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Copyright of Architectural Journal / Jian Zhu Xue Bao is the property of Architectural Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agricultural Science & Technology (1008-0864) is the property of Journal of Agricultural Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Brewing is the property of China Brewing Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Shanghai Physical Education Institute / Shanghai Tiyu Xueyuan Xuebao is the property of Shanghai Physical Education Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Agricultural Science & Technology (1008-0864) is the property of Journal of Agricultural Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: The porous scaffold fabricated with collagen and heparin sulfate can effectively immobilize neurotrophic factor and greatly improve neurological and locomotor function recovery. OBJECTIVE: To investigate the effect of collagen/heparan sulfate scaffold loaded with brain-derived neurotrophic factor in the treatment of traumatic brain injury(TBI). METHODS: Collagen scaffolds, collagen/heparan sulfate scaffolds and collagen/heparan sulfate scaffolds loaded with brain-derived neurotrophic factor were prepared. The porosity, water absorption, compression modulus and compression stress of collagen scaffolds and collagen/heparan sulfate scaffolds were measured. The in vitro sustained-release performance of collagen/heparan sulfate scaffolds loaded with brain-derived neurotrophic factor was measured. The cytotoxicity and cytocompatibility of collagen/heparin sulfate scaffolds and collagen/heparin sulfate scaffolds loaded with brain-derived neurotrophic factor were detected. Forty-eight Sprague-Dawley rats were randomly assigned to undergo corresponding interventions: opening bone window followed by suture(control group), induction of craniocerebral trauma(model group), induction of craniocerebral trauma + implantation of collagen/heparin sulfate scaffolds(scaffold group), and induction of craniocerebral trauma + implantation of collagen/heparin sulfate scaffolds loaded with brain-derived neurotrophic factor(brain-derived neurotrophic factor group). After surgery, modified neurological severity scoring and Morris water maze test were performed to evaluate the recovery of neurological and locomotor function. Rat cerebral morphology was performed. This study was approved by the Animal Ethics Committee of Characteristic Medical Center of Chinese People’s Armed Police Force, China. RESULTS AND CONCLUSION: (1) The porosity, compression modulus and compression stress of the collagen/heparin sulfate scaffold were significantly higher than those of the collagen scaffold(P < 0.05), and the water absorption rate of the collagen/heparin sulfate scaffold was lower than that of the collagen scaffold(P < 0.05). (2) Collagen/heparin sulfate scaffolds had no cytotoxicity, and collagen/heparin sulfate scaffolds loaded with brain-derived neurotrophic factor were more conducive to the proliferation of cerebral microvascular endothelial cells; cerebral microvascular endothelial cells grew well and distributed evenly in the micropores of the collagen/heparin sulfate scaffolds loaded with brain-derived neurotrophic factor. (3) There were a large number of newly formed nerve cells and nerve fibers in the lesions in the scaffold and brain-derived neurotrophic factor groups. The number of nerve cells and the density of nerve fibers in the scaffold group were higher compared with the brain-derived neurotrophic factor group. (4) In the brain-derived neurotrophic factor group, escape latency was shorter(P < 0.01, P < 0.05), quadrant stay time and the number of crossing the platform were higher(P < 0.01, P < 0.05) compared with the scaffold and model groups. (5) The modified neurological severity score in the brain-derived neurotrophic factor group was significantly lower than that in the scaffold and model groups, respectively at postoperative 3-7 weeks(P < 0.05, P < 0.01). (6) These results suggest that collagen/heparin sulfate scaffolds loaded with brain-derived neurotrophic factor can promote neurological and locomotor function recovery in rats after traumatic brain injury. [ABSTRACT FROM AUTHOR]

Copyright of Tourism Tribune / Lvyou Xuekan is the property of Tourism Institute of Beijing Union University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Rock & Mineral Analysis is the property of Editorial Board of Rock & Mineral Analysis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Oil Drilling & Production Technology / Shiyou Zuancai Gongyi is the property of Shiyou Zuancai Gongyi Bianjibu and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)