Search

Association between fasting serum glucose (FSG) and certain mineral elements has been extensively reported. Investigation regarding multi-element exposure among subjects with different exposure level is warranted to confirm the association and further explore dose-dependent relationship. A total of 3488 participants were recruited from four counties of Hunan province, South China. Basic characteristics were collected by face to face interview and 23 elements in plasma were determined by inductively coupled plasma mass spectrometry. We applied fully adjusted generalized linear regression model and multivariable restricted cubic spline function to test the association and dose-response relationship of FSG with 23 elements. The results indicated that FSG was positively associated with plasma78selenium level [regression coefficient (β), 0.001; 95 % confidence interval (CI), 0.001, 0.001] in a dose-dependent manner, robust to the adjustment for suspected covariates and stratification by age, gender, BMI and smoking status. A negative association was found between FSG and plasma 208lead (β, -0.004; 95 % CI, -0.016, -0.002), 52chromium (β, -0.002; 95 % CI, -0.004, -0.001) and 47titanium (β, -0.001; 95 % CI, -0.002, -0.001). 78selenium was positively while 208lead, 52chromium and 47titanium were negatively associated with FSG in the present study. However, prospective studies are needed to confirm the results. [ABSTRACT FROM AUTHOR]

Increasing evidence indicates the adverse effect of air pollution exposure during pregnancy on neurologic development among children. However, the impact on neurobehavioral development in fetus remains unknown. In 2017, a total of 1193 mother-newborns pairs were enrolled in a birth cohort study in Changsha, China. Exposures to PM 2.5 , PM 10, SO 2 , CO and NO 2 were determined by using inverse distance weighted method based on local monitoring station data. Neurobehavioral measure was administered at 48-72 h postpartum by utilizing the neonatal behavioral neurological assessment (NBNA). Basic information and covariates were collected by face to face interview. Generalized linear regression and multivariable restricted cubic spline function were performed to explore the trimester-specific association and dose-response relationship of maternal air pollution exposure with NBNA score, respectively. In adjusted three-pollutant model, PM 2.5 exposure in trimester 2 was negatively associated with behavior score (β, -0.003; 95% CI, -0.006, -0.001) and the inverse relation was more pronounced in male infants. In addition, PM 2.5 level in the 2nd trimester was negatively related to activetone score (β, -0.012; 95% CI, -0.021, -0.002) in a dose-dependent manner for both genders. Collectively, our results demonstrated that prenatal exposure to PM 2.5 was linked to poor neurobehavioral performance of newborns. The second trimester was the most sensitive time window for the developments of behavior and activetone, and male subject was more vulnerable as compared to females., (Copyright © 2020 Elsevier Ltd. All rights reserved.)