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Aroma is an important attribute influencing the perceived quality of Chinese liquors, with each liquor characterized by a unique collection of volatile chemicals. Here, a biomimetic olfactory recognition system combining an optimal panel of 10 mouse odorant receptors with back propagation neural network model was designed to discriminate the aromas of Chinese liquors. Our system shows an excellent predictive capacity with an average accuracy of 96.5% to discriminate liquors of different aroma types, as well as those of different brands and ageing years within the same aroma type. A total of 124 interactions between liquor aroma compounds and odorant receptors were further elucidated to understand odorant coding at the molecular level, including 14 newly deorphaned odorant receptors. Our work represents a proof of concept for combining receptors and machine learning in the discrimination of complex odorant stimuli., (Copyright © 2022 Elsevier Ltd. All rights reserved.)

Rationale: Glucose oxidase (GOx)-based biocatalytic nanoreactors can cut off the energy supply of tumors for starvation therapy and deoxygenation-activated chemotherapy. However, these nanoreactors, including mesoporous silica, calcium phosphate, metal-organic framework, or polymer nanocarriers, cannot completely block the reaction of GOx with glucose in the blood, inducing systemic toxicity from hydrogen peroxide (H 2 O 2 ) and anoxia. The low enzyme loading capacity can reduce systemic toxicity but limits its therapeutic effect. Here, we describe a real 'ON/OFF' intelligent nanoreactor with a core-shell structure (GOx + tirazapamine (TPZ))/ZIF-8@ZIF-8 modified with the red cell membrane (GTZ@Z-RBM) for cargo delivery. Methods: GTZ@Z-RBM nanoparticles (NPs) were prepared by the co-precipitation and epitaxial growth process under mild conditions. The core-shell structure loaded with GOx and TPZ was characterized for hydrate particle size and surface charge. The GTZ@Z-RBM NPs morphology, drug, and GOx loading/releasing abilities, system toxicity, multimodal synergistic therapy, and tumor metastasis suppression were investigated. The in vitro and in vivo outcomes of GTZ@Z-RBM NPs were assessed in 4T1 breast cancer cells. Results: GTZ@Z-RBM NPs could spatially isolate the enzyme from glucose in a physiological environment, reducing systemic toxicity. The fabricated nanoreactor with high enzyme loading capacity and good biocompatibility could deliver GOx and TPZ to the tumors, thereby exhausting glucose, generating H 2 O 2 , and aggravating hypoxic microenvironment for starvation therapy, DNA damage, and deoxygenation-activated chemotherapy. Significantly, the synergistic therapy effectively suppressed the breast cancer metastasis in mice and prolonged life without systemic toxicity. The in vitro and in vivo results provided evidence that our biomimetic nanoreactor had a powerful synergistic cascade effect in treating breast cancer. Conclusion: GTZ@Z-RBM NPs can be used as an 'ON/OFF' intelligent nanoreactor to deliver GOx and TPZ for multimodal synergistic therapy and tumor metastasis suppression., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)

The black soil of Northeast China is sticky and agglomerates easily, which often adheres to the surface of a traditional furrow opener during the furrowing process. In this paper, biomimetic design principles in resistance-reducing, anti-adhesion and resistance-reducing mechanism of biomimetic disc furrow opener were studied. Nine kinds of singular convex hull, nine kinds of singular wedge and nine kinds of mixed convex hull and wedge structural biomimetic disc furrow opener were designed, and the furrowing process with the soil simulated by finite element method (FEM).Three types of biomimetic disc furrow opener with less resistance were manufactured by laser processing for comparative test in soil bin based on the simulation results. The test results showed that the resistance of the biomimetic disc furrow opener was less than that of the ordinary disc. The soil-disc stress, influence of biomimetic structures, moisture content and furrow speeds on resistance were discussed. The resistance-reducing rate of D-BC-3 reached the maximum value 15.36% at the furrow speed of 0.6 m/s and the soil moisture content of 20%. It is believed that the biomimetic design principles can provide the significant inspirations for the future design of disc furrow opener with drag reduction.

Based on computed tomography (CT) data and histological analysis, a biomimetic modeling is established that mimics the interior configuration of natural bone to provide bionic three-dimension (3D) model of the artificial bone, thus obtaining processing files for fabrication. In this study, porosity ratio and process route of the microarchitecture in the modeling are analysed. Furthermore, through the simulation experiment, it shows that the biomimetic modeling can simulate the fidelity of the interior osteo-structure analogous microarchitecture.