1. A unique macrolactam derivative via a [4+6]-cycloaddition from Streptomyces niveus.
- Author
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Li, Liya, Cai, Yaping, Jiang, Yi, Liu, Jiang, Ma, Jian, Yuan, Chunhui, Mu, Yu, Han, Li, and Huang, Xueshi
- Subjects
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RING formation (Chemistry) , *STREPTOMYCES , *FERMENTATION , *FOREST soils , *NUCLEAR magnetic resonance spectroscopy - Abstract
One new macrolactam derivative, nivelactam ( 1 ) and one new polyenoic acid derivative, niveamide ( 2 ), along with two other known 20-atom macrolactams ( 3 and 4 ) were isolated from the fermentation broth of Streptomyces niveus , which obtained from the forest soil in northeastern China. The structures of 1 and 2 were elucidated on the basis of HRESIMS, IR, and NMR spectroscopic data analyses. Compound 1 was proposed as an intramolecular [4+6]-cycloaddition product of 3 by S. niveus , and displayed moderate cytotoxic activity against a panel of human tumor cell lines in vitro, with IC 50 values ranging from 3.76 ± 0.58 to 15.02 ± 2.81 μM. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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