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An accurate and efficient Large-for-Gestational-Age (LGA) classification system is developed to classify a fetus as LGA or non-LGA, which has the potential to assist paediatricians and experts in establishing a state-of-the-art LGA prognosis process. The performance of the proposed scheme is validated by using LGA dataset collected from the National Pre-Pregnancy and Examination Program of China (2010–2013). A master feature vector is created to establish primarily data pre-processing, which includes a features' discretization process and the entertainment of missing values and data imbalance issues. A principal feature vector is formed using GridSearch-based Recursive Feature Elimination with Cross-Validation (RFECV) + Information Gain (IG) feature selection scheme followed by stacking to select, rank, and extract significant features from the LGA dataset. Based on the proposed scheme, different features subset are identified and provided to four different machine learning (ML) classifiers. The proposed GridSearch-based RFECV+IG feature selection scheme with stacking using SVM (linear kernel) best suits the said classification process followed by SVM (RBF kernel) and LR classifiers. The Decision Tree (DT) classifier is not suggested because of its low performance. The highest prediction precision, recall, accuracy, Area Under the Curve (AUC), specificity, and F1 scores of 0.92, 0.87, 0.92, 0.95, 0.95, and 0.89 are achieved with SVM (linear kernel) classifier using top ten principal features subset, which is, in fact higher than the baselines methods. Moreover, almost every classification scheme best performed with ten principal feature subsets. Therefore, the proposed scheme has the potential to establish an efficient LGA prognosis process using gestational parameters, which can assist paediatricians and experts to improve the health of a newborn using computer aided-diagnostic system. [ABSTRACT FROM AUTHOR]