1. Diet-omics in the Study of Urban and Rural Crohn disease Evolution (SOURCE) cohort.
- Author
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Braun T, Feng R, Amir A, Levhar N, Shacham H, Mao R, Hadar R, Toren I, Algavi Y, Abu-Saad K, Zhuo S, Efroni G, Malik A, Picard O, Yavzori M, Agranovich B, Liu TC, Stappenbeck TS, Denson L, Kalter-Leibovici O, Gottlieb E, Borenstein E, Elinav E, Chen M, Ben-Horin S, and Haberman Y
- Subjects
- Humans, Male, Female, China epidemiology, Adult, Israel epidemiology, Metabolomics, Cohort Studies, Middle Aged, Feces microbiology, Ileum microbiology, Ileum metabolism, Transcriptome, Young Adult, Crohn Disease microbiology, Crohn Disease genetics, Diet, Gastrointestinal Microbiome, Rural Population, Urban Population
- Abstract
Crohn disease (CD) burden has increased with globalization/urbanization, and the rapid rise is attributed to environmental changes rather than genetic drift. The Study Of Urban and Rural CD Evolution (SOURCE, nā=ā380) has considered diet-omics domains simultaneously to detect complex interactions and identify potential beneficial and pathogenic factors linked with rural-urban transition and CD. We characterize exposures, diet, ileal transcriptomics, metabolomics, and microbiome in newly diagnosed CD patients and controls in rural and urban China and Israel. We show that time spent by rural residents in urban environments is linked with changes in gut microbial composition and metabolomics, which mirror those seen in CD. Ileal transcriptomics highlights personal metabolic and immune gene expression modules, that are directly linked to potential protective dietary exposures (coffee, manganese, vitamin D), fecal metabolites, and the microbiome. Bacteria-associated metabolites are primarily linked with host immune modules, whereas diet-linked metabolites are associated with host epithelial metabolic functions., (© 2024. The Author(s).)
- Published
- 2024
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