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Clonorchiasis is caused by ingestion of raw freshwater fish containing infective larvae of Clonorchis sinensis. China harbours the largest number of people with C. sinensis infection. During the past three decades, the National Institute of Parasitic Diseases, affiliated to the Chinese Center for Disease Control and Prevention (NIPD) conducted many studies to facilitate the control on clonorchiasis. Three national surveys have shown the updated epidemiology of clonorchiasis in China. Recently, a national surveillance system has also been established, which will enable the production of high-resolution map. The evaluation of the disease burden has enhanced the awareness on clonorchiasis. Diverse diagnosis techniques including rapid screening by questionnaire, serological tests, faecal examination and a molecular method have been developed or evaluated. The NIPD also participated in the early evaluation of praziquantel against clonorchiasis, which enhanced its application in China. Also, the NIPD has verified the efficacy of tribendimidine against clonorchiasis. A new sustainable strategy is also being explored. However, more research is expected to further facilitate control of clonorchiasis in China, as well as international cooperation in fighting human liver fluke infections in Asia. [ABSTRACT FROM AUTHOR]

Soil-transmitted helminthiases (STHs) have been widely transmitted in China and the control of STHs was initiated by NIPD-CTDR since its foundation. Three national surveys on STHs have been carried out in China, and the infection rate has dropped from 53.58% in the first national survey (1988-92) to 4.49% in the third national survey (2014-16) due to strong interventions including mass drug administration, health education and environment improvement. National surveillance of STHs started in 2006 and has been implemented successively until now, which allows to understand the endemic status and trends of STHs prevalence in China. Surveillance has been expanded to 30 provinces of China since 2016. Integrated pilot programmes have been implemented between 2006 and 2009, in which an integrated strategy, with health education and control of infection sources as key components, was adopted. Since 2019, new control pilots have been started, which will be continued for five successive years to further explore appropriate control strategies in the current "new era". With the decline of infection rate of STHs, China is approaching the elimination stage for STHs. In order to achieve this final target, poverty alleviation programmes should be integrated with precise control measures, according to real situations. [ABSTRACT FROM AUTHOR]

Background and purpose Astragalus membranaceus (AM) is the first-choice herb for fatigue treatment in traditional Chinese medicine and the main herb used for stroke treatment in China and Taiwan. The purpose of this study was to evaluate the effect of AM on poststroke fatigue (PSF). Materials and methods This study was designed as a double-blind, randomized, controlled preliminary study. Sixty-four patients with PSF were assigned to treatment group (TG; 31 patients), which received oral administration of AM (2.8 g three times per day) for 28 days, and a control group (CG; 33 patients), which received a placebo. The primary outcome measures were the changes in the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and Brief Fatigue Index (BFI) scores Results A total of 61 patients (29 patients in the TG and 32 patients in the CG) completed the trial. The difference in BFI scores between Visit 2 and Visit 1 was –17.83±17.70 in the TG, which was greater than that in the CG (–8.03±9.95; p =0.01); additionally, the difference in BFI scores between Visit 3 and Visit 1 was –16.48±16.41 in the TG, which was also greater than that in the CG (–9.47±13.39; p =0.05). In the EORTC QLQ-C30, the difference in cognitive functioning scores between Visit 2 and Visit 1 was 14.37±13.89 in the TG, which was greater than that in the CG (3.65±19.74; p =0.02); additionally, the difference in these scores between Visit 3 and Visit 1 was 14.37±16.50 in the TG, which again was greater than that in the CG (6.25±19.74; p =0.04). The difference in social functioning scores between Visit 3 and Visit 1 was 9.77±15.12 in the TG, which was greater than that in the CG (–1.56±20.46; p =0.01). The difference in global quality of life (QOL) scores between Visit 2 and Visit 1 was 14.08±18.78 in the TG, which was also greater than that in the CG (1.56±18.14; p =0.003); moreover, the difference in these scores between Visit 3 and Visit 1 was 10.92±17.55 in the TG, and this was greater than that in the CG (1.82±15.8; p =0.05). Conclusion AM can improve BFI scores; cognitive functioning, social functioning, and global QOL scores in the EORTC QLQ-C30. Our results suggest that physicians should pay close attention to the unmet medical needs of patients with PSF. AM is helpful for treating patients with PSF; however, additional studies with a larger sample and a longer period of investigation are required. [ABSTRACT FROM AUTHOR]

Oil continues to be a major source of world energy, but oil prices and funds have experienced high volatility over the last decade. This study applies the generalized autoregressive conditional heteroskedasticity-mixed-data sampling (GARCH-MIDAS) model on data spanning 1 July 2014 to 30 April 2020 to examine volatility transmission from the equity, bulk shipping, commodity, currency, and crude oil markets to the United States Oil Fund (USO) and BlackRock World Energy Fund A2 (BGF). By dividing the sample into two subsamples, we find a significant volatility transmission from the equity market to the oil ETF and energy fund both before and after the 2018 U.S.–China trade war. The volatility transmission from the bulk shipping, commodity, and crude oil markets turns significant for the oil ETF and energy fund after the 2018 U.S.–China trade war, extending into the COVID-19 pandemic in early 2020. The results suggest that investors can use the equity market to predict the movement of oil and energy funds during both tranquil and turmoil periods. Moreover, investors can use bulk shipping, commodity, and crude oil markets in addition to the equity market to forecast oil and energy funds' volatility during the turmoil periods. This paper benefits investors against the high volatility of the energy funds. [ABSTRACT FROM AUTHOR]

Background: Helminthiases have placed a huge burden of disease on the population in China. However, widespread control activities have led to significant achievements. As health education has been widely disseminated and plays an important role in the control and elimination of these diseases, we collected health education products aimed at controlling and preventing helminthiases in China. We analyzed their characteristics and assessed their quality. Methods: Firstly, health education products aimed at controlling and preventing helminthiases were collected from a diverse range of organizations. Secondly, the expert brainstorming and Delphi methods were applied to establish an evaluation system, which was then used to assess the collected products systematically. Those deemed excellent were awarded. Characteristics – including type, source, targeted disease(s), targeted population, and languages – of the collected products and the awarded products were presented here. Results: In total, 96 health education products on helminthiases were collected from 53 organizations. Most products belonged to either the graphic design (47) or daily-use (24) category. Seventy were collected from Centers for Disease Control and Prevention and 20 from institutes or control stations of parasitic diseases, primarily at the provincial and county levels. Regarding disease targets of the products, 67 focused on a single helminthiasis, 25 on multiple helminthiases, and the remaining four on non-specific diseases. Of the 67 single helminthiasis-focused products, most targeted schistosomiasis (37), followed by echinococcosis (16). The majority of products (79) targeted the general population, while 11 targeted students specifically. Regarding languages, 86 products were only in Chinese, while the other ten were in both Chinese and the minority languages of China. Out of these ten products, one targeted schistosomiasis and the other nine targeted echinococcosis. Thirty-four products were awarded. The characteristics of the awarded products were similar to those of the collected products. Conclusions: A diverse range of health education products have been designed and applied for the prevention and control of helminthiases in China. Many products have good features such as specifying the targeted diseases and populations. However, there are significant gaps in terms of both the quantity and quality of products pertaining to some of the diseases. Experiences from the awarded products could be drawn upon to design more products aimed at a range of different helminthiases. [ABSTRACT FROM AUTHOR]

Seven new species of the family Psychomyiidae Walker, 1852 are described and illustrated from China; they are Psychomyia shuni sp. nov., Ps. mangshanensis sp. nov., Ps. capricornis sp. nov., Lype sagittalis sp. nov., Paduniella fasciaria sp. nov., Pa. sanyaensis sp. nov., and Tinodes aviformis sp. nov. The genus Lype is reported for the first time from mainland China. In addition, four psychomyiids are found to be new to the Chinese caddis fauna: Psychomyia indra Malicky & Chantaramongkol, 1993; Paduniella andamanensis Malicky, 1979; Pa. dendrobia Malicky & Chantaramongkol, 1993; and Tinodes gapbona Johanson & Oláh, 2008. Moreover, Psychomyia polyacantha Li, Qiu & Morse, 2021 is reviewed and synonymized with Psychomyia imamiah Malicky, 2020. [ABSTRACT FROM AUTHOR]

Clonorchiasis is caused by raw-freshwater fish-eating practice and causes high burden in Asia. Transmission mechanism of this behavior hasn't been illuminated, which hinders the adoption of sustainable control activities. A cross-sectional survey was implemented in students from four endemic provinces in China. Data with 23,222 students aged 9–18 and their parents were eligible. Familial clustering of raw-eating practice, impact of parents' practice on children, interaction of spouses' practice was analyzed. Raw-eating practice met β-binomial distribution (χ2 = 0.8, p>0.05). Clustering coefficient increased by students' age (R2 = 0.82, p<0.001) and was higher in those families with boys compared to girls (t = 4.1, p<0.01). The proportion of students with raw-eating practice increased yearly by 8.9% in girls and 10.5% in boys. Compared to those without parents' raw-eating practice, adjusted odds ratio of students' raw-eating practice was 10.5 (95% confidential intervals (95% CI): 9.4–11.7) in those with fathers' practice, 33.6 (95% CI: 26.3–42.9) in those with mothers' practice and 47.1 (95% CI: 42.0–52.8) in those with both parents' practice. There exists interaction between spouses' practice (χ2 = 6713.1, p<0.001) and the impact from husband on his wife was higher than that from wife on her husband. Familial assimilation characterizes the transmission of raw-freshwater fish-eating practice, consisted of vertical intergenerational assimilation from parents to their children and horizontal martial assimilation between spouses. A sustainable strategy against clonorchiasis should interrupt the transmission of raw-freshwater fish-eating practice. Additionally, further studies are expected to explore more information, e.g. the frequency in raw-eating practice and type of raw freshwater fish, infection status of C. sinensis in participants, as well as direct collection of parents' eating information from themselves. Author summary: Clonorchiasis is caused by the ingestion of raw freshwater fish, which contains the infective larvae of Clonorchis sinensis. It is highly endemic in Asia, where about 15 million people are afflicted. To establish sustainable control strategy, the transmission of raw-eating practice needs to be illuminated. In this study, we conducted a survey in school students from four clonorchiasis endemic provinces in China, covering 23,222 students aged 9–18. The characteristics of raw-eating practice, impact of parents' raw-eating practice on children, interaction of spouses' practice was explored. It is demonstrated that raw-eating practice presents familial clustering, which is higher in those families with older children and with boys. Raw-eating practice in children is highly influenced by their parents' raw-eating practice especially when both parents do. Additionally, there exists interaction between spouses' raw-eating practice. The impact of husband's raw-eating practice on his wife is higher than that of wife's raw-eating practice on her husband. Familial assimilation dominates the transmission of raw-freshwater eating-practice, including the assimilation from parents to their children and that between spouses. This finding indicates the adoption of sustainable strategy against clonorchiasis through blocking raw-freshwater fish-eating practice. [ABSTRACT FROM AUTHOR]

The male adult of Molanna truncata Ge, Peng & Sun sp. nov. is described and illustrated based on material collected in Si-chuan, China. It could be diagnosed by the subtriangular superior appendages when viewed dorsally, and by the mesal appendages each having a slender thorn and inferior appendages with a tiny inner process. Based on morphology of genitalia, we provide a dichotomous key to adult males of Molanna from the Oriental region. The DNA barcodes (partial mt COI sequences) of M. truncata sp. nov. are generated and compared with existing sequences of Molanna species from Oriental and Palearctic regions. The mean intraspecific divergence of Molanna was 1.58% with a maximum of 8.50% in M. moesta. The Automatic Barcode Gap Discovery (ABGD) analysis of Molanna inferred 9 OTUs and thresholds of interspecific divergence of 10%. Divergence of M. truncata sp. nov. haplotypes from all other Molanna haplotypes ranged from 10.1% to 18%. We discuss distribution and potential groups of species within the Oriental Molanna species based on morphology [ABSTRACT FROM AUTHOR]

Background: Hookworm disease is endemic in China and is widespread globally. The disease burden to humans is great. Methods: The study described the national surveillance of hookworm implemented in 31 provinces/autonomous regions/municipalities (P/A/Ms) of China in 2019. Each P/A/M determined the number and location of surveillance spots (counties). A unified sampling method was employed, and at least 1000 subjects were investigated in each surveillance spot. The modified Kato-Katz thick smear method was employed for stool examination. Fifty samples positive with hookworm eggs were cultured in each surveillance spot to discriminate species between A. duodenale and N. americanus. Twenty-five soil samples were collected from each surveillance spot and examined for hookworm larva. The 2019 surveillance results were analyzed and compared with that of 2016–2018. Results: A total of 424766 subjects were investigated in 31 P/A/Ms of China in 2019, and the overall hookworm infection rate was 0.85% (3580/424766). The weighted infection and standard infection rates were 0.66% (4288357/648063870) and 0.67% (4343844/648063870), respectively. Sichuan province had the highest standard infection rate (4.75%) in 2019, followed by Chongqing (2.54%) and Hainan (2.44%). The standard infection rates of other P/A/Ms were all below 1%, with no hookworm detected in 15 P/A/Ms. The standard hookworm infection rate in the males and the females were 0.61% (2021216/330728900) and 0.71% (2267141/317334970), respectively, with a significant difference between different genders (χ2 = 17.23, P<0.0001). The highest standard hookworm infection rate (1.97%) was among age ≥ 60 years, followed by 45~59 years (0.77%), 15~44 years (0.37%), and 7~14 years (0.20%). The lowest standard infection rate was among the 0~6 years age group (0.12%). A significant difference was observed among different age groups (χ2 = 2 305.17, P<0.0001). The constitute ratio for N. americanus, A. duodenale, and coinfection was 78.70% (1341/1704), 2.03% (346/1704), and 1.00% (17/1704), respectively. The detection rate of hookworm larva from soil was 3.45% (71/2056). Conclusion: The national surveillance showed that the hookworm infection rate has been decreasing annually from 2016 to 2019, and it is now below 1%. China has made significant progress in controlling hookworm. The national surveillance system is an important way to understand the endemic status and provide important information in this process and thus needs to be continually optimized. Author summary: Hookworm disease is endemic in China. The national surveillance system on important parasitic diseases including hookworm infection has been established in China. Stool samples were collected from participants, and the Kato-Katz method was applied to detect helminth eggs while samples with hookworm eggs were further cultured to differentiate the species of the parasite. Additionally, soil samples were collected and examined for hookworm larva. In 2019, the overall infection rate of hookworm in China was 0.85% (3580/424766). High prevalence was demonstrated in Western and Southern China, including Sichuan (4.75%), Chongqing (2.54%) and Hainan (2.44%). The prevalence was high in the females (0.71%) than in the males (0.61%), while it was high in older population especially those age over 60 years. N. americanus dominated the hookworm species. The prevalence of hookworm in soil was 3.45%. Overally, hookworm infection decreased to a low level in China. However, there still exist high endemic areas. Thus, intervention needs to be applied in the high endemic areas and elder population. [ABSTRACT FROM AUTHOR]

The Central Asian Orogenic Belt (CAOB) is the largest accretionary orogenic belt in the world and its formation involved a complicated process of arc–continent collision. Large‐scale Mesozoic volcanic activity in the Great Xing'an Range (GXAR) in northeastern China, which constitutes part of the eastern CAOB, has received much recent research attention. However, the petrogenesis and formation mechanism of the late Mesozoic igneous rocks remain enigmatic. This paper investigates the geochronology, petrogenesis, and formation mechanism of late Mesozoic magmatic rocks in the Kelihe area of the GXAR based on zircon U–Pb dating, petrology, and geochemistry. Late Mesozoic magmatism in the Kelihe area occurred during the Late Jurassic (165–155 Ma) and Early Cretaceous (130–120 Ma). These igneous rocks generated by this magmatism are characterized by high SiO2 (69.97–75.49 wt%) and low MgO (0.11–0.68 wt%), Cr (10–30 ppm), Co (0.2–2.6 ppm), and Ni (0.5–1.6 ppm) contents. Trace elements show enrichment in Rb, Th, U, Zr, and K, and depletion in Ba, P, Nb, and Ti. These features indicate that the rocks were derived from partial melting of the crust. Furthermore, the rhyolites have high Na2O (5.02–5.44 wt%) and K2O (3.94–4.88 wt%) contents, similar to those of melts formed by the partial melting of basaltic crust. Combining the present results with the findings of previous studies, it is inferred that the Mesozoic igneous rocks formed in a post‐collisional extensional setting related to lithospheric thinning and asthenospheric upwelling after the closure of the Mongol–Okhotsk Ocean. [ABSTRACT FROM AUTHOR]

Abstract: Two late Mesozoic granitoids in the Luanchuan area of the East Qinling orogen are considered; ore-bearing rocks are granite porphyries and granodiorite, with K2O>Na2O, appearing in the form of stocks. The Laojunshan rocks contains dominantly monzonitic granite, with K2O≈Na2O, in the form of a batholith. Both the ore-bearing rocks and the Laojunshan rocks are highly siliceous and shoshonitic, high-K calc-alkaline, similar to some I-type granites. Light rare earth elements (LREEs) are enriched in both rock suites, although the Luanchuan ore-bearing granitoids have higher concentrations, with (La/Yb) N ratios twice that of the barren Laojunshan granite suite. Ore-bearing rocks have, therefore, undergone greater fractionation of heavy rare earth elements. All Laojunshan rocks have negative Eu anomalies, indicating plagioclase fractionation. δEu values are different in both rock suites, the values in the ore-bearing granites, ranging from 0.52 to 1.04, which are much higher than that of Laojunshan batholith, ranging from 0.4 to 0.65. (La/Sm) N values of ore-bearing granites are 5.32–8.28, while that of Laojunshan batholith are 3.75–5.77, confirming the observation that the ore-bearing granites have undergone a higher degree of strong differentiation than that of Lanjunshan batholith. Major and trace element data, and REE data, combined with isotope data from previous work and the close relationships between the tectonic settings of the barren and ore-bearing rocks indicate that both groups of rocks were derived from the lower crust. At ∼157Ma, with the tectonic regime in transition from a syn-collisional to a post-collisional setting, highly fractionated granites ascended from their storage area via faults; at ∼145Ma, ore-bearing plutons, which are triggered by slab melts, formed at the junctions of fault planes trending WNW-ESE and NE-SW. At ∼115Ma, the tectonic regime changed from compression to extension; in this environment, the barren Laojunshan batholith was emplaced, representing the end of the collisional event. [Copyright &y& Elsevier]

Background: Based on two national surveys, the prevalence of soil-transmitted helminthiasis (STH) in China had decreased from 53.58% in 1988–1992 to 19.56% in 2001–2004. To update the epidemiology and characteristics of STH in China, a third national survey was implemented in 2014–2015. Methodology/Principal findings: This survey covered rural areas in 31 provinces in mainland of China. Multiple-stage stratified cluster sampling was employed, which included three levels (provinces, ecozones and economical levels). Stool samples were collected and the Kato-Katz method was applied for helminth eggs detection. Samples with hookworm eggs were selected and hatched to differentiate the species based on larval morphology. Between June 2014 and May 2015, a total of 484,210 participants from 604 counties were enrolled. The weighted prevalence of STH overall was 4.49% (95% confidential interval (CI): 2.45%-6.53%), including 2.62% (95% CI: 0.86%-4.38%) hookworm infections, 1.36% (95% CI: 0.49%-2.23%) ascariasis, and 1.02% (95% CI: 0.15%-1.89%) trichuriasis. The estimated population infected was 29.12 million (95% CI: 15.88 million-42.32 million) for all STH; 16.97 million (95% CI: 5.57 million-28.39 million) for hookworm infections; 8.83 million (95% CI: 3.18 million-14.45 million) for ascariasis; and 6.60 million (95% CI: 0.97 million-12.25 million) for trichuriasis. Overall, the prevalence of ascariasis and trichuriasis was relatively high in children, while hookworm infections were more common in the older population, especially those over 60. STH was highly prevalent in western China, and moderately in central areas, but low in eastern and northern regions. Out of 3,579 hookworm cases with species differentiation, 479 cases (13.38%) were infected with only Ancylostoma spp., 2,808 cases (78.46%) with only Necator americanus, and another 292 cases (8.16%) with both species. Conclusions/Significance: This survey demonstrated the continuous decrease of STH in rural China. However, endemicity still prevails in the western areas of the country. Hookworm, especially N. americanus, is becoming the predominant species. Older farmers in western China should be prioritized for control due to the high prevalence of hookworm. Author summary: Soil-transmitted helminthiasis (STH) had decreased significantly in China based on the two national surveys implemented in 1988–1992 and 2001–2004, respectively. In 2014–2015, an updated national survey on STH was implemented in rural China. This survey covered rural areas of 31 provinces in mainland of China and multiple-stage stratified cluster sampling was employed. Stool samples were collected and examined for helminth eggs. Totally, 484,210 villagers from 604 counties in 31 provinces participated in the survey. The adjusted prevalence of STH was 4.49%, and that of hookworm infections, ascariasis, trichuriasis was 2.62%, 1.36%, 1.02%, respectively. The estimated population with STH was 29.12 million, while that with hookworm infections, ascariasis, trichuriasis was 16.97 million, 8.83 million, 6.60 million, respectively. Children showed a high prevalence in ascariasis and trichuriasis, while the older population had a high prevalence of hookworm infections. STH was still highly prevalent in western parts, moderately in central areas, and low in eastern and northern regions. Further efforts are needed to control STH in China. [ABSTRACT FROM AUTHOR]

Clonorchis sinensis infection is highly prevalent in Asia. Diverse hepatobiliary morbidity has been documented for C. sinensis infection. This study aimed to assess the association between C. sinensis infection and hepatobiliary morbidity, taking into consideration of the control, confounders and infection intensity. A cross-sectional community survey was implemented in Hengxian county, southeastern China. Helminth infections were detected by fecal examination. Physical examination and abdominal ultrasonography were then conducted. After excluding confounding effects from gender, age and alcohol drinking, quantitative association between C. sinensis infection and hepatobiliary morbidity was assessed, and the effect from infection intensity was also evaluated, through adjusted odds ratio (aOR) and 95% confidence intervals (95% CI). 696 villagers older than 10 years were enrolled. The prevalence and infection intensity of C. sinensis were higher in male, elder people and the individuals consuming alcohol. Light C. sinensis infection was associated with the increase of diarrhoea (aOR: 2.2, 95% CI: 1.1–4.5). C. sinensis infection was associated with the increase of fatty liver (aOR: 2.7, 95% CI: 1.4–5.2), and the effect was similar in different infection intensities. Moderate C. sinensis infection was associated with the increase of gallbladder stone (aOR: 3.0, 95% CI: 1.1–8.6), while moderate and heavy infections with the increase of intrahepatic bile duct dilatation (aOR: 2.2, 95% CI: 1.0–4.9 and aOR: 4.3, 95% CI: 1.9–9.9, respectively). C. sinensis infection had an effect on the development of periductal fibrosis (aOR: 3.2, 95% CI: 2.1–4.9), which showed increasing trend by infection intensity. The length and width of gallbladder in those with C. sinensis infection were enlarged, especially in those over 30 years old. C. sinensis infection is significantly associated with hepatobiliary morbidity. The occurrence of some morbidity was strongly related to the infection intensity. Awareness on harm of clonorchiasis should be raised both for policy-makers and villagers to adopt effective interventions. Author summary: Clonorchiasis is caused by ingestion of raw freshwater fish, which carries the larvae of Clonorchis sinensis. In this study, we aimed to assess the damages associated with clonorchiasis. A cross-sectional field survey was carried out in Hengxian county, southeastern China. Stool samples were collected and examined for helminth infections. Then, physical examination and abdominal ultrasonography were conducted. In total, 696 villagers older than 10 years were included. The prevalence and infection intensity of C. sinensis were higher in male, elder people and those drinking alcohol. Excluding the impact from gender, age and alcohol drinking, it was demonstrated that light C. sinensis infection was associated with the increase of diarrhoea, moderate infection with gallbladder stone, and moderate and heavy infections with intrahepatic bile duct dilatation. C. sinensis infection was relevant to the increase of fatty liver, and the effect was similar in different infection intensities. C. sinensis infection was associated with the development of periductal fibrosis and the effect increased by infection intensity. The length and width of gallbladder in individuals with C. sinensis infection were enlarged, especially in those over 30 years old. Thus, our study demonstrates that C. sinensis infection is associated with severe hepatobiliary morbidity, and the effect is strongly related to infection intensity for some morbidity. Concerted efforts should be exerted to tackle the morbidity in clonorchiasis endemic areas. [ABSTRACT FROM AUTHOR]

The Neoarchean charnockite of Yinshan Block has been a hot topic into understanding the Precambrian geology of the North China Craton. Although there is a broad consensus that the charnockite is usually related to granulite‐facies metamorphism, its petrogenesis and tectonics still remain controversial. We present a comparative study of the petrography, geochemistry, and geochronology of charnockite and intermediate–basic granulite in the Jining area along the northern margin of the North China Craton. Inclusions within hypersthene in charnockite are used to identify the peak granulite facies mineral assemblage, with the formation of charnockite being attributed to anatexis of the protolith associated with this granulite‐facies metamorphism. Anatexis occurred mainly during postpeak isothermal decompression, as inferred from the metamorphic evolution and pressure–temperature conditions (granulite and charnockite record peak pressure–temperature conditions of 750°C–1,000°C and 0.8–1.2 GPa and 850°C–975°C and 0.9–1.0 GPa, respectively) derived from analyses of metamorphic minerals using electron probe microanalysis, combined with previous zircon geochronology. Hypersthene in charnockite is interpreted to be a residual or peritectic mineral phase that was present during anatexis, and the charnockite is inferred to have been crystallized from a melt containing abundant residual minerals. Charnockite has similar geochemical characteristics to those of intermediate–basic granulite but differs in several key ways: (a) The charnockite is strongly depleted in the large‐ion lithophile element Cs, the heat‐producing elements U and Th, and the high‐field‐strength elements Nb, Ta, P, and Ti; (b) it is enriched in Sr; and (c) it exhibits both positive and negative Eu anomalies, which are characteristics of granites formed largely by in situ anatexis. Geochemical constraints indicate that the intermediate charnockite and retrograde metamorphic biotite–hornblende gneiss may both be the product of mantle‐derived magma in a magmatic subduction‐related back‐arc extensional environment. This setting provided a hot spot for metamorphic anatexis, with additional heat being provided by the upwelling of asthenospheric mantle. After the cessation of subduction by ~2,470 Ma, a magmatic arc extensional setting developed in the Jining area. The charnockite was involved in Paleoproterozoic orogenesis in the North China Craton and was strongly modified by a ~1,950‐Ma metamorphism event. [ABSTRACT FROM AUTHOR]

Northeast (NE) China is characterized by large areas of Mesozoic and Paleozoic granitoids, whereas Cenozoic granitoids are scarce. This paper reports LA-ICP-MS zircon U-Pb ages and whole-rock geochemical data for late Paleocene-early Eocene granitoids from the Jiamusi Massif, NE China, in order to determine their petrogenesis and tectonic implications. Geochronological data indicate that the granodiorite and dioritic porphyry from the Wudingshan pluton formed at 51.5 ± 0.3 Ma and 56.3 ± 0.8 Ma, respectively. The biotite-quartz diorite, biotite granodiorite, and dioritic porphyry have high SiO2 (68.38-70.06 wt.%), Al2O3 (15.34-15.79 wt.%), and Na2O (3.96-4.49 wt.%) contents, low MgO contents (1.10-1.26 wt.%), A/CNK ratios of 0.99-1.11, and are classified as medium- to high-K calc-alkaline and weakly peraluminous I-type granitoids. They are enriched in LREEs and LILEs, and depleted in HFSEs, with Nb/Ta ratios of 10.4-15.0. Moreover, they have negative Nb-Ta-Ti anomalies, indicating that they were derived from continental crust. Combining with the previously published isotopic data and regional geological results, we suggest that the late Paleocene-early Eocene granitoids (56-52 Ma) were probably derived from partial melting of juvenile lower crust, and formed in an active continental margin setting, possibly related to subduction slab rollback of the Paleo-Pacific Plate. [ABSTRACT FROM AUTHOR]

During 1989-2011, three parasitic disease surveys were conducted in Hengxian County, China, where soil-transmitted helminthiases and foodborne clonorchiasis are endemic. We compared the data and found that the prevalence of helminthiases decreased and the prevalence and intensity of clonorchiasis increased over time, especially among men. Clonorchiasis control/intervention measures are urgently needed in this area. [ABSTRACT FROM AUTHOR]

Background: The present study aimed to estimate the up-to-date prevalence of metabolic syndrome and its relationship with physical activity among suburban adults in Beijing, China. Methods: A cross-sectional survey in a representative sample of 19,003 suburban adults aged 18-76 years was carried out in 2007-2008. Data was collected via questionnaires and blood pressure, anthropometric, and laboratory measurements. Results: Of the residents aged 18-76 years in suburban Beijing, 25.9% (27.3% in men and 25.1% in women), 21.3% (19.4% in men and 22.9% in women), and 25.3% (24.2% in men and 26.1% in women) had 1 component, 2 components, and 3 or more components of metabolic syndrome, respectively. The age-standardized prevalence of metabolic syndrome and its components, including abdominal obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, elevated blood pressure, and elevated fasting plasma glucose, decreased across categories with increasing physical activity. After adjusting for age, sex, education level, smoking, and alcohol consumption, residents were more likely to have metabolic syndrome across categories with decreasing physical activity; a similar relationship also applied to components of metabolic syndrome. Conclusion: A high prevalence of metabolic syndrome and its components is commonly present in suburban Beijing. Increasing physical activity can reduce the relative risk of metabolic syndrome and it components. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Abstract: Although Chinese cobra snakebite is the most common type of snake venenation in China, it still lacks a comprehensive and systematic description. Hence, we aimed to study Chinese cobra bite cases with particular attention to demography, epidemiology and clinical profile. In this study, a total of 292 cases of Chinese cobra snakebite, presenting between January 1, 2008 and December 31, 2012, were retrospectively reviewed. To investigate the effect of treatment at different presentation times (time from snakebite to admission), the patients were divided into two groups: group A included 133 cases that presented <12h after the bite; group B included 159 cases that presented ≥12h after the bite. To assess the correlation between application of a tourniquet and skin grafting, the cases were re-divided into two groups according to whether or not a tourniquet was used after the snakebite: tourniquet group (n =220) and non-tourniquet group (n =72). The results showed that Chinese cobra snakebites were most commonly seen during the summer, in the upper limbs, and in males, young adults, and snake-hunters. Group A experienced milder intoxication than group B (P <0.001). The rate of skin grafting was significantly higher in the tourniquet group (20.0%, compared with 9.7% in the non-tourniquet group, P <0.05). The results of this study indicate that anti-cobra venom and swift admission (within 12h of the snakebite) are recommended for Chinese cobra snakebite. Tourniquet use is not recommended. [Copyright &y& Elsevier]

Background: Clonorchiasis caused by ingesting improperly prepared fish ranks among the most important but still neglected food-borne parasitic diseases, especially in the People's Republic of China (P.R. China). To promote the implementation of interventions efficiently, the demonstration of an epidemiological profile of Clonorchis sinensis infection is essential in hyper-epidemic areas. Methods: In one community with higher levels of economic development in Guangdong province, P.R. China, villagers were motivated to provide stool samples for examining helminth eggs. Then, those infected with C. sinensis completed the structured questionnaire including demographical characteristics, knowledge and behavior. Results: A total of 293 villagers infected with C. sinensis participated in questionnaire investigation. Among them, 94.54% were adult and 93.17% were indigenous. The geometric mean of C. sinensis eggs per gram of feces in the children, adult females and adult males was 58, 291 and 443, respectively. The divergence between knowledge and behavior in the adults, especially the adult males, was shown. Out of 228 persons eating raw fish, 160 did it more frequently at restaurants, the proportion of which varied in different populations, showing 25.00%, 54.88% and 80.28% in the children, adult females and adult males, respectively. Conclusions: Different interventions need to be adopted in different populations. Chemotherapy should be prioritized in the adults, especially the adult males. In addition, health education targeting the children, is essential and may play a crucial role in controlling clonorchiasis in the long term. In order to successfully control clonorchiasis, intervention in the restaurant should not be overlooked in some endemic areas. [ABSTRACT FROM AUTHOR]

Soil-transmitted helminthiases (STHs) are caused by a group of intestinal nematode infections due to poor hygiene and environments, and clonorchiasis is a food-borne trematode (FBT) infection caused by ingestion of raw freshwater fish. Both are endemic in the People's Republic of China. To explore a suitable control strategy, integrated interventions were applied between 2007 and 2009 in ten pilot counties (eight for the STHs and two for clonorchiasis). Drug administration was used for treatment and complementary efforts to improve the situation based on health education, provision of clean water and sanitation were carried out. Significant achievements were gained as reflected by a drastic decrease in prevalence these infections were demonstrated. The overall prevalence of STHs and clonorchiasis decreased from 35.9% to 7.8% and from 41.4% to 7.0%, respectively. The reduction of prevalence and high cost-effectiveness were documented supporting large-scale application of this integrated intervention in China and elsewhere. [ABSTRACT FROM AUTHOR]

Clonorchis sinensis infection is caused by ingestion of raw freshwater fish containing the infective larvae of Clonorchis sinensis. It is highly endemic in East Asia, especially in China. Selective chemotherapy of people who report habitual eating of raw freshwater fish is a control measure. As the performance of this screening technique has not yet been fully evaluated in China, a cross-sectional study was conducted, covering 17 counties in four major clonorchiasis-endemic provinces. About 1 000 participants were enrolled from each county. Fecal samples were collected and examined for helminth eggs and each person enrolled was asked about their practice with respect to eating raw freshwater fish. In total, 16 230 participants from 16 counties were finally included. The overall prevalence of C. sinensis infection was 10.8%, ranging from 0 to 53.7% in the 16 counties, while the percentage of inhabitants eating raw freshwater fish was 26.5%, ranging from 0 to 79.1%. The overall sensitivity and specificity of screening for C. sinensis infection in this approach was 82.3% and 80.3%, respectively, yielding a Youden's index of 0.6. The overall positive and negative likelihood ratios were 4.2 and 0.2, respectively, while the overall positive and negative predictive values were 33.5% and 97.4%, respectively. Furthermore, the sensitivity was higher with regard to high-intensity infections compared to light infections. [ABSTRACT FROM AUTHOR]

Soil-transmitted helminths (STHs) are widely distributed and remain a public health problem in the People's Republic of China. Altogether, 301 counties across 30 regions were investigated during the national surveillance on STHs carried out in 2016 based on the modified Kato-Katz thick smear method to examine faecal samples. A total of 305 081 people were investigated with 7 366 (2.4%) found to be infected. The infection rates were the following: hookworm 1.4%, Ascaris lumbricoides 0.8% and Trichuris trichiura 0.5%. Having established that the STHs infection rate is relatively low, it is time to move towards elimination. The national surveillance system is essential for providing basic data and formulation of useful control strategies towards achieving this goal. [ABSTRACT FROM AUTHOR]

Clonorchiasis is an important food-borne parasitic disease in China, and infection with C. sinensis can cause hepatobiliary diseases. Comprehensive and systematic prevention and control of clonorchiasis requires the establishment of an effective surveillance. A total of 301 surveillance points were set up in 30 provinces across China in 2016, and 1000 people were selected by cluster sampling at each surveillance point annually for C. sinensis infection screening using Kato-Katz thick smear method. C. sinensis infection was detected in 6226 people following screening of 305081 people at the 301 surveillance points in 2016. Infection rate was 2.04%; with C. sinensis infection detected in 70 counties spread across 15 provinces, 89.37% of the infected people were distributed in Jilin, Heilongjiang, Guangdong and Guangxi provinces. Highest infection rate was observed in Da'an city, Jilin Province (49%). The national infection rate in male and female was 2.70% and 1.40% respectively. Infection rate between male and female was significantly different (P <0.01). Disease prevalence increases with age in both male and female, reaches peak in age group 40–49. Result obtained indicate that major C. sinensis endemic areas are distributed in the north and south of China, and areas with high prevalence are distributed along the river system at county level. Result, also, shows that middle-aged men are at high-risk of infection. These results suggest that surveillance activities should be sustained nationwide and highlight the need for an integrated approach to control C. sinensis transmission in regions with high disease prevalence in China. [ABSTRACT FROM AUTHOR]

Background: Cysticercosis is spreading all over the world and it is a major health problem in most countries of Latin America, Africa, and Asia. Extensive disseminated cysticercosis is relatively rare and fewer than 120 case have been reported in the worldwide. We reported a rare case of extensive disseminated cysticercosis in Yunan province, China.Case Presentation: A rare case of extensive disseminated cysticercosis, in a 61-year-old male Chinese was detected from Yunnan province in 2018. Clinical and etiological examination was performed, as well as the epidemiological investigation.Conclusion: The life cycle of T. solium in the area where the case came from is complete. We expect this case could raise the attentions to the control of Taenia solium infection and subsequent cysticercosis there. [ABSTRACT FROM AUTHOR]