affinities with high Sr/Y and LaN/YbN ratios but low Y and Yb contents. The absence of a negative Eu anomaly, extreme depletion in Y and Yb, relatively low MgO contents, and relatively high 207Pb/204Pb ratios, indicated that the Jiande granodiorite porphyry was likely derived from partial melting of the thickened lower continental crust. In addition, the Jiande granodiorite porphyry shows arc magma geochemical features (e.g., Nb, Ta and Ti depletion), with bulk Earth-like εNd (t) values (−2.89 to −1.92), εHf (t) values (−0.6 to +2.8), and initial 87Sr/86Sr (0.7078 to 0.7105). However, a non-arc setting in the Middle Jurassic is indicated by the absence of arc rocks and the presence of rifting-related igneous rock associations in the interior of South China. Combined with the regional Neoproterozoic Jiangnan Orogeny, it indicates that these arc magma geochemical features are possibly inherited from the Neoproterozoic juvenile continental crust formed by the ancient oceanic crust subduction along the Jiangnan Orogen. The geodynamic environment that is responsible for the development of the Middle Jurassic Jiande granodiorite porphyry is likely a localized intra-continental extensional environment along the NE-trending Jiangshan-Shaoxing Deep Fault as a tectonic response to far-field stress at the margins of the rigid South China Plate during the early stage of the paleo-Pacific plate subduction. In terms of Cu mineralization, we suggest that the metal Cu was released from the subducted oceanic slab and reserved in the juvenile crust during Neoproterozoic subduction along the eastern Jiangnan Orogen region. Partial melting of the Cu rich Neoproterozoic juvenile crust during the Middle Jurassic time in the Jiande area caused the formation of adakitic rocks and the Cu deposit. [ABSTRACT FROM AUTHOR]