1. An Atlas of Anionic Antimicrobial Peptides from Amphibians.
- Author
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Dennison SR, Harris F, Mura M, and Phoenix DA
- Subjects
- Africa, Amphibian Proteins therapeutic use, Amyloid metabolism, Animals, Anions chemistry, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents therapeutic use, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Antineoplastic Agents therapeutic use, Antiviral Agents chemistry, Antiviral Agents pharmacology, China, Humans, Peptides therapeutic use, Protein Binding, Signal Transduction, South America, Amphibian Proteins chemistry, Amphibian Proteins pharmacology, Amphibians metabolism, Peptides chemistry, Peptides pharmacology
- Abstract
Anionic antimicrobial peptides (AAMPs) with net charges ranging from -1 to -8 have been identified in frogs, toads, newts and salamanders across Africa, South America and China. Most of these peptides show antibacterial activity and a number of them are multifunctional, variously showing antifungal activity, anticancer action, neuropeptide function and the ability to potentiate conventional antibiotics. Antimicrobial mechanisms proposed for these AAMPs, include toroidal pore formation and the Shai-Huang-Matsazuki model of membrane interaction along with pH dependent amyloidogenesis and membranolysis via tilted peptide formation. The potential for therapeutic and biotechnical application of these AAMPs has been demonstrated, including the development of amyloid-based nanomaterials and antiviral agents. It is concluded that amphibian AAMPs represent an untapped potential source of biologically active agents and merit far greater research interest., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
- Published
- 2018
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