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The present research aims to address the highly topical issue of heavy metal water pollution from an integrated European perspective, i.e., to quantify through modelling a general model of water pollution reduction in the EU. The objectives of the study are mainly aimed at identifying effective solutions to reduce heavy metal water pollution and providing supranational decision-makers with public policy directions in the field. The research methods consist of the foundation of working hypotheses based on the study of the literature, the consolidation of official statistical databases in the field, econometric modelling and the conceptualisation of a general model and its testing and validation by statistical methods. The results of the analysis consist of the following marginal contributions: the identification of a general model for combating heavy metal pollution; the calculation of the degree of contribution of regional policies to the general model; and the identification of effective solutions to improve the combating of heavy metal water pollution in Europe. The main conclusion of the analysis shows that significant progress has been achieved at the EU level in the field of combating heavy metal water pollution. However, the level of disparity and poor policy coordination are real vulnerabilities for the EU.