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This article investigates the correlation between emotion and eventual identity change of five teachers learning drama for ELT, a project that involved the author as a drama expert and researcher. It argues that the participants' attribution patterns, regulated by their teaching beliefs, lead to particular emotional responses to the teaching situations, which in turn leads to certain teaching behaviours. Identity change is only possible if the emotion-attribution-action pattern is subverted. Such subversion is unlikely to happen unless emotions are expressed and held for reappraisal, and when teachers are emotionally affected from within during the learning and implementation process.

Infectious bronchitis virus (IBV) is responsible for avian infectious bronchitis, a disease prevalent in countries with intensive poultry farming practices. Given the presence of multiple genotypic strains in China, identifying the regionally dominant genotypes is crucial for the implementation of effective prevention and control measures. This study focuses on the IBV strain CK/CH/WJ/215, isolated from a diseased commercial chicken flock in China in 2021. The CK/CH/WJ/215 isolate was genetically characterized through complete S1 sequence analysis. Phylogenetic comparisons were made with prevalent vaccine strains (H120, LDT3-A, and 4/91). Glycosylation patterns in the S1 protein were also analyzed. Pathogenicity was assessed in 7-day-old specific-pathogen-free chicks, monitoring morbidity, mortality, and tissue tropisms. Phylogenetic analysis clustered the CK/CH/WJ/215 isolate within the GI-19 lineage. Identity with the vaccination strains H120, LDT3-A, and 4/91 was low (75.7%, 78.6%, and 77.5% respectively). Novel glycosylation sites at positions 138 and 530 were identified compared to H120 and LDT-A. The isolate demonstrated nephropathogenic characteristics, causing 100% morbidity and 73.3% mortality in SPF chicks, with broader tropisms in tissues including trachea, lungs, kidneys, and bursa of Fabricius. Comprehensive genetic and pathological investigations revealed significant differences between the CK/CH/WJ/215 isolate and common vaccine strains, including novel glycosylation sites and a strong multiorgan infective capability. These findings are crucial for understanding the evolutionary dynamics of IBV and developing more effective prevention and control strategies. [ABSTRACT FROM AUTHOR]

To understand the effect of the spontaneous imbibition (SI) and waterflooding on oil recovery in the tight sandstone reservoirs, we selected three pairs of tight sandstone samples from the Ordos Basin in China to conduct the SI-plus-waterflooding and waterflooding-only experiments, and monitor the oil distribution and flow characteristics by using the low-field nuclear magnetic resonance (NMR) technology. One interesting observation was that oil extracted in the SI process mainly comes from macropores and micropores, which doesn't agree with the previous results wherein oil was produced from micropores, and oil was produced from the mesopores during the waterflooding after the SI process. The oil recovery factor of tight sandstone samples in the process of the SI-plus-waterflooding was more than 50%, and even more than 85%, which was greater than that in the waterflooding-only process. Moreover, we found that our tight sandstone samples behaved lower residual oil saturation, and wider oil-water two-phase co-flow region during the SI-plus-waterflooding process than that did during the waterflooding-only process. These differences in behavior appear to be linked to the fluid dynamic characteristics and capillary pressure acting on the flow fluid during the two processes. In summary, the SI-plus-waterflooding overcame the limitations related to waterflooding-only and further improved oil recovery factor in the tight sandstones. [ABSTRACT FROM AUTHOR]

In China, liquid residue was mostly found in sealed bronze vessels associated with alcohol drinks, which are supposed to conserve the complete composition of the beverage, including the additives. So far, most of them have not been sufficiently scientifically verified. In this study, the liquid residue in bronze jars from the late Western Han period in the burial area of Jin Yang ancient city site was investigated by GC/MS, LC–MS/MS, SEM and Raman spectroscopy. These sensitive versatile techniques had unintended consequences in addition to confirming the presence of fermentation products (monosaccharides, alditols, glycerol‐related substances and organic acids). The enrichment of oxalic acid, VLCFA (very‐long‐chain fatty acid), and alkaloids hints that multiple plants were involved in the beverage preparation. The quinazoline alkaloid products from the sediments reveal an important Rutaceae ingredient, which relates to multiple ancient spices and Chinese herbs. Therefore, the liquid residues from Jin Yang ancient city site imply that they are the earliest known herbal wine remains in East Asia to this day. [ABSTRACT FROM AUTHOR]

The Beibu Gulf (Gulf of Tonkin, Vinh Bac Bo in Vietnamese), located midway along the East Asian-Australasian Flyway (EAAF), is a critical stopover and wintering region for migratory waterbirds. This transboundary coastal region, spanning between China and Vietnam, harbors diverse wetland habitats that provide refuge to waterbird species, including highly threatened species such as the spoon-billed sandpiper (CR) and the black-faced spoonbill (EN). However, the scarcity of comprehensive assessments regarding waterbird abundances, distribution, key wetland habitats, and regional threats hinders our understanding of its conservation significance at the flyway level. Further research is needed to address these knowledge gaps and facilitate effective conservation efforts in the Beibu Gulf. By synthesizing accessible citizen science datasets and published records from wetland sites in south China and northeast Vietnam, we concluded that at least 97 waterbird species used the Gulf's wetlands during their annual cycle. Among surveys conducted from 2014 to 2022, 5 and 11 waterbird species were considered as first and second class protected species under the National Key Protected Wild Animal List in China; 2 species were listed as Critically Endangered on the IUCN Red List, 4 as Endangered and 2 as Vulnerable, underlying the critical importance of the Beibu Gulf for the survival of these species. Our study identified 25 sites in the Beibu Gulf that met the criteria for designation as internationally important wetlands. Alarmingly, less than a quarter (n = 5, or 20%) of these sites benefit from national or international protection. Localized threats, including aquatic resource harvesting, hunting, and aquaculture/fisheries, were widespread in the region. This study provides a crucial scientific baseline for continued waterbird monitoring, site prioritization, and the development of effective habitat management plans to conserve vital coastal wetland habitats in the Beibu Gulf in China and Vietnam. [ABSTRACT FROM AUTHOR]

Four new phloroglucinol derivatives (1 − 4) were isolated from the leaves of Syzygium fluviatile. Their structures were elucidated by means of extensive spectroscopic data. Among them, compounds 1 and 3 showed significant inhibitory activity against α-glucosidase with IC50 values of 10.60 and 5.07 µM, respectively. The structure-activity relationship was also discussed briefly. [ABSTRACT FROM AUTHOR]

Introduction: Neonatal lupus erythematosus (NLE) is a rare autoimmune disease that causes transient impairment of multi-organ functions and is mainly caused by maternally transmitted antibodies. Objective: This study aims to investigate the clinical features of infants with NLE, focusing on the presence of neurological and endocrinological involvement. Methods: The clinical data of infants diagnosed with NLE at the Children's Hospital of Soochow University from 2011 to 2022 were collected and retrospectively analyzed. Result: In all, 39 patients with NLE were included, and the most common symptom was rash, followed by hematological, hepatic, cardiac, gastrointestinal, neurological, and endocrine symptoms. Among the 10 patients with neurological impairment, intracranial hemorrhage was the most common, followed by convulsions, hydrocephalus, extracerebral space enlargement, and aseptic meningitis. All patients with neurological impairment were positive for anti-SSA/Ro antibodies. Five of these patients were double positive for anti-SSA/Ro and anti-SSB/La antibodies. All 10 patients had multi-organ system involvement, with hematological involvement being the most common, and three patients had varying degrees of developmental delay at the post-discharge follow-up. Nine patients with endocrine impairment were positive for anti-SSA/Ro antibodies, with pancreatic impairment being the most common. There were four cases of hyperinsulinemia and hypoglycemia, one case of diabetes mellitus with ketoacidosis, two cases of hypothyroidism, one case of hypoadrenocorticism, and one case of lysinuric protein intolerance, all of which were normalized before discharge. All patients with endocrine impairment showed hematological involvement, and some showed feeding intolerance as their first symptom. One patient had abnormal liver function at post-discharge follow-up, and two patients had a rash caused by a severe allergy to milk protein. Conclusions: At our hospital, no significant gender differences were observed in the occurrence of NLE, and a predominance of skin, blood, liver, and heart involvement was observed. Patients with multiple central nervous system injuries and organ involvement are more likely to have growth retardation. Endocrine disorders are transient in NLE patients, and some showed feeding intolerance as the first manifestation. Key Points •A retrospective investigation of the clinical characteristics and prognosis of 39 NLE patients was performed, focusing on the clinical features of patients with neurological and endocrine system involvement to improve clinicians' understanding of this disease. [ABSTRACT FROM AUTHOR]

Environmental regulation (ER) and industrial agglomeration (IA) are important factors that affect green development efficiency (GDE). However, there is a lack of studies on their relation in the context of the marine economy. This paper integrates ER, IA, and marine GDE (MGDE) into a unified analytical framework and uses balanced panel data from China's 11 coastal provinces during 2008–2019 to quantify the linear, nonlinear, and spatial spillover effects between the three using the spatial Durbin model (SDM) and threshold effect model. The results show that ER has a negative impact on local and surrounding MGDE through the direct and spatial spillover effects. IA has a positive impact on local and surrounding MGDE through direct and spatial spillover effects. The synergistic impact of ER and IA can significantly boost local and surrounding MGDE. When ER surpasses a certain threshold, it amplifies the positive impact of IA on MGDE. These findings offer theoretical and practical references for the Chinese government to formulate marine environmental governance and industrial development policies. [ABSTRACT FROM AUTHOR]

The original description of Natrix leonardi (currently Rhabdophis leonardi) by Frank Wall in 1923, based on a specimen from the "Upper Burma Hills," lacked important morphological details that have complicated the assignment of recently collected material. Furthermore, although the holotype was never lost, its location has been misreported in one important taxonomic reference, leading to further confusion. We report the correct repository of the holotype (Natural History Museum, London), together with its current catalog number. We also describe key features of that specimen that were omitted from the original description, and provide new details on the morphology of the species, including sexual dichromatism unusual for the genus, based upon specimens from southern Sichuan, China. Rhabdophis leonardi is distinguished from its congeners by the following characters: 15 or 17 DSR at midbody and 6 supralabials; distinct annulus around the neck, broad and red in males, and narrow and orange with a black border in females; dorsal ground color light green or olive; some lateral and dorsal scales possessing black edges, the frequency of black edges gradually increasing from anterior to posterior, forming irregular and ill‐defined transverse black bands; eye with prominent green iris; black ventral spots with a red edge, most numerous at midbody but extending halfway down the length of the tail. In southwestern China, this species is frequently found at 1730–2230 m elevation. It has been documented to prey upon anuran amphibians, including toads. A recently published phylogenetic analysis showed this species to be deeply nested with the genus Rhabdophis, as a member of the R. nuchalis Group. That analysis also revealed the existence of two closely related but geographically distinct subclades in the molecular analysis, one of which may represent an unnamed taxon. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the effects of transcutaneous electrical acupoint stimulation (TEAS) on upper limb motor recovery during post-stroke rehabilitation. Design: Single-blind, randomized controlled trial. Setting: Four inpatient rehabilitation facilities. Subjects: A total of 204 stroke patients with unilateral upper limb motor impairment were randomly 1:1 allocated to TEAS or sham TEAS group. Baseline demographic and clinical characteristics were comparable between the two groups. Interventions: Both groups received conventional physical and occupational therapies. TEAS and sham TEAS therapy were administered to two acupoints (LI10 and TE5) with a pulse duration of 300 µ s at 2 Hz on the affected forearm for 30 times over 6 weeks. Outcome measures: The upper-extremity Fugl-Meyer score (primary outcome), manual muscle testing, modified Ashworth scale, Lindmark hand function score, and Barthel index were evaluated by blinded assessors at baseline, 2, 4, 6, 10, and 18 weeks. Results: The number of patients who completed the treatment was 99 and 97 in the TEAS and the sham group. No significant between-group difference was found in the Upper-Extremity Fugl-Meyer score, Modified Ashworth Scale, Lindmark hand function score, and Barthel Index after intervention and during follow-up. However, the TEAS group exhibited 0.29 (95% CI 0.02 to 0.55) greater improvements in Manual Muscle Testing of wrist extension than the sham group (p = 0.037) at 18 weeks. Conclusions: Administration of TEAS therapy to hemiplegic forearm could not improve the upper extremity motor recovery. However, TEAS on the forearm might provide potential benefits for strength improvement of the wrist [ABSTRACT FROM AUTHOR]

The wetlands in the middle and lower reaches of the Yangtze River are the main overwintering and perching places for cranes. To examine the habitat selection mechanism of cranes in this area, two natural wetland reserves, Shengjin Lake and Poyang Lake, which are the main habitats of typical cranes, were selected as the study area. Using 20 years of Landsat satellite image data (between 1999 and 2019), the vegetation cover index was calculated from a pixel dichotomy model, and the landscape pattern index was obtained through Fragstats. The entropy method was adopted to determine the weight of the landscape index, and then, the habitat suitability index was calculated. Combined with the number of typical crane populations in the reserve, the selection mechanism of overwintering habitat of cranes was revealed. On the change of land-use type, the crane habitat of Shengjin Lake transferred more to non-crane habitat, and other land types increased, resulting in the decrease of crane habitat area. However, the change of crane habitat in Poyang Lake Reserve was small, so it can accommodate more cranes to overwintering here. In terms of vegetation coverage, most of the vegetation cover areas of Shengjin Lake were woodland near or far from the lake, but the woodland was not the habitat of cranes. Most of the vegetation-covered areas of Poyang Lake are grassland near the lake, which provide rest and foraging places for cranes. In the landscape pattern, the number of landscape patches in Shengjin Lake was large, the degree of landscape fragmentation was higher than that in Poyang Lake, the landscape complexity was higher, and the landscape diversity was simpler. This is not conducive to the maintenance of crane habitat, but also reduces the attractiveness of overwintering cranes, while the landscape suitability of crane habitat in Poyang Lake was higher than that in Shengjin Lake, and cranes were more likely to choose Poyang Lake as their overwintering habitat. [ABSTRACT FROM AUTHOR]

Simple Summary: Cobras (Naja Laurenti, 1768) are a group of well-known highly venomous snakes, which cause numerous cases of snakebites every year, especially in South Asia and Southern China. Taxonomic framework is essential for the medical treatment of snake bites and accurate antivenin development. However, the taxonomy of Asian cobras is still puzzling, especially for the widespread species Monocled Cobra (N. kaouthia Lesson, 1831). This study provided new materials and understanding for the taxonomy of this species by combining mitochondrial phylogenetic analysis and morphological comparisons based on samples from a vast area in Asia. The results showed that the Chinese population of N. kaouthia represents a new species. This study also provided new data for N. atra and designated a neotype for it. Furthermore, the subspecies N. naja polyocellata was resurrected and recognized as a full species, N. polyocellatacomb. nov., and the subspecies N. sumatrana miolepis was also resurrected. This study highlighted the necessity to evaluate the effectiveness of cobra antivenin based on a comprehensive taxonomic framework. Taxonomic frameworks for medically important species such as cobras (genus Naja Laurenti, 1768; Squamata, Elapidae) are essential for the medical treatment of snake bites and accurate antivenin development. In this paper, we described the former N. kaouthia populations recorded from China as a new species and designated a neotype for N. atra-based morphological and mitochondrial phylogenetic analysis. The new species N. fuxisp. nov. was morphologically diagnosed from N. kaouthia by (1) regular single narrow crossband present on the middle and posterior parts of the dorsum (3–15, 7.9 ± 2.7, n = 32) and the dorsal surface of the tail (1–6, 4.2 ± 1.1, n = 32) of both adults and juveniles, buff-colored with dark fringes on both edges, vs. South Asian populations (n = 39) and Southeast Asian populations (n = 35) without cross bands, with irregular cross bands or multiple light-colored crossbands pairs, or densely woven lines; (2) small scales between the posterior chin shields, usually three (40%) or two (37%), rarely four (13%), or one (10%) (n = 30) vs. mostly one (81%) and rarely two (19%) (n = 28); (3) ventrals 179–205 (195.4 ± 6.7, n = 33) vs. South Asian populations 179–199 (188.7 ± 5.9, n = 12); Southeast Asian populations 168–186 (177.8 ± 4.9, n = 18). Phylogenetically, the new species forms an independent sister clade to the clade including N. atra, N. kaouthia, N. oxiana and N. sagittifera. Furthermore, the subspecies N. naja polyocellata should be resurrected and recognized as a full species, N. polyocellatacomb. nov., and the subspecies N. sumatrana miolepis should be resurrected. [ABSTRACT FROM AUTHOR]

Background: FOXG1-related encephalopathy, also known as FOXG1 syndrome or FOXG1-related disorder, affects most aspects of development and causes microcephaly and brain malformations. This syndrome was previously considered to be the congenital variant of Rett syndrome. The abnormal function or expression of FOXG1, caused by intragenic mutations, microdeletions or microduplications, was considered to be crucial pathological factor for this disorder. Currently, most of the FOXG1-related encephalopathies have been identified in Europeans and North Americans, and relatively few Chinese cases were reported. Methods: Array-Comparative Genomic Hybridization (Array-CGH) and whole-exome sequencing (WES) were carried out for the proband and her parent to detect pathogenic variants. Results: A de novo nonsense mutation (c.385G>T, p.Glu129Ter) of FOXG1 was identified in a female child in a cohort of 73 Chinese children with neurodevelopmental disorders/intellectual disorders (NDDs/IDs). In order to have a comprehensive view of FOXG1-related encephalopathy in China, relevant published reports were browsed and twelve cases with mutations in FOXG1 or copy number variants (CNVs) involving FOXG1 gene were involved in the analysis eventually. Feeding difficulties, seizures, delayed speech, corpus callosum hypoplasia and underdevelopment of frontal and temporal lobes occurred in almost all cases. Out of the 12 cases, eight patients (66.67%) had single-nucleotide mutations of FOXG1 gene and four patients (33.33%) had CNVs involving FOXG1 (3 microdeletions and 1 microduplication). The expression of FOXG1 could also be potentially disturbed by deletions of several brain-active regulatory elements located in intergenic FOXG1-PRKD1 region. Further analysis indicated that PRKD1 might be a cooperating factor to regulate the expression of FOXG1, MECP2 and CDKL5 to contribute the RTT/RTT-like disorders. Discussion: This re-analysis would broaden the existed knowledge about the molecular etiology and be helpful for diagnosis, treatment, and gene therapy of FOXG1-related disorders in the future. [ABSTRACT FROM AUTHOR]

With the wide use of carbapenems, carbapenem-resistant Enterobacterales have been increasingly reported worldwide. In this study, one blaOXA-181-positive Pseudocitrobacter faecalis strain was isolated from the blood culture of a patient with a bloodstream infection in China, which was its first clinical report outside Pakistan. Species identification of P. faecalis was initially performed using MALDI-TOF/MS and further confirmed by 16S rRNA gene and housekeeping gene sequencing. The antimicrobial susceptibility testing was determined through the broth microdilution method, and their clonal relationship was analyzed by pulsed-field gel electrophoresis. To study the transmission and genetic structure of the blaOXA-181 gene, a transformation test and whole-genome sequencing (WGS) were performed. The results of the antimicrobial susceptibility testing indicated this P. faecalis was resistant to carbapenems, quinolones, and commonly used β-lactam/β-lactamase inhibitor combinations. Through WGS and transformation experiments, blaOXA-181 and qnrS1 genes causing antibiotic resistance were located on a 55,148-bp length IncX3 type plasmid with a truncated ColKp3 replicon gene. As a rare species of Enterobacterales, P. faecalis was clinically reported in China for the first time, and the blaOXA-181 gene it carried was located on a globally disseminated IncX3 plasmid. The spread of such bacteria and antibiotic resistance requires more clinical attention. [ABSTRACT FROM AUTHOR]

In order to promote sustainable economic development in the areas along the Belt and Road in China, it is of great necessity to reduce the negative impact of air pollutants resulting from industrialization and urbanization on the complex and fragile ecological environments of neighboring areas. First, this study estimated the total-factor air environmental efficiency (TFAEE) of 17 provinces along the Belt and Road in China from 2010 to 2017 using a slacks-based measure (SBM) model. Second, the global and local Moran indices were used to test the spatial correlations between TFAEEs. Finally, the spatial factors and spatial spillover effects influencing the TFAEEs were investigated using the spatial Durbin model with spatiotemporal double fixed effects. The results were shown as follows: (1) The total-factor TFAEEs of the areas along the Belt and Road were low and showed significant regional spatial differences during 2010–2017. (2) There was a positive spatial autocorrelation between the TFAEEs of the areas along the Belt and Road, and the spatial distribution generally clustered into High-High and Low-Low concentrations. (3) Economic development and technological innovation played significantly positive effects on TFAEEs of the areas in the Belt and Road, while energy consumption structure had negative effect on it. In addition, although industrial structure and environmental regulation were negatively correlated with TFAEEs, the coefficients were not significant. (4) The positive spatial spillover effect of the TFAEEs of the areas along the Belt and Road was mainly the result of significant environmental regulations and insignificant economic development factors, while the technological innovations, energy consumption structures and industrial structures showed insignificant negative spatial spillover effects. [ABSTRACT FROM AUTHOR]

The prevalence of clinical MDR bacteria in China is still high.[6] According to the results in 2021 from the China Antimicrobial Surveillance Network (www.chinets.com; 71 hospitals from 29 provinces or cities), the resistance rates of meropenem-resistant I Klebsiella pneumoniae i , meropenem-resistant I Pseudomonas aeruginosa i and meropenem-resistant I Acinetobacter baumannii i were 24.4%, 18.9% and 72.3%, respectively. China's new national action plan to combat antimicrobial resistance (2022-25). [Extracted from the article]

Objective: To assess the association between vitamin D status and all-cause mortality among type 2 diabetes patients. Research Design and Methods: We prospectively followed 1,291 participants with type 2 diabetes aged 20–80 years during 2013–2018. Cox proportional hazard regression models were used to estimate the association between different vitamin D status and all-cause mortality risk among hospitalized patients with type 2 diabetes. Results: During a median follow-up of 4.15 years (5,365 person-years in total), 61 cases of death were identified. Multivariable-adjusted hazard ratios (HRs) for all-cause mortality across the quartiles of baseline circulating 25-hydroxy vitamin D (25-OH vitamin D) were 2.70 [95% confidence interval (CI) 1.12–6.54], 1.00, 1.39 (95% CI 0.53–3.65), 2.31 (95% CI 0.96–5.54), respectively. Multivariable-adjusted HRs for all-cause mortality by different groups of baseline 25-OH vitamin D concentrations (<25, 25–49, 50–100, and ≥100 nmol/L) were 1.31 (95% CI 0.58–2.96), 0.94 (95% CI 0.47–1.87), 1.00, and 3.58 (95% CI 1.43–8.98), respectively. Conclusions: Very low or high concentrations of vitamin D may be associated with a higher risk of all-cause mortality among patients with type 2 diabetes. [ABSTRACT FROM AUTHOR]

Purpose: OXA-10-type class D β-lactamases have shown their evolutionary potential of enhancing carbapenem resistance. This study aimed to elucidate the role of OXA-10 variants in clinical isolated multidrug resistant (MDR) Pseudomonas aeruginosa and characterize the first appearance of OXA-677 in China. Methods: Six blaOXA-10-like-positive strains were screened by PCR from 41 P. aeruginosa strains, which were resistant to both carbapenems and ceftazidime-avibactam, collected across China in 2018. The minimum inhibitory concentrations (MIC) were determined with the broth microdilution method. The resistance-associated genes and genetic environment were investigated by whole-genome sequencing (WGS). The function and mechanism of OXA-677 β-lactamase were identified by molecular cloning and protein structure modeling. Results: All the blaOXA-10-like-positive Pseudomonas aeruginosa were MDR strains. They also had outer membrane porin defects and produced β-lactam resistance gene blaPER-1, fluoroquinolone-resistant gene crpP, aminoglycoside-resistance gene aph(3ʹ)-IIb, aph(6)-Id, aacA and aadA, fosfomycin-resistance gene fosA, sulfamethoxazole-resistance gene sul1, and chloramphenicol-resistance gene catB7. All blaOXA-10 variants were located in a Tn1403-related transposon, containing aacA4-12-blaOXA-677-aadA1, aacA4-12-blaOXA-101-aadA5, and blaOXA-246-aacA3-aadA13 gene cassette arrays, respectively. Notably, the blaOXA-677 producer showed a high MIC level of meropenem (MIC> 64 mg/L). Compared to blaOXA-10, blaOXA-677 was found a G-to-T transversion at position 350, leading to a phenylalanine-for-valine substitution in position 117, which is closer to leucine155 in the omega loop of the active site. MIC of meropenem for E. coli DH5α with the recombinant plasmid pHSG398 carrying blaOXA-677 was elevated by 8 times. Conclusion: We speculate that the OXA-10-like enzymes and the decrease of membrane permeability confer carbapenem resistance, and the V117 substitution in OXA-677 might lead to a higher resistance level of meropenem. [ABSTRACT FROM AUTHOR]

A new homo-aro-cholestane glycoside parispolyside H, along with nine known compounds, were isolated from 75% ethanolic extract of the rhizome of Paris polyphylla var. chinensis. Their chemical structures were elucidated on the basic of analysis of detailed spectroscopic and physicochemical properties. In addition, the isolated compounds (1, 6-9) were evaluated for their cytotoxic activity against HepG2 human liver cancer cell lines. Among them, four known compounds (6-9) showed cytotoxicity with IC50 values ranging from 0.41 to 3.6 μM. [ABSTRACT FROM AUTHOR]

Sitafloxacin is one of the newer generation fluoroquinolones. Considering the ever-changing antimicrobial resistance, it is necessary to monitor the activities of sitafloxacin against recent pathogenic isolates. Therefore, we determined the minimum inhibitory concentrations (MICs) of sitafloxacin and comparators by broth microdilution or agar dilution method against 1101 clinical isolates collected from 2017 to 2019 in 31 hospitals across China. Sitafloxacin was highly active against gram-positive isolates evidenced by the MICs required to inhibit the growth of 50%/90% isolates (MIC50/90): ≤ 0.03/0.25, ≤ 0.03/0.125, ≤ 0.03/2, 0.125/0.25, 0.25/2, and 0.125/0.125 mg/L for methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-susceptible coagulase-negative Staphylococcus (MSCNS), methicillin-resistant S. aureus (MRSA), methicillin-resistant CNS, Enterococcus faecalis, and Streptococcus pneumoniae, respectively. Sitafloxacin inhibited 82.8% of the MRSA strains and 97.5% of MRCNS strains. Sitafloxacin was also potent against ciprofloxacin-susceptible Escherichia coli (MIC50/90: ≤ 0.03/0.06 mg/L) and Klebsiella pneumoniae (MIC50/90: ≤ 0.03/0.125 mg/L), non-ESBL-producing E. coli (MIC50/90: ≤ 0.03/1 mg/L) and K. pneumoniae (MIC50/90: ≤ 0.03/0.5 mg/L), Haemophilus influenzae (MIC50/90: ≤0.015/0.06 mg/L), Haemophilus parainfluenzae (MIC50/90: 0.125/0.5 mg/L), Moraxella catarrhalis (MIC50/90: ≤ 0.015/≤ 0.015 mg/L), Bacteroides fragilis (MIC50/90: 0.06/2 mg/L), Peptostreptococcus (MIC50/90: 0.125/4 mg/L), and Mycoplasma pneumoniae (≤ 0.03/≤ 0.03 mg/L). However, sitafloxacin was less active for Enterococcus faecium, ciprofloxacin-resistant and/or ESBL-producing E. coli, and K. pneumoniae strains. Sitafloxacin was superior or comparable to most of the comparators in activities against the abovementioned isolates, so sitafloxacin is still highly active against most of the clinical isolates in hospitals across China, proving its utility in treatment of the abovementioned susceptible strains. [ABSTRACT FROM AUTHOR]

Carbapenem-resistant Enterobacterales (CRE) has become a major therapeutic concern in clinical settings, and carbapenemase genes have been widely reported in various bacteria. In Serratia marcescens , class A group carbapenemases including SME and KPC were mostly identified. However, there are few reports of metallo-β-lactamase-producing S. marcescens. Here, we isolated a carbapenem-resistant S. marcescens (S378) from a patient with asymptomatic urinary tract infection which was then identified as an IMP-4-producing S. marcescens at a tertiary hospital in Sichuan Province in southwest of China. The species were identified using MALDI-TOF MS, and carbapenemase-encoding genes were detected using PCR and DNA sequencing. The results of antimicrobial susceptibility testing by broth microdilution method indicated that the isolate S. marc escens S378 was resistant to meropenem (MIC = 32 μg/ml) and imipenem (MIC = 64 μg/ml) and intermediate to aztreonam (MIC = 8 μg/ml). The complete genomic sequence of S. marcescens was identified using Illumina (Illumina, San Diego, CA, United States) short-read sequencing (150 bp paired-end reads); five resistance genes had been identified, including bla IMP–4, bla SRT–2, aac(6′)-Ic , qnrS1 , and tet(41). Conjugation experiments indicated that the bla IMP–4-carrying plasmid pS378P was conjugative. Complete sequence analysis of the plasmid pS378P bearing bla IMP–4 revealed that it was a 48,780-bp IncN-type plasmid with an average GC content of 50% and was nearly identical to pP378-IMP (99% nucleotide identity and query coverage). [ABSTRACT FROM AUTHOR]

Objective. To explore the application of Jianpi Xiaoai recipe combined with cisplatin and Adriamycin in the treatment of endometrial cancer (EC) and its effect on the disease control rate (DCR). Methods. The data of 120 EC patients treated in People's Hospital of Rizhao from February 2019 to February 2020 were retrospectively analyzed. They were equally split into experimental group and control group according to the order of admission. All patients were treated with neoadjuvant intra-arterial chemotherapy (continuous infusion of the uterine artery for 5 days before surgery, with 20 mg of cisplatin mixed with 2000 mg of normal saline and 10 mg of Adriamycin mixed with 500 ml of normal saline daily), while the experimental group was treated with Jianpi Xiaoai recipe at the same time to compare the short-term efficacy, immune function indexes, incidence of adverse reactions, and HEC-1-B (human endometrial adenocarcinoma cells) cell inhibition rates between the two groups. Results. The DCR and objective remission rate (ORR) in the experimental group were markedly higher compared with the control group (P < 0.05). The immune function indexes after treatment were remarkably better in the experimental group than in the control group (P < 0.05). Compared with the control group, the incidence of adverse reactions in the experimental group was notably lower (P < 0.05), while the HEC-1-B inhibition rates after treatment were obviously higher (P < 0.05). Conclusion. Jianpi Xiaoai recipe combined with cisplatin and Adriamycin can increase the HEC-1-B cell inhibition rate in EC patients, improve their immune function, reduce the possibility of adverse reactions, and enhance the therapeutic effect, which is worthy of clinical application and popularization. [ABSTRACT FROM AUTHOR]

Purpose: With the continuous change of research contents and methods of intelligence science, its integration with other disciplines is also deepening. The purpose of this paper is to further explore the interdisciplinary research characteristics of intelligence science in theoretical depth and application value. Design/methodology/approach: This paper summarizes and explores in two aspects. The first is a large number of literature review, mainly combined with the historical characteristics of the development of intelligence science researches in China and international comparison. The second is to refine the discipline construction ideas suitable for the development of contemporary intelligence science. Findings: From the perspective of the historical development of discipline relevance, the development characteristics and positioning of intelligence science in China are introduced, with the comparison of many disciplines including information technology, library science, information science, data science, management science and other disciplines. In order to better meet the practical needs of intelligence service in the new era, this paper mainly analyzes the construction method of intelligence science research system and the relocation of intelligence science research content. Originality/value: This paper summarizes the historical characteristics and international comparison of the development of intelligence science in China. It proposes the development characteristics and orientation of intelligence science in China from the perspective of historical development of discipline relevance. It also proposes the discipline construction ideas suitable for the development of contemporary intelligence science. [ABSTRACT FROM AUTHOR]

In recent years, the emergences of large-scale and high-frequency serious haze weather mainly caused by air pollution in China have aroused widespread concerns at home and abroad, and thus the evaluation of China's air pollution efficiency has become a topic of interest. In this paper, taking 2016 as the study period, we evaluate air pollution efficiency for China's 30 mainland provinces by using an improved context-dependent slack-based measure (SBM) approach considering air pollution as the undesirable output under the total-factor production framework. The results show that utilizing the context-dependent SBM-Undesirable approach to evaluate provincial air pollution efficiency in mainland China is applicable and effective. Compared to other DEA-based approaches, the approach employed in this study can formulate more achievable short-term air pollution reduction targets for each China's inefficient province in air pollution. In addition to this, it can also help confirm optimal learning benchmarks and appropriate benchmark-learning pathways for China's inefficient provinces to combat air pollution. Finally, the conclusions and some related policy recommendations for the improvement of air pollution efficiency and air pollution mitigation in China are put forward. [ABSTRACT FROM AUTHOR]

Through the analysis of the project of gob-side entry retaining in the deep gangue filling 2305S-2# working face of the Xinjulong coal mine, the principle and technology of surrounding rock control of gob-side entry retaining along the deep mining face are discussed. It is found that the use of gangue to fill the goaf of the deep mining face can effectively alleviate the occurrence of violent strata pressure, which is the basis for realizing entry retaining along the goaf. In the Xinjulong coal mine, the gangue wall and concrete-filled steel tube columns are used as roadside support structure. Anchor bolt + W steel belt are used as advance support, monomer column + hinged beam are used as temporary support, and long anchor cable + beam are used as permanent support. Gob-side entry retaining of deep mining working face is successfully realized. The actual measurement results show that the bearing capacity of gangue wall increases slowly, and the deformation is large. The concrete-filled steel tube column has a certain drilling bottom, and the roof cable is easily broken on the side of the remaining roadway. It is necessary to strengthen the lateral constraint of the gangue wall, limit the deformation of the gangue wall, and improve the bearing capacity of the gangue wall. The bottom of the concrete-filled steel tube column needs to be installed with a large backing plate to control the bottom drilling amount, and the roof anchor cable of the roadway must have a certain elongation to realize the coordinated deformation of the anchor cable and the roof. [ABSTRACT FROM AUTHOR]

Ophiopogon japonicus (Thunb.) Ker-Gawl (Liliaceae), which is named as "Maidong" in China, is widely used in traditional Chinese medicine for treating fever, cough, inflammation, epistaxis, constipation, respiratory disease and gastrointestinal disorders. However, the systematic analysis of chemical constituents of O. japonicus has not been well established because of the complexity and trace. In this paper, an effective and reliable high-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry method was successfully developed to separate and identify the chemical constituents from O. japonicus. As a result, a total of 30 compounds including steroidal saponins, homoisoflavonoids, allylbenzene, cholest and cryptomeridiol were screened or tentatively identified. Of them, three new steroidal saponins were found and tentatively characterized in O. japonicus. This study provides a meaningful material basis for further quality control and pharmacological research. [ABSTRACT FROM AUTHOR]

Background: The associations of different adiposity indicators and short-term adiposity change with diabetes risk are not fully elucidated.Objective: We aimed to assess the independent and joint effects of different baseline adiposity indicators and short-term body adiposity change on the risk of type 2 diabetes.Methods: We prospectively followed 10,419 Chinese adults aged 20-80 y in 2008-2012. Incident diabetes was diagnosed based on fasting glucose, 2-h glucose, or glycated hemoglobin (HbA1c) after an oral glucose tolerance test using the American Diabetes Association standard. Cox proportional hazard regression models were used to assess the associations of adiposity indicators and adiposity change with diabetes risk.Results: During a mean follow-up of 2.8 y, we identified 805 type 2 diabetes cases. Baseline BMI, waist circumference, and waist-height ratio (WHtR) were all positively associated with diabetes risk. The area under the curve was significantly greater for waist circumference (0.624) and WHtR (0.627) than for BMI (0.608) (P <0.05). Compared with subjects with stable adiposity levels (±2 kg or ± 3 cm in changes in body weight or waist circumference) from baseline to Year 1, those subjects with the most weight gain or the most waist circumference gain had a 1.53-fold or 1.37-fold greater risk of diabetes; those with the most weight loss had a 46% lower risk of diabetes. Furthermore, regardless of baseline weight status, weight or waist circumference change in the first year was associated with diabetes risk.Conclusion: Abdominal adiposity indicators, waist circumference and its change, are more strongly associated with the risk of type 2 diabetes than general adiposity indicators, BMI, and changes in body weight among Chinese adults. [ABSTRACT FROM AUTHOR]

Background: In China, Jin's three-needle acupuncture therapy has been widely used for stroke treatment. However, its mechanism remains unclear. The aim of this study was to investigate the effects of Jin's three-needle acupuncture therapy on stroke patients using multi-channel EEGs. Materials and methods: Fifty stroke patients participated and their EEG signals were recorded before, during, and after acupuncture. Results: Comparing with baseline before acupuncture, the alpha rhythm was significantly increased during the acupuncture needle retention stage and became stronger after removing the needles. The increase of alpha rhythm occurred when inserting and removing the needles, with its high amplitude remaining during retention and after removal of the needles. As the alpha rhythm was significantly correlated with patients' movement and daily-living abilities, the alteration of alpha rhythm during and after acupuncture suggests a possible electrophysiological mechanism of the curative effect of acupuncture for stroke rehabilitation. Conclusion: From the electrophysiological study, Jin's three-needle acupuncture therapy is efficient in stroke patients. [ABSTRACT FROM AUTHOR]

The current study investigated the concentration of heavy metals (HMs) in human hair associated with fish and rice consumption in Wuhan City, central China. The mean values of As in 8/10 fish species exceeded the food safety standard of 0.015 mg/kg. The mean values (mg/kg) of HMs in rice followed a descending order of Zn (13.7)> Cu (1.9)>Cr (0.51)>As (0.11) >Cd (0.08) >Pb (0.04). The ascending order of HMs for male hair was Cd < As < Cr < Pb < Cu < Zn, while As < Cd < Cr < Pb < Cu < Zn for female. 30% of hair Cr and 22% of hair Zn contents exceeded the recommended values. The middle age (19–44) and adult (45–59) groups were the most vulnerable group, as the concentration for most elements was high in these age groups. A significant correlation was found between fish-eating frequency and hair Zn (r = 0.213; p < 0.05), and As (r = 0.204; p < 0.05). High odd ratios were found in a population with high fish-eating frequency, especially for Pb (7.19), As (3.1), Zn (3.83), and Cd (3.7). A significant non-carcinogenic risk was associated with Cr exposure through consuming herbivores, filter feeders, and omnivorous fish. The cancer risk values of Cd exposure (1.54E-04) via rice consumption and As exposure (1.25E-04) via consumption of omnivores fish indicate precautionary measures. [Display omitted] • As contents in 8/10 fish species exceeded the food safety standards. • Hair Cr (30%) and Zn (22%) concentrations exceeded the recommended values. • Hair heavy metals were generally high in the 19–44 and 45–49 age groups. • A significant correlation was found between fish-eating frequency and hair Zn, and As. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the association between calciumsensing receptor ( CaSR ) Arg990Gly (rs1042636, A > G), Ala986Ser (rs1801725, G > T) polymorphisms, and urolithiasis risk. Methods: Polymorphisms mentioned above were genotyped in a hospital-based case-control study of 615 patients diagnosed with nephrolithiasis and 315 kidney stone- free controls in a Chinese population using the SNaPshot method. Results: The results indicated a significantly increased risk associated with CaSR Arg990Gly GG genotypes (OR 1.64, 95% CI 1.08-2.50) compared with the AA genotype. The CaSR Arg990Gly G carriers (AG/GG) had an adjusted OR (95% CI) of 1.45 (1.04-2.03, p = 0.021) compared with the wild genotype in the dominant model. In the stratified analyses, the risk remained for the subgroup of patients with age >48, never smokers and patients with hypertension and calcium oxalate stones (OR 1.78, 95% CI 1.02-3.09; OR 1.54, 95% CI 1.03-2.30; OR 2.83, 95% CI 1.32-6.07; OR 1.60, 95% CI 1.12- 2.28, respectively). Conclusion: Our results provide evidences that the CaSR Arg990Gly polymorphism is associated with the risk of nephrolithiasis development in a Chinese population. [ABSTRACT FROM AUTHOR]

Background: Candidemia is the worldwide life-threaten disease, especially in cancer patients. This study was aimed to identify and evaluate the risk factors of candidemia in cancer patients, which will prompt the improvement on current therapeutic strategies and prognosis.Methods: A retrospective, case-control study was conducted from inpatients of Tianjin Medical University Cancer Institute and Hospital, during 2006 to 2013. Analyses were performed between cancer patients with candidemia as study case, and patients with bacterial bloodstream infections as control. Each case was matched up with two controls, for gender and inpatient duration. Candida species, clinical characteristics, risk factors and outcomes were reviewed in details.Results: Total number of 80 cases and 160 controls were enrolled and analyzed in this study. Candida albicans was identified as the most prevalent species and account for 55.0% candidemia, followed by Candida parapsilosis complex (21.3%), Candida tropicalis (8.8%), Candida glabrata complex (7.5%), Candida lusitaniae (3.8%), and Candida famata (3.8%). The crude mortality at 30-days of candidemia was up to 30.0%, which is significantly higher than bacterial bloodstream infections (p = 0.006). Logistical analysis demonstrated that total parenteral nutrition >5 days (p = 0.036), urinary catheter >2 days (p = 0.001), distant organ metastasis of cancer (p = 0.002) and gastrointestinal cancer (p = 0.042) were the independent risk factors for candidemia.Conclusions: Candidemia showed significant higher mortality than bacterial bloodstream infections, C. albicans was cited as the primary pathogen. Total parenteral nutrition, urinary catheter, distant organ metastasis of cancer and gastrointestinal cancer are independent predictors for candidemia, this findings provides potential therapeutic targets for improving the outcome. [ABSTRACT FROM AUTHOR]

Cricetulus migratorius is widely distributed in the northwestern arid regions of China. Here, the complete mitochondrial genome (mitogenome) of C. migratorius is reported, to our knowledge, for the first time. It was found to be 16,246 bp in length, including 13 protein-coding genes (PCGs), 2 rRNA genes, 22 tRNA genes, and one control region, and showed characteristics typical of the vertebrate mitogenome. Comparative analyses of mitogenomes of Cricetulus species showed that hamster mitogenomes had the same arrangement and organizational structure. The base composition was AT-rich for all Cricetulus species. We elaborated the PCG sequence and found that the main differences in the start and stop codons were in the ND3 gene; the most frequently used codons were AUU (Ile) and CUA (Leu), and the AT-content at the 3rd position was lower than that at 1st and 2nd positions in all Cricetulus species. The second tRNA ser had lost the dihydrouridine stem-loop structure, which is found in all Cricetulus species. We also elucidated the structure of the control region (the extended termination associated sequences, the central conserved sequences, and the conserved sequence blocks), and the putative origin of replication for the light strand in all Cricetulus species. Based on mitogenome data with four reconstructed methods, phylogenetic trees showed high resolution in the divergent clades within Cricetulus . The results indicated that Cricetulus kamensis is at basal position, and has the earliest split among all Cricetulus species. Cricetulus griseus and Cricetulus longicaudatus clustered in a subclade, and were separate from C. kamensis . As previous studies have shown, Tscherskia triton is part of Cricetulus with high support value. It is noteworthy that C. migratorius is a young species, and has a close relationship with Allocricetulus eversmanni within Cricetulus , which is closer to the subgenus Allocricetulus . [ABSTRACT FROM AUTHOR]

Aims: This study sought to investigate electrocardiographic characteristics, electrophysiological features, and radiofrequency ablation in patients with focal atrial tachycardia (AT) originating from the septal mitral annulus.Methods and Results: In 13 patients with AT originating from the septal mitral annulus, activation mapping was performed to identify the earliest activation site. Successful ablation was performed through either a transseptal (n = 12) or a retrograde aortic approach (n = 1). As confirmed by electrogram recordings, fluoroscopy, and three-dimensional (3D) mapping, successful ablation sites were located in the anterior paraseptal, mid- to anteroseptal, and posterior septal mitral annulus in eight, three, and two patients, respectively. Foci for all locations demonstrated a negative/positive appearance in lead V1. Mapping in the right atrium demonstrated that the earliest right atrial activation was near the septum (His-bundle region or proximal coronary sinus). The electrograms at the successful ablation sites were fractionated in 9 patients, and presented with an atrial:ventricular ratio of <1 in all 13 patients. There were no complications in any patients and long-term success was achieved in 12 of 13 patients during the 23 ± 6 months following ablation.Conclusion: The area surrounding the septal mitral annulus, most commonly the anterior paraseptal, is an unusual, but important site of origin for focal AT, which is associated with a distinctive P-wave morphology and atrial endocardial activation sequence. Radiofrequency ablation of AT originating from the septal mitral annulus, through either a transseptal or a retrograde aortic approach appears to be safe and effective. [ABSTRACT FROM AUTHOR]

Spines or trichomes on the fruit of cucumbers enhance their commercial value in China. In addition, glabrous mutants exhibit resistance to aphids and therefore their use by growers can reduce pesticide residues. Previous studies have reported two glabrous mutant plants containing the genes, csgl1 and csgl2. In the present study, a new glabrous mutant, NCG157, was identified showing a gene interaction effect with csgl1 and csgl2. This mutant showed the glabrous character on stems, leaves, tendrils, receptacles and ovaries, and there were no spines or tumors on the fruit surface. Inheritance analysis showed that a single recessive gene, named csgl3, determined the glabrous trait. An F2 population derived from the cross of two inbred lines 9930 (a fresh market type from Northern China that exhibits trichomes) and NCG157 (an American processing type with glabrous surfaces) was used for genetic mapping of the csgl3 gene. By combining bulked segregant analysis (BAS) with molecular markers, 18 markers, including two simple sequence repeats (SSR), nine insertion deletions (InDel) and seven derived cleaved amplified polymorphism sequences (dCAPs), were identified to link to the csgl3 gene. All of the linked markers were used as anchor loci to locate the csgl3 gene on cucumber chromosome 6. The csgl3 gene was mapped between the dCAPs markers dCAPs-21 and dCAPs-19, at genetic distances of 0.05 cM and 0.15 cM, respectively. The physical distance of this region was 19.6 kb. Three markers, InDel-19, dCAPs-2 and dCAPs-11, co-segregated with csgl3. There were two candidate genes in the region, Csa6M514860 and Csa6M514870. Quantitative real-time PCR showed that the expression of Csa6M514870 was higher in the tissues of 9930 than that of NCG157, and this was consistent with their phenotypic characters. Csa6M514870 is therefore postulated to be the candidate gene for the development of trichomes in cucumber. This study will facilitate marker-assisted selection (MAS) of the smooth plant trait in cucumber breeding and provide for future cloning of csgl3. [ABSTRACT FROM AUTHOR]

This paper investigates the optimal currency composition for a country's foreign reserves. In the context of China, we examine the asymmetric, fat‐tail and complex dependence structure in distributions of currency returns. A skewed, fat‐tailed and pair‐copula construction is then built to capture features of higher moments. In a D‐vine copula approach, we show that under the disappointment aversion effect, the central bank in our model can achieve sizeable gains in expected economic value from switching from the mean‐variance to copula modelling. We find that this approach will lead to an optimal currency composition that allows China to have more space for international currency diversification while maintaining the leading position of the US dollar in the currency shares of China's reserves. [ABSTRACT FROM AUTHOR]

Carbon labeling has been recently developed to lead the public towards lower carbon consumption in an attempt to create a low-carbon economy. By identifying the greenhouse gas emissions produced during the full life cycle of a product, carbon labeling can affect the behavior of the consumers who purchase low-carbon products. Based on data from a carbon-labeling scenario experiment conducted by the research group in six cities throughout China, we adopted the Dunnett's T3 test approach for single factor variance analysis to find the differences in consumers' willingness to pay for low-carbon products between different types of consumers. Then, we used a logistic regression model to analyze the relationship between the consumers' willingness to pay and their demographic variables. The results indicate: (1) significant differences exist in the willingness to pay for low-carbon products for different consumers, and (2) education level and monthly income significantly impact consumer willingness to pay. Based on these findings, we proposed relevant policy implications. [ABSTRACT FROM AUTHOR]

Indica is not only an important rice subspecies widely planted in Asia and the rest of the world, but it is also the genetic background of the majority of hybrid varieties in China. Studies on genetic structure and genetic diversity in indica germplasm resources are important for the classification and utilization of cultivated rice in China. Using a genetically representative core collection comprising 1482 Chinese indica landraces, we analysed the genetic structure, geographic differentiation and diversity. Model-based structure analysis of varieties within three ecotypes revealed nine eco-geographical types partially accordant with certain ecological zones in China. Differentiation of eco-geographical types was attributed to local ecological adaption and physical isolation. These groups may be useful for developing heterotic groups of indica. To facilitate the identification of different ecotypes and eco-geographical types, we identified characteristic SSR alleles of each ecotype and eco-geographical type and a rapid index of discrimination based on characteristic alleles. The characteristic alleles and rapid discrimination index may guide development of heterotic groups, and selection of hybrid parents. [ABSTRACT FROM AUTHOR]

The educational philosophy of Peter H. L. Chang features equality of men and women and emphasis on female education. After coming to power in Northeast of China, Peter H. L Chang broke through the imprisonment on thought to develop female education boldly. He enrolled girl students in all the schools and departments of Northeastern University, which set a new fashion of female higher education in Northeast of China. Meanwhile, he founded TongZe Girls' High School and became its board chairman. Peter H. L. Chang attached such great importance to female education not only because of the background of female education movement brought by Western Learning and women's liberation launched by the May 4th Movement and the New Culture Movement as well as development of female education in Shenyang area, but also due to his advanced educational philosophy and his dream to revitalize Northeast of China, resist foreign aggression and protect China from being occupied. [ABSTRACT FROM AUTHOR]

To understand electromagnetic radiation field strength and its influencing factors of certain 110-kV high-voltage lines in one urban area of Chongqing by measuring 110-kV high-voltage line's electromagnetic radiation level. According to the methodology as determined by the National Hygienic Standards, we selected certain adjacent residential buildings, high-voltage lines along a specific street and selected different distances around its vertical projection point as monitoring points. The levels of electromagnetic radiations were measured respectively. In this investigation within the frequency of 5-1,000 Hz both the electric field strength and magnetic field strength of each monitoring sites were lower than the public exposure standards as determined by the International Commission on Non-Ionizing Radiation Protection. However, the electrical field strength on the roof adjacent to the high-voltage lines was significantly higher than that as measured on the other floors in the same buildings ( p < 0.05). The electromagnetic radiation measurements of different monitoring points, under the same high-voltage lines, showed the location which is nearer the high-voltage line maintain a consistently higher level of radiation than the more distant locations ( p < 0.05). Electromagnetic radiation generated by high-voltage lines decreases proportionally to the distance from the lines. The buildings can to some extent shield (or absorb) the electric fields generated by high-voltage lines nearby. The electromagnetic radiation intensity near high-voltage lines may be mitigated or intensified by the manner in which the high-voltage lines are set up, and it merits attention for the potential impact on human health. [ABSTRACT FROM AUTHOR]

Abstract: The NWW-striking Qinling Orogen formed in the Triassic by collision between the North China and Yangtze Cratons. Triassic granitoid intrusions, mostly middle- to high-K, calc-alkaline, are widespread in this orogen, but contemporaneous intrusions are rare in the southern margin of the North China Craton, an area commonly considered as the hinterland belt of the orogen. In this paper, we report zircon U–Pb ages, elemental geochemistry, and Sr–Nd–Hf isotope data for the Laoniushan granitoid complex that was emplaced in the southern margin of the North China Craton. Zircon U–Pb dating shows that the complex was emplaced in the late Triassic (228±1 to 215±4Ma), indicating that it is part of the post-collisional magmatism in the Qinling Orogen. The complex consists of, from early to late, biotite monzogranite, quartz diorite, quartz monzonite, and hornblende monzonite, which span a wide compositional range, e.g., SiO2 =55.9–70.6wt.%, K2O+Na2O=6.6–10.2wt.%, and Mg# of 24 to 54. The biotite monzogranite has high Al2O3 (15.5–17.4wt.%), Sr (396–1398ppm) and Ba (1284–3993ppm) contents and relatively high La/Yb (mostly 14–30) and Sr/Y (mostly 40–97) ratios, but low Yb (mostly 1.3–1.6ppm) and Y (mostly14–19ppm) contents, features typical of adakitic rocks. The quartz monzonite, hornblende monzonite and quartz diorite have a shoshonitic affinity, with K2O up to 5.58wt.% and K2O/Na2O ratios averaging 1.4. The rocks are characterized by strong LREE/HREE fractionation in chondrite-normalized REE pattern, without obvious Eu anomalies, and show enrichment in large ion lithophile elements but depletion in high field strength elements (Nb, Ta, Ti). The biotite monzogranite (228Ma) has initial 87Sr/86Sr ratios of 0.7061 to 0.7067, ε Nd(t) values of −9.2 to −12.6, and εHf(t) values of −9.0 to −15.1; whereas the shoshonitic granitoids (mainly 217–215Ma) have similar initial 87Sr/86Sr ratios (0.7065 to 0.7075) but more radiogenic ε Nd(t) (−12.4 to −17.0) and εHf(t) (−14.1 to −17.0). The Sr–Nd–Hf isotope data indicate that the rocks were likely generated by partial melting of an ancient lower continental crust with heterogeneous compositions, as partly confirmed by the widespread presence of early Paleoproterozoic inherited zircons. Mafic microgranular enclaves (MMEs), characterized by fine-grained igneous textures and an abundance of acicular apatites, are common in the Laoniushan complex. Compared with the host rocks, they have lower SiO2 (48.6–53.7wt.%) and higher Mg# (51–56), Cr (122–393ppm), and Ni (24–79ppm), but equivalent Sr–Nd isotope compositions, indicating that the MMEs likely originated from an ancient enriched lithospheric mantle. The abundance of MMEs in the granitoid intrusions suggest that magma mixing plays an important role in the generation of the Laoniushan complex. Collectively, it is suggested that the Laoniushan complex was a product of post-collisional magmatism related to lithospheric extension following slab break-off. Formation of the adakitic and shoshonitic intrusions in the Laoniushan complex indicates that the Qinling Orogen had evolved into a post-collisional setting by about 230–210Ma. [Copyright &y& Elsevier]

The impact of quaternary glaciation in eastern China on local fanua and flora has been a topic of considerable interest. We used mitochondrial DNA (mtDNA) sequence data and coalescent simulations to test two general biogeographic hypothesis related to the effects of Pleistocene climatic fluctuations for a widespread ophidian species ( Gloydius brevicaudus) in eastern China and Korean Peninsula. The phylogenetic analysis revealed three major lineages, the southeast Coastal, Yangtze and North Lineages. The latter two are closely related and jointly form a continental lineage. Divergence dating and coalescent simulations indicate a Late Pliocene to Early Pleistocene divergence between lineages from the southeast coast and continental interior, followed by a mid-to-late Pleistocene divergence between lineages from the north and the middle-lower Yangtze Valley across East China, suggesting that all these lineages predated the last glacial maximum. An overlapping range between the two lineages within the continental lineage and a secondary contact associated with ecological transition zones on the margins of the North China Plain were also observed. These results show that vicariance patterns dominated the history of G. brevicaudus. Though the climatic events of the Pleistocene have had a marked effect on the historical distribution and intra-specific divergence of reptiles in China, coalescent and non-coalescent demographic analyses indicate that all lineages of G. brevicaudus seem not to have been adversely affected by glacial cycles during the Late Pleistocene, presumably because of an increase in the amount of climatically mild habitat in East Asia due to a decline in elevation and the development of monsoons since the Mid-End Pleistocene. [ABSTRACT FROM AUTHOR]

Preserving many kinds of rice resources and rich variations, Guizhou Province is one of the districts with the highest genetic diversity of cultivated rice (Oryza sativa L.) in China. In the current research, genetic diversity and structure of 537 accessions of cultivated rice from Guizhou were studied using 36 microsatellite markers and 39 phenotypic characters. The results showed that the model-based genetic structure was the same as genetic-distance-based one using SSRs but somewhat different from the documented classification (mainly based on phenotype) of two subspecies. The accessions being classified into indica by phenotype but japonica by genetic structure were much more than that being classified into japonica by phenotype but indica by genetic structure. Like Ding Ying's taxonomic system of cultivated rice, the subspecific differentiation was the most distinct differentiation within cultivated rice. But the differentiation within indica or japonica population was different: japonica presented clearer differentiation between soil-watery ecotypes than indica, and indica presented clearer differentiation between seasonal ecotypes than japonica. Cultivated rices in Guizhou revealed high genetic diversity at both DNA and phenotypic levels. Possessing the highest genetic diversity and all the necessary conditions as a center of genetic diversity, region Southwestern of Guizhou was .,suggested as the center of genetic diversity of O. sativa L. from Guizhou. [ABSTRACT FROM AUTHOR]

• The Tieshan complex was emplaced at the time interval of 144 ± 1 to 135 ± 3Ma. • The Fe-Cu-related suite has geochemical signatures similar to typical high Ba-Sr granitoids. • Both the Fe-Cu related suite and Fe-related suite were primarily originated from the enriched lithospheric mantle. • The Fe-related suite has more contributions from continental crust compared with the Fe-Cu-related suite. • Oxygen fugacity and differentiation degree of magma are useful indicators for Fe and Cu skarn mineralization. Fe and Cu skarn deposits constitute the most important skarn type worldwide, whereas the controlling factors that lead to the difference in metal associations remain not well known. The Fe- and Cu-hosting Tieshan complex in the Edong district provides a good opportunity for comparative study on the genetic differences between Fe and Cu skarn deposits. In this study, integrated studies of geochronology, geochemistry and Sr-Nd-Hf isotope compositions were conducted on the complex. LA-ICP-MS zircon U-Pb dating results show that the Tieshan complex was emplaced in the time interval of 135 ± 3 to 144 ± 1 Ma. Multiphase rocks from the complex can be broadly subdivided into two suites. The Fe-Cu-related suite, which consists of diopside diorite, quartz diorite, quartz diorite porphyrite and porphyritic granodiorite, possesses low SiO 2 (53.5–67.1 wt.%), K 2 O (2.44–3.53 wt.%) and Rb (45−83 ppm) contents, but high Sr (1132−2684 ppm), Ba (1073−1656 ppm) contents and negligible Eu anomalies, with very high Sr/Y (>90) ratios, similar to typical high Ba-Sr granitoids. The rock suite has initial 87Sr/86Sr values of 0.70648 to 0.70737, ε Nd (t) values of −12.3 to −8.2 and ε Hf (t) values of −16 to −7, comparable to values of the Early Cretaceous mafic rocks in the Edong district and adjacent areas, indicating that it might be largely derived from an enriched lithospheric mantle source, along with minor involvement of lower-crustal components. By contrast, the Fe-related suite, which is composed of quartz diorite, quartz diorite porphyrite and granodiorite porphyry, is characterized by relatively high SiO 2 (63.0–71.0 wt.%) and K 2 O contents (3.36–5.53 wt.%), and a wide range of Sr (158−1135 ppm), Ba (762−1366 ppm) contents and Sr/Y (11–99) ratios. In combination with the presence of abundant inherited zircon grains, the lower ε Nd (t) (−12.4 to −9.3) and ε Hf (t) (−25 to −15) values indicate a greater degree of lower-crustal contribution for the Fe-related suite. In addition, the calculated zircon Ce (Ce/Ce* and Ce4+/Ce3+) and Eu (Eu/Eu*) anomalies suggest that the Fe-Cu-related suite has much higher oxygen fugacity (f O 2) than the Fe-related suite. This study highlights f O 2 and fractionation degree of magma as useful indicators for differentiating Fe and Cu skarn mineralization. [ABSTRACT FROM AUTHOR]

This paper proposes a novel cooperative game network DEA model for evaluating marine circular economy (MCE) performance. The proposed model considers the bidirectional link between the economic production (EP) and environmental treatment (ET) subsystems within the MCE system. Then, the cooperative game strategy between subsystems is modeled by maximizing the factor inefficiency both of subsystems into the model's measurement from a centralized control perspective. The evaluation results of China's regional MCE performances over 2006–2015 show that while most coastal areas have a better efficiency score for the EP system, their performance of the ET system is worse and leads to poor MCE performances. In addition, converge analysis indicates that there exists β converge of efficiency difference across coastal regions in the long term. Furthermore, the efficiency decomposition reveals that many inefficient environmental treatment inputs contribute to the worse performance of the ET system. Based on the above findings, several specific policy implications for the existing problems are provided to promote China's MCE. • A novel two-stage game DEA is proposed for evaluating MCE performance. • Regional disparity and stage characteristic of MCE in China are explored. • Convergence analysis of efficiency change are provided. • Factor efficiency is given as the determinant of system performance. • Policy suggestions are proposed for promoting marine circular economy. [ABSTRACT FROM AUTHOR]

Energy and carbon emission performance evaluation is a focus topic in the field of environmental protection and energy utilization. However, the current studies are not high in identifying economic output inefficiency and neglect to control target energy carbon emission intensity (ECI), which may cause evaluation bias. Hence, this paper presents a constrained performance index measure (CPIM) model to solve the issues. The proposed model takes the performance index measure and can identify more numbers of positive economic output inefficiency compared to the directional distance function (DDF) model. Besides, the ECI constraint is presented and imposed into the proposed model to restrict the target ECI of decision making units. The numerical example from China's provincial dataset demonstrates and confirms the validity and merit of the proposed model through the measure and constraint comparison among different models. Then, it is found that most provinces exist certain economic output inefficiency and the center regions have a worst score of energy carbon emission performance index due to the rapid development of their secondary industry by using the proposed model. Several valuable modeling directions and questions related to performance index measure and energy pollution emission constraints are provided for future research. • We propose a constrained performance index measure (CPIM) model. • The CPIM model can identify more economic output inefficiency than the DDF model. • The CPIM model can restrict target energy carbon emission intensity of DMUs. • The numerical example demonstrates the usefulness of the proposed approach. [ABSTRACT FROM AUTHOR]

This study evaluated the relationship between urine mercury (UHg) concentrations and renal function (serum creatinine (SCr) and blood urea nitrogen (BUN)) in delivery women in the Wanshan mercury (Hg) mining area. Leishan County was selected as the control area. 165 and 65 maternal samples were collected from the Wanshan and Leishan area, respectively. The geometric means of UHg concentrations were 1.09 and 0.29 μg/L in Wanshan and Leishan subjects, respectively. Significant differences (p < 0.01) of UHg were observed between the two populations, indicating the potential risks of inorganic Hg exposure in the Wanshan population. The median (interquartile range) values of SCr were 69.1 (12.5) μmol/L and 46.0 (11.0) μmol/L for the Wanshan and Leishan populations, respectively, indicating significant differences (p < 0.01) between the two groups. However, no significant differences among BUN values for the two groups were observed. A significant positive correlation (r = 0.385, p < 0.001) was observed between UHg concentration and SCr in the study population. The odds ratio (OR) value of UHg in Wanshan area was 9.29 times higher than that in Leishan area (95% confidence interval (CI): 3.58–24.1). The OR value of SCr decrease in patients with low UHg was 0.32 times higher than that in patients with high UHg (95% CI: 0.19–0.55). The OR value of SCr decrease in the population with fish consumption was 0.71 times higher than that of the population without fish consumption (95% CI: 0.58–0.88). In conclusion, maternal IHg exposure caused impaired renal function and fish consumption may play a role in preventing Hg-induced nephrotoxicity. • Effects of IHg exposure on renal function in delivery women was evaluated. • Significant elevation of UHg in the Wanshan population than control group. • A significant positive correlation was observed between UHg and SCr. • Maternal IHg exposure caused impairment of renal function. [ABSTRACT FROM AUTHOR]

Common bean (Phaseolus vulgaris L.) is a major legume and is frequently attacked by fungal pathogens, including Fusarium solani f. sp. phaseoli (FSP), which cause Fusarium root rot. FSP substantially reduces common bean yields across the world, including China, but little is known about how common bean plants defend themselves against this fungal pathogen. In the current study, we combined next-generation RNA sequencing and metabolomics techniques to investigate the changes in gene expression and metabolomic processes in common bean infected with FSP. There were 29,722 differentially regulated genes and 300 differentially regulated metabolites between control and infected plants. The combined omics approach revealed that FSP is perceived by PAMP-triggered immunity and effector-triggered immunity. Infected seedlings showed that common bean responded by cell wall modification, ROS generation, and a synergistic hormone-driven defense response. Further analysis showed that FSP induced energy metabolism, nitrogen mobilization, accumulation of sugars, and arginine and proline metabolism. Importantly, metabolic pathways were most significantly enriched, which resulted in increased levels of metabolites that were involved in the plant defense response. A correspondence between the transcript pattern and metabolite profile was observed in the discussed pathways. The combined omics approach enhances our understanding of the less explored pathosystem and will provide clues for the development of common bean cultivars' resistant to FSP. [ABSTRACT FROM AUTHOR]

[Display omitted] • Private debt can affect MSW from output efficiency of debt and debt effect. • The output efficiency of debt promotes decoupling and its role increases. • Generation intensity effect was the dominant factor for MSW generation. • MSW classification policy as a long-term measure can greatly improve decoupling. • Negative population growth will worsen decoupling while inhibiting MSW growth. As one type of debt 'borrowed' from nature, municipal solid waste (MSW) can be influenced by financing debt. Taking China as an example, an improved Logarithmic Mean Divisia Index (LMDI) model, together with the Tapio decoupling model, is developed to analyze the impact of private debt on MSW generation and the relationship between MSW and economic growth. The results show that the debt-income ratio promotes MSW generation and the output efficiency of debt inhibits MSW generation. Second, the linkage relationship between GDP growth and MSW shows three states: strong decoupling, expansion coupling and weak decoupling. The MSW generation per unit of GDP and the output efficiency of debt are the main contributors to the change of decoupling state. Third, implementing a MSW classification measure can greatly reduce the quantity of MSW removed and transported and improve the decoupling state. By 2035, deleveraging scenario and economic growth slowdown scenario can reduce MSW removal and transportation quantities by 765 and 1080 million tons, respectively. It is worth noting that negative population growth worsens decoupling while curbing MSW. The results provide a new perspective for the realization of MSW reduction and some sound policies are formulated to improve MSW management. [ABSTRACT FROM AUTHOR]

The sleep quality of patients with osteosarcoma (OS) was poorly understood. We aimed to evaluate the prevalence of sleep dysfunction in adolescent patients with OS using the Pittsburgh Sleep Quality Index (PSQI) and to further investigate the psychometric properties of the PSQI in this cohort of patients. Fifty four adolescent patients with OS who underwent chemotherapy treatment in our clinic centre were included. Sleep quality was assessed with the Chinese PSQI. Cronbach's alpha was calculated to evaluate the internal consistency. The confirmatory factor analysis (CFA) was used to determine the fitness of a two‐factor structure. Sleep disturbance was observed in 57.4% (31/54) of the patients. Patients with the presence of metastasis or more than 2 cycles of chemotherapy were found to have remarkably higher median global score. The overall Cronbach's alpha was 0.87. The CFA showed an overall comparative fit index of 0.97, a root mean square error of approximation of 0.06 and a standardised root mean square residual of 0.07 respectively. PSQI was a reliable instrument to evaluate the sleep quality of adolescent patients with OS. Over half of the patients may experience sleep disturbance during the treatment. Early psychological interventions were recommended to improve the sleep quality of the patients. [ABSTRACT FROM AUTHOR]

By core physical property, casting slice, scanning electron microscope analysis with energy disperse spectroscopy, the densification process of Chang 82 ultra-low permeability sandstone, Gufengzhuang-Mahuangshan area was studied. The study showed that there were four diagenetic events during densification process of the sandstone, which were calcite cement and compaction of early diagenesis stage A, chlorite film cement of early diagenesis stage B, and feldspar dissolution of middle diagenesis stage A on the basis of diagenetic sequence. By quantitative calculation, the initial porosity and permeability of sandstone in the area were 39.7% and 50 500×10-3 μm2 respectively. ln the course of early diagenesis stage A, both calcite cement and mechanical compaction caused the sandstone to very low permeability reservoir whose porosity and permeability were 12.1% and 1.07 ×10-3 μm2 separately. Then chlorite film in early diagenesis stage B converted very low permeability reservoir into ultra-low permeability reservoir whose porosity and permeability were 10.8% and 0.64×10-3 μm2 apart. During hydrocarbon accumulation in middle diagenesis stage A, feldspar dissolution formed secondary pore, authigenic quartz and kaolinite cement whose comprehensive effect made porosity and permeability up to 12.4% and 1.20×10-3 μm2 individually. So the densification process of Chang 82 ultra-low permeability sandstone, Gufengzhuang-Mahuangshan area is first densification then accumulation and accumulation with increasing porosity and permeability. [ABSTRACT FROM AUTHOR]