1. A genomewide search for quantitative-trait loci underlying asthma.
- Author
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Xu X, Fang Z, Wang B, Chen C, Guang W, Jin Y, Yang J, Lewitzky S, Aelony A, Parker A, Meyer J, Weiss ST, and Xu X
- Subjects
- Adult, Allergens immunology, Animals, Antigens, Dermatophagoides, Asthma blood, Asthma chemically induced, Bronchoconstrictor Agents pharmacology, China, Chromosome Mapping, Chromosomes, Human, Pair 2 genetics, Cockroaches immunology, Eosinophils, Female, Forced Expiratory Volume genetics, Glycoproteins immunology, Humans, Immunoglobulin E blood, Immunoglobulin E immunology, Leukocyte Count, Male, Methacholine Chloride pharmacology, Phenotype, Skin Tests, Vital Capacity genetics, Asthma genetics, Asthma immunology, Chromosomes, Human genetics, Genetic Linkage genetics, Quantitative Trait, Heritable
- Abstract
A genomewide screen for quantitative-trait loci (QTLs) that underlie asthma was performed on 533 Chinese families with asthma, by the unified Haseman-Elston method. Nine asthma-related phenotypes were studied, including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), airway responsiveness as indicated by methacholine (MTCH)-challenge test, serum total immunoglobulin E (TIgE), serum-specific immunoglobulin E, eosinophil count in peripheral blood, and skin-prick tests with three different allergens (cockroach, Dermatophagoides pteronyssinus, and D. farinae). Our study showed significant linkage between airway responsiveness to MTCH and D2S1780 on chromosome 2 (P<.00002) and provided suggestive evidence (P<.002) for six additional possible QTLs: D10S1435 and D22S685, for FEV1; D16S412, for FVC; D19S433, for airway responsiveness to MTCH; D1S518, for TIgE; and D4S1647, for skin reactivity to cockroach. No significant or suggestive evidence of linkage for the other four traits was found.
- Published
- 2001
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