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Researchers from Zhejiang University in China have developed a biomaterial scaffold that mimics the structure and function of lymph nodes to enhance the effectiveness of CAR-T cell therapy for solid tumors. The scaffold, made from poly(lactic-co-glycolic acid) (PLGA), can accommodate a large number of CAR-T cells and is adorned with signaling molecules for T cell activation. In vitro and in vivo experiments showed that the scaffold significantly increased CAR-T cell proliferation and retained their killing activity within solid tumors. This new strategy could potentially improve CAR-T therapy for solid tumor treatment. [Extracted from the article]

A report from Guangdong Pharmaceutical University in China discusses the potential use of mesenchymal stem cells (MSCs) as a therapeutic strategy for Alport syndrome (AS), a hereditary renal disease. The researchers have designed a clinical trial to evaluate the safety and efficacy of intravenous infusion of human umbilical cord-derived MSCs in children with early-stage AS. The trial will involve 12 patients who will receive MSC infusions and undergo follow-up assessments. The primary endpoints of the trial are the occurrence of adverse events and the level of albuminuria, with secondary endpoints including haematuria and glomerular filtration measurements. The protocol for the trial has been approved by the institutional review board, and informed consent will be obtained from participants. The trial is registered under the number ISRCTN62094626. A lay summary of the study will be made available to participants and the public on the Chinese Organization for Rare Disorders website. [Extracted from the article]

A study conducted at Guangdong University of Technology in Guangzhou, China, has reported the development of a responsive hydrogel with robust mechanical properties for use in tissue engineering, drug release, actuators, and sensors. The hydrogel was constructed using a simple method that incorporated multiple reversible interactions, resulting in exceptional mechanical strength, flexibility, and rapid response to pH alterations. The hydrogel also demonstrated good ionic conductivity, sensitivity, and stability. This research establishes an effective design strategy for creating tough and multifunctional responsive hydrogels. [Extracted from the article]

LifeSprout, a regenerative medicine company, has entered into an agreement with Boyang Trading to develop and commercialize the Lumina dermal filler in mainland China, Hong Kong, Macau, and Taiwan. Lumina is the first product from LifeSprout's Regenerative Matrix platform, which uses biomimetic materials to mimic native soft tissue. LifeSprout will receive an upfront payment and potential milestone payments and royalties. The company is also seeking licensing opportunities for Lumina in other regions. Lumina has completed a successful clinical trial and is targeting regulatory approvals in the United States and European Union in 2025. Boyang Trading believes that regenerative products like Lumina represent the future of the medical aesthetics industry. [Extracted from the article]

A recent study conducted by researchers at Dalian University of Technology in China compared the biomechanical effects of different artificial cervical discs used in intervertebral disc replacement surgery and hybrid surgery (HS). The study focused on the Mobi-C and Prestige LP artificial disc prostheses and their impact on the operative and adjacent segments during two-level hybrid surgery. The researchers used a three-dimensional finite element model to simulate the surgical procedures and analyzed the range of motion, intervertebral pressure, and facet joint force. The results showed that while Mobi-C improved the range of motion and intervertebral pressure more effectively, it may lead to higher facet joint pressure compared to Prestige LP. This research provides valuable insights into the biomechanical behavior of artificial cervical discs in hybrid surgery. [Extracted from the article]

A new report discusses research findings on regenerative medicine, specifically tissue engineering as a potential solution to the shortage of donor organs for transplantation. Researchers at Renmin Hospital of Wuhan University in China have developed an integrated device using exosome-hyaluronic acid-based hydrogel to examine the characteristics of biomaterials and assess their osteogenic and angiogenic properties. The study aims to create stable variables for clinical purposes and comprehensively evaluate the ex vivo and in vivo metrics of osteogenesis and vascularity. This research provides valuable insights into the development of regenerative medicine and biomaterials for tissue regeneration. [Extracted from the article]

A recent report from Lanzhou University in China discusses the potential of using human induced pluripotent stem cells (hiPSC) for tissue regeneration in the temporomandibular joint (TMJ) disc. The researchers investigated the feasibility of differentiating hiPSC into TMJ disc cells in vitro using direct induction and Transwell co-culture methods. They found that hiPSC were able to differentiate into TMJ disc cells using both methods, with the highest degree of differentiation observed after 14 days of direct induction. The study provides valuable insights into the differentiation of hiPSC into TMJ disc cells and offers new ideas for seed cell selection in TMJ disc tissue engineering. [Extracted from the article]

A recent report from Chongqing University in China discusses the advancements and challenges in the field of regenerative medicine, specifically focusing on brain organoids. Brain organoids are being used as platforms to study human neural development and diseases. The report analyzes global trends in brain organoid research over the past decade, including publications, countries, organizations, journals, authors, and keywords. It also explores the various applications of brain organoids in neuroscience, such as neural disorders, drug discovery, and toxicity assessment. The report concludes by highlighting the current challenges in brain organoid research and proposing future strategies to advance neuroscience. [Extracted from the article]

Researchers at Hunan University of Arts and Science in China have developed a new technique for knee joint repair using a hybrid hyaluronic acid-alginate filler reinforced with hydroxyapatite-titanium nanoparticles. The study found that the composite scaffolds exhibited suitable properties for bone applications and showed potential for joint bonding. The scaffolds promoted the proliferation and growth of osteoblast cells and improved cell viability. Further research is needed to confirm the efficacy of these porous scaffolds as bone fillers for sports-related injuries. [Extracted from the article]

A recent study conducted at the Affiliated Hospital of Southwest Medical University in Luzhou, China, explores the potential of combining chimeric antigen receptor (CAR) modified natural killer (NK) cell therapy with radiotherapy to treat solid tumors. While CAR-NK cell therapy has shown promise in treating hematologic malignancies, its efficacy against solid tumors has been limited due to challenges posed by the solid tumor microenvironment. The researchers hypothesize that integrating CAR-NK cell therapy with radiotherapy could enhance the ability to treat solid tumors by modulating the tumor microenvironment and facilitating immune cell infiltration. The study suggests that this synergistic treatment strategy could lead to improved prognoses for patients with solid tumors. [Extracted from the article]

A study conducted by researchers at Nantong University in China explores the field of tissue engineering and its potential applications in peripheral nerve regeneration. Peripheral nerve injury (PNI) is a significant global issue caused by trauma, accidents, war, and surgical complications. The study focuses on the development of artificial nerve scaffolds that can guide Schwann cell myelination and axonal growth, which are crucial for nerve regeneration. The researchers discuss various evaluation methods used to assess the effectiveness of these scaffolds in promoting Schwann cell functions and axonal growth in regenerated nerves. [Extracted from the article]

A new study on regenerative medicine has been published by researchers from the Affiliated Hospital of Qingdao University in China. The study focuses on the regulatory effect of growth differentiation factor 11 (GDF11) on different cells. GDF11 has been found to have therapeutic effects on various diseases, such as anti-myocardial aging and anti-tumor. The researchers aim to better understand the role and potential of GDF11 through extensive research and discussion, in order to develop more effective treatment strategies in the future. [Extracted from the article]

A recent report from the Guangzhou Women and Children's Medical Center in China discusses the use of cell transplantation therapy for traumatic spinal cord injuries (TSCI). The researchers conducted a bibliometric analysis of 284 papers published between 2013 and 2023, finding that the number of articles published has remained relatively stable while the number of citations has increased. Mainland China and the United States are leading countries in this field, with the University of Toronto being a prolific institution. The study identifies current research hotspots, such as marrow stromal cells and glial progenitor, and suggests potential future research directions, including nerve regeneration and the safety of transplantation. The findings contribute to the understanding of cell transplantation for TSCI and may guide further scientific research in this area. [Extracted from the article]

A report from the University of Electronic Science and Technology of China discusses the use of organoid bioprinting in regenerative medicine. Organoids are three-dimensional cell structures that can mimic real organs in structure and function. Bioprinting technology has expanded the applications of organoids in drug screening and regenerative medicine. The review covers bioinks and bioprinting methods for stem cell and organoid bioprinting, vascularization strategies for bioprinting organoids, and applications in biomedicine. The development of microfluidic technology and four-dimensional bioprinting technology may further enhance the creation of bioprinted organoids in the future. [Extracted from the article]

A research study conducted at Shenzhen People's Hospital in China has provided new insights into hematopoietic redefinition and new paradigms in the hematopoietic hierarchy roadmap. The study aimed to redefine the spectrum of adult hematopoietic progenitors and understand the mechanisms underlying hematopoiesis and lineage commitment. Through comprehensive transcriptome analysis, the researchers identified unique markers and transcription factors that accurately defined progenitor lineages. The study also revealed the major fate decision factors in each branch of the hematopoietic hierarchy and reaffirmed the continuous process of the megakaryocytic-erythroid lineage and the stepwise progression of the lymphoid lineage. The findings have implications for regenerative medicine and disease treatment. [Extracted from the article]

A recent study conducted by Zhejiang University School of Medicine in China explored the use of dasatinib and CAR-T cell therapy for newly diagnosed Ph-positive acute lymphoblastic leukemia (ALL) in adults. The researchers found that the combination of dasatinib and CAR-T cell therapy resulted in high rates of complete molecular response, long-term survival, low toxicity, and short treatment cycles. The study included 18 patients who received CD19 CAR-T cell infusions, and 14 of these patients also received subsequent CD22 CAR-T cell infusions. At the end of induction therapy, all patients achieved complete hematologic remission, and 27.8% had a complete molecular response. After CD19 CAR-T cell therapy, the percentage of complete molecular response increased to 72.2%, and further increased to 76.9% after CD22 CAR-T cell therapy. The researchers noted that no grade 3 or higher cytokine release syndrome or immune effector cell-associated neurotoxicity syndrome was observed during CAR-T cell therapies. This treatment approach offers a chemotherapy-free option for newly diagnosed Ph-positive ALL with positive outcomes and minimal side effects. [Extracted from the article]

A recent study conducted at the General Hospital of Ningxia Medical University in China has developed a high-strength ceramic artificial bone loaded with the anti-tuberculosis drug PaMZ. The researchers used 3D printing technology to create the artificial bones and then incorporated the drug onto the surface. The drug-loaded ceramic artificial bone exhibited favorable physical characteristics and demonstrated good biocompatibility and osteogenic properties. This research provides a promising development in the field of artificial bone and tuberculosis treatment. [Extracted from the article]

A recent study conducted at Tianjin First Central Hospital in China investigated the use of BTK inhibitors as a bridging therapy before anti-CD19-CAR T-cell therapy in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The study found that the duration of BTK inhibitor bridging therapy affected the efficacy and side effects of the treatment, particularly hematological toxicity. Patients with higher primary lines or Richter transformation may benefit from prolonging BTK inhibitor bridging therapy. However, no serious adverse effects were observed due to hematological toxicity. Further research is needed to explore these findings. [Extracted from the article]

A recent study conducted at Qilu Hospital of Shandong University in China explored the therapeutic efficacy of CD19 Chimeric Antigen Receptor T (CAR-T) cell therapy in an immune thrombocytopenia (ITP) mouse model. ITP is an autoimmune disease characterized by excessive platelet destruction and impaired production, leading to a high risk of bleeding. The study found that CD19 CAR-T cell therapy effectively suppressed plasma and B cells, resulting in increased platelet counts and decreased levels of anti-platelet antibodies in the treated mice. These findings suggest that CD19 CAR-T cell immunotherapy may have potential therapeutic applications for ITP. [Extracted from the article]

A multicenter study conducted in China analyzed the use of chimeric antigen receptor T (CAR-T) cell therapy in patients with relapsed acute B-cell lymphoblastic leukemia (B-ALL) after allogeneic stem cell transplantation (allo-HSCT). The study found that CAR-T cells were safe and effective in treating these patients, with 76.92% achieving complete remission at day 28 after CAR-T infusion. The study also found that the occurrence of acute graft-versus-host disease (aGVHD) after CAR-T therapy was higher in patients with HLA-haplotype-matched transplantation. Overall, the findings suggest that CAR-T cell therapy is a viable treatment option for B-ALL patients with post-transplant relapse. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital of Nanchang University in China has explored the efficacy and safety of CD19-specific CAR-T cell therapy as a first-line treatment for B-cell lymphoma associated hemophagocytic lymphohistiocytosis (B-LAHS). The study included a cohort of 13 patients who received CAR-T cell therapy following an immunochemotherapeutic regimen. The results showed a 100% overall response rate for both HLH and lymphoma, with 12 patients maintaining sustained remission. The median overall survival was not reached, and the median progression-free survival was 31.5 months. The CAR-T group demonstrated a significantly better prognosis compared to a non-CAR-T group. Adverse events were manageable, with no exacerbation of hemophagocytic syndrome or patient deaths. The study suggests that CD19 CAR-T cell treatment is highly effective and safe as a first-line therapy for B-LAHS. [Extracted from the article]

A recent study conducted by researchers at Nanchang University in China explores the potential of chimeric antigen receptor (CAR) T-cell therapy in treating glioblastoma, the most common primary brain tumor in adults. The study highlights the limitations of current treatment modalities and the promising advancements in immunotherapy for brain tumor patients. CAR T-cell therapy, which redirects cytotoxicity towards specific targets on tumor cells, is discussed as a potential immunotherapy approach for glioblastoma. The study provides valuable insights into the existing research and future prospects for CAR T-cell immunotherapy in treating this type of cancer. [Extracted from the article]

A recent report from Zhejiang University School of Medicine in China discusses the characteristics of central nervous system (CNS) relapse after CD19 CAR-T cell therapy in patients with relapsed/refractory non-Hodgkin lymphoma (NHL). The study analyzed 80 patients who underwent CAR-T cell therapy and found that 8.43% of patients developed isolated CNS relapse after treatment. The study also found that patients with CNS relapse had significantly lower one-year overall survival and progression-free survival rates compared to those without relapse. The researchers suggest the importance of effective prophylaxis against CNS relapse and the need for further investigation to identify patients who will benefit from prophylaxis. [Extracted from the article]

A recent report discusses research conducted by Central South University in China on tissue engineering and bone regeneration. The study focuses on the challenge of recruiting bone marrow mesenchymal stem cells (BMSCs) for in situ bone regeneration. The researchers developed a novel BMSC-aptamer functionalized hydrogel (BMSC-aptgel) and found that it significantly increased BMSC recruitment, migration, osteogenic differentiation, and biocompatibility. In vivo studies showed that the functionalized hydrogels effectively recruited BMSCs at the fracture site, leading to enhanced new bone formation and mineralization. The study suggests that the BMSC-aptgel could be a promising strategy for promoting in situ bone regeneration. [Extracted from the article]

A report from researchers at the Second Affiliated Hospital of Fujian Medical University in China discusses the use of low-intensity pulsed ultrasound (LIPUS) in studying exosomes derived from stem/progenitor cells. Stem cells and progenitor cells have potential applications in regenerative medicine, but there are limitations to therapies based on these cells and their secreted exosomes. LIPUS is an emerging technology that can produce biochemical changes in cells, affecting their behavior and functions. The report aims to provide a deeper understanding of LIPUS and promote further research and development in this field. [Extracted from the article]

A recent study conducted by researchers at Guangzhou Red Cross Hospital in China explores the use of gelatin methacryloyl (GelMA) hydrogels in wound healing. The researchers highlight the potential of GelMA hydrogels in promoting wound healing and tissue remodeling by reducing inflammation, facilitating vascularization, and supporting cell growth. The study reviews the applications of GelMA hydrogels in skin tissue engineering, wound dressing, and transdermal drug delivery. The researchers aim to inspire further exploration of the potential of GelMA hydrogels in wound healing. [Extracted from the article]

A new report discusses research findings on tissue engineering from Nanjing Tech University in China. The researchers developed a rapid synthesis pathway for hydrogels using a modified form of chitosan as a cross-linking agent and acrylic acid as a monomer. The hydrogel exhibited excellent mechanical strength and degradability, as well as antibacterial properties, making it suitable for tissue engineering applications. The study provides insights into the degradation mechanism of the hydrogel at the chemical bond analysis level. [Extracted from the article]

A recent report from Suzhou University of Science and Technology in China discusses the use of self-powered assemblies in tissue engineering. The researchers highlight the importance of bioelectric phenomena in living organisms and how they regulate cellular and tissue behavior. They describe the use of self-powered nanogenerators, such as TENG and PENG, in these assemblies, which offer advantages such as controllable morphology, portability, low cost, and flexibility. The report explores the applications of these assemblies in bone tissue repair, nerve modulation and injury repair, skin wound healing, and antibacterial purposes. The researchers also discuss the challenges and potential solutions for advancing these self-powered assemblies from the laboratory to clinical applications. [Extracted from the article]

Researchers at the Affiliated Drum Tower Hospital of Nanjing University Medical School in China have conducted research on tissue engineering for the treatment of systemic lupus erythematosus (SLE), a complex autoimmune disease that affects multiple organs and tissues. The researchers highlight the need for novel treatments for SLE, as only a few new drugs have been approved for the disease since the 1950s. They discuss the potential of engineering technologies such as tissue engineering, organs-on-chips, and intelligent delivery systems, including engineered nanocarriers and cell-based therapies, in addressing the limited treatment options for SLE. The research aims to provide insights into the application and challenges of engineering technologies in SLE treatment. [Extracted from the article]

Researchers at the Affiliated Drum Tower Hospital of Nanjing University Medical School in China have conducted research on regenerative medicine, specifically focusing on strategies for engineering neural cell alignment and their biomedical applications. The study highlights the importance of cell alignment in tissue regeneration, particularly for neural cells like neurons. The researchers discuss the advancements in biomaterial technologies that have enabled the engineering of neural cell alignment in vitro and summarize their potential applications in biomedical research, particularly in addressing nervous system injuries. The study also analyzes the current challenges in this field and provides insights into future perspectives. [Extracted from the article]

A recent report from Nanjing University in China discusses the use of engineered artificial skin as a promising alternative to traditional treatments for skin damage caused by burns, injuries, or diseases. Traditional treatments such as skin grafting have limitations, including limited donor skin availability and poor aesthetics. Engineered artificial skin aims to mimic or replace the functions of natural human skin and has applications in medical treatments for severe burns, chronic wounds, and other skin injuries or defects. It can promote wound healing, provide temporary coverage, and restore the skin's barrier function. The report provides an overview of current construction strategies for engineered artificial skin, including cell sources, biomaterials, and construction techniques, and highlights the potential of artificial skin to revolutionize skin reconstruction and advance the field of regenerative medicine. [Extracted from the article]

A recent study conducted at the Harbin Institute of Technology in China explored the properties of biomaterial inks used in tissue engineering. The researchers investigated the adjustability of the inks' rheological properties and analyzed the effects of different viscosities on the printing process. They found that biomaterial inks with high viscosity may offer better versatility in the printing process. The study also discussed various printing protocols for improving efficiency and maintaining cell activity. Overall, this research provides valuable insights for the development of biomaterials in cell culture and tissue engineering. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital of Zhengzhou University in China has found that a 3D printed strontium-doped calcium phosphate ceramic scaffold can enhance early angiogenesis and promote bone repair. The researchers discovered that the scaffold can regulate macrophage polarization, leading to increased angiogenesis and improved bone repair. This finding suggests a new strategy for the treatment of clinical bone defects. The study provides valuable insights into the field of bone research and biomedical engineering. [Extracted from the article]

A recent study conducted by researchers at Wuhan University of Technology in China has developed a new bioactive citrate-based polyurethane tissue adhesive that can rapidly and strongly adhere to tissues. This adhesive overcomes the limitations of sutures and other commercial tissue adhesives by providing a non-invasive, liquid-tight, and seamless closure of skin incisions. It also exhibits biocompatibility, biodegradability, and hemostatic properties. The adhesive's degradation product, citrate, promotes angiogenesis and accelerates wound healing. This research provides valuable insights into the development of polyurethane-based tissue adhesives. [Extracted from the article]

A recent study from Capital Medical University in Beijing, China, explores the use of 3D bioprinting and bionic strategies in tissue engineering, specifically in the context of cartilage tissue repair. The researchers highlight the challenges posed by the different types of cartilage tissue and propose that a bionic approach, which imitates nature, combined with 3D bioprinting technology, could lead to improved tissue repair. The study provides an overview of recent advances in mimicking different types of cartilage tissue using 3D bioprinted constructs. The research was supported by the National Natural Science Foundation of China. [Extracted from the article]

A research study conducted at the Affiliated Hospital of Jining Medical University in China explores the use of exosomes derived from mesenchymal stem cells (MSCs) in regenerative medicine for ischemic heart disease. The study highlights the potential of exosomes to promote cardiac function repair by transporting noncoding RNA and protein. The researchers discuss the challenges of low implantation and survival rates of transplanted stem cells and propose engineering approaches to optimize exosomes for enhanced targeting and therapeutic efficacy. This article provides valuable information for individuals interested in bioengineering, cardiology, and regenerative medicine. [Extracted from the article]

Researchers from the Shenzhen Campus of Sun Yat-sen University in China have developed 3D printed alginate/gelatin-based porous hydrogel scaffolds to improve the healing of diabetic wounds. Diabetic wounds are difficult to heal due to impaired vascularization and tissue regeneration. The scaffolds, made from bio-inks containing sodium alginate, oxidized sodium alginate, gelatin, and CaCO3 microspheres, showed excellent structural stability and promoted tissue growth and angiogenesis. This research provides a potential strategy to enhance diabetic wound healing. [Extracted from the article]

A new report from researchers at the First Affiliated Hospital of Kunming Medical University in China examines the existing research on inflammation in diabetic kidney disease (DKD). The study analyzes articles published in the Web of Science Core Collection over the past 30 years and finds that the literature on inflammation research in DKD has experienced substantial growth. The study identifies key authors, journals, countries, and institutions in this field, as well as emerging research trends such as the investigation of gut microbiota, NLRP3 inflammasome, and therapeutic targets. The researchers suggest that future research should focus on exploring the inflammatory response, identifying specific therapeutic targets, studying biomarkers, and investigating gene therapy and tissue engineering. [Extracted from the article]

A report from Chongqing University of Science and Technology in China discusses the potential of kartogenin, a small molecule, as a therapeutic agent for regenerative medicine. The researchers emphasize the importance of sustained release of kartogenin through appropriate formulation and delivery systems to modulate cell behavior and tissue function. The report provides an overview of kartogenin-functionalized biomaterials, their design, structure, functions, and applications in tissue regeneration. The researchers aim to enhance the development of kartogenin delivery materials in biomedical therapeutics and regenerative medicine by providing a comprehensive understanding of common preparation methods. [Extracted from the article]

This article provides information about a clinical trial, NCT06150365, that is currently recruiting participants in China. The trial aims to investigate the safety and efficacy of personalized KSX01-TCRT in patients with advanced solid tumors. The trial is divided into two stages and has primary outcome measures related to subject safety and tumor efficacy. The document also outlines the specific eligibility criteria for patients, including requirements related to tumor-specific TCR sequences, expected survival time, organ function, and renal function. The study is affiliated with the Cancer Institute and Hospital, Chinese Academy of Medical Sciences, and is expected to be completed by December 1, 2028. [Extracted from the article]

A report from Sichuan University in China discusses research on fibrin tissue adhesives for the treatment of complicated posterior urethral stricture. The study evaluated the success rate of a modified transperineal anastomotic urethroplasty (TAU) technique using bulbocavernosus flap interposition and human fibrin sealant. The results showed that patients who underwent the modified TAU had a higher surgery success rate compared to those who underwent traditional end-to-end anastomotic urethroplasty. The researchers concluded that the modified TAU technique is a safe and feasible option for complicated posterior urethral stricture reconstruction. [Extracted from the article]

A study conducted by researchers at Nantong University in China explores the use of a bionic peptide scaffold to promote peripheral nerve regeneration. The researchers found that the scaffold, which envelops regenerative cytokines and extracellular vesicles, promotes the transformation of M2 macrophages and facilitates the proliferation and migration of Schwann cells, neuron growth, and motor function recovery. The study highlights the important role of M2 macrophages in regulating and restoring injured peripheral nerves and suggests that this bionic peptide scaffold could be used to develop pro-regenerative biomaterials. [Extracted from the article]

A recent study conducted by researchers at Jilin University in China explores the role of autologous platelet concentrates in tissue regeneration. The study highlights the importance of blood components in wound healing and tissue regeneration processes. The researchers discuss how autologous platelet concentrates work in conjunction with different types of biomaterials to enhance tissue healing. The study also emphasizes the use of biomaterials to protect and deliver bioactive molecules, improving the effectiveness of autologous platelet concentrates in tissue regeneration. For more information, the full article can be accessed through the provided link. [Extracted from the article]

A recent report from researchers at the Second Hospital of Jilin University in China discusses the importance of vascularization in bone tissue engineering. The study highlights the challenges of restoring the vascular system in damaged bones and explores pre-vascularization techniques to enhance the blood supply in tissue-engineered scaffolds. The researchers emphasize the need for modification of scaffolds to promote internal vascularization and suggest that their findings could inspire future advancements in clinical vascularized bone construction. The full report can be accessed for free through the provided link. [Extracted from the article]

Researchers at Shanghai Sixth People's Hospital in China have developed a new method for tissue regeneration after osteosarcoma resection. The method involves the use of a freestanding polyelectrolyte membrane (PEM) that incorporates copper-doped laponite (CuLAP) and hyaluronic acid (HA). The CuLAP has photothermal conversion capabilities and glutathione-depleted Fenton-like catalytic activity, which aids in tumor ablation and bactericidal effects. The PEM also releases copper ions and silicates, which support angiogenesis and osteogenesis for the regeneration of both soft and hard tissues. This research offers a promising clinical tool for tissue reconstruction after osteosarcoma resection. [Extracted from the article]