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Many research studies have shown that lower-secondary school students' scientific literacy depends on their understanding of corresponding scientific concepts. Therefore, it is of great significance to model and assess students' conceptual understanding in learning specific scientific concepts, because it can reflect and diagnose students' cognitive characteristics, so as to provide evidence for targeted educational interventions. However, on the topic of Moon Phases, existing research studies have deficiencies in the evaluation and analysis of different levels of students' conceptual understanding, which restrict teachers to take effective educational interventions to help them. Thus, this study explored a new level division and an assessment test for revealing and explaining students' different conceptual understanding in learning Moon Phases. This study was conducted among 768 Chinese lower-secondary school students. Through a variety of quantitative and qualitative analyses, it was found that students' conceptual understanding of Moon Phases can be divided into three levels of continuous improvement, including the mechanical memory of different phenomena of moon phases, the formation of a preliminary mental model of Moon Phases, and the construction of a complete mental model of Moon Phases. Accordingly, this study made some precise suggestions for effectively improving students' conceptual understanding of Moon Phases.

In Mainland China, the sports training process of most players is highly homogenized, the convergence of which makes them ineffectively be identified with their individual and specific profile and difficult for them to play the sports according to their strengths and characteristics. Moreover, existing sports training software does not differentiate between player types to provide customized persona. Therefore, efficient and personalized methods need to be provided to guide players towards more autonomous sports training. Current research shows that gamification design in the process of sports training can transform players' unique conscious behaviors into habits, thus increasing their autonomy. However, the current gamification design in sports training is only based on uniform gamification elements and does not take into account the player's motivation and gamification experience, which is one of the main reasons for the homogenization of sports training. Therefore, this study aimed to identify factors that contribute to the design of gamification systems in the field of sports training, as well as to determine the relationship between players' gamification experiences during sport. It will help the researchers to explore in depth the possibilities of learning environments for youth basketball training with the development of gamified experiences. This design-driven study performed both offline and online questionnaire research (N = 198), which was analyzed with the method of a 7-point Likert scale as well as the assistance of SPSS, identified potential for the establishment of a framework for analysing preferences for gamification design elements in the context of basketball training for young players. Based on the results, this paper finds that there is a correlation between immersion and achievement in gamification experiences and proposes a framework for gamification system design in the field of sports training and offers insight that may enable the development of gamification designs that can motivate players.

Effective teaching of STEM has become a significant concern for teachers' professional development (PD). Many teachers are not familiar with STEM strategies and do not possess the disciplinary knowledge or pedagogical strategies demanded by STEM teaching. The purpose of the study reported in this paper was to explore the path and model of Chinese teachers' professional development about STEM understanding based on their participation in the Zhejiang-Indiana STEM summer programme. This programme capitalises on strategies referred to as the "observation-discussion-reflection" (ODR) framework. The participants were 82 teachers who specialise in science, technology, or mathematics and who attended the training activities. There were two weeks of training interventions. Statistical analysis of two groups of teachers' pre-test and post-test, as well as the comparative analysis of two groups, were conducted. The changes in teachers' STEM discipline knowledge as well as their abilities and attitudes were investigated. Overall, the findings indicate variations in how teachers understand the different components of STEM knowledge with integrated knowledge requiring the most attention for further professional development.

Purpose: To explore care requirements of older adults with urinary incontinence (UI) and contributing factors. Method: This cross-sectional study used the Older Adults Urinary Incontinence Care Needs Inventory to survey participants with UI in three large-scale tertiary hospitals located in Guangzhou City, China, from January 2023 to November 2023. Statistical analyses, including analysis of variance, t tests, correlation analyses, and linear regression models, were conducted to assess factors influencing participants' care needs. Results: A total of 530 older adults with UI participated in the survey and mean standardized score for overall care needs was 78.65 (SD = 5.01), with mean scores for each dimension ranging from 70.88 (SD = 10.55) for social participation needs to 82.45 (SD = 7.11) for health education needs. Factors that were found to influence incontinence care needs in older adults included age, literacy level, number of leaks, and type of disease (F = 37.07, adjusted R2 = 0.290, p < 0.001). Conclusion: Comprehensive care for older adults with UI, encompassing physiological, psychological, and social aspects, is crucial. It is essential to tailor care to individual needs and characteristics, taking into account factors, such as age and education, to ensure effective care. [Journal of Gerontological Nursing, 50(5), 43–49.] [ABSTRACT FROM AUTHOR]

Species diversity can be underestimated due to a lack of regional studies and limitations in research methods. China is widely recognized as one of the primary hotspots for the biodiversity of freshwater mussels as it harbours a wealth of endemic species. Pseudocuneopsis was recently established to belong to the Unioninae subfamily within Unionidae and is endemic to China. Recent research has expanded the diversity and range of distribution of this genus. However, sufficient data is required to precisely determine the phylogenetic relationships within Pseudocuneopsis. This study conducted an integrative taxonomy using morphological, COI barcode, and complete maternal mitogenome data to clarify the taxonomy of Pseudocuneopsis. Both morphological and COI barcode data supported the validity of all Pseudocuneopsis species. Furthermore, a new species, Pseudocuneopsis yemaoi sp. n. was described from a tributary of the Man River in Hubei, China. Mitochondrial phylogenomic analyses showed that P. yemaoi was closely related to P. sichuanensis and resolved phylogenetic relationship as (P. capitata + (P. yangshuoensis + (P. sichuanensis + P. yemaoi))). Our results highlight the significance of utilizing integrative classification methods. Moreover, we propose enhancing the research and preservation measures of minor streams in China, as these streams may house distinctive species. [ABSTRACT FROM AUTHOR]

Japanese apricot is an important subtropical deciduous fruit tree in China, widely distributed in different altitude areas. How does it adapt to the different temperature environments in these areas? In this study, we identified a low‐temperature transcription factor PmCBF03 on chromosome 7 through adaptive analysis of populations at different altitudes, which has an early termination single nucleotide polymorphism mutation. There were two different types of variation, PmCBF03A type in high‐altitude areas and PmCBF03T type in low‐altitude areas. PmCBF03A gene increased the survival rate, Fv/Fm values, antioxidant enzyme activity, and expression levels of antioxidant enzyme genes, and reducing electrolyte leakage and accumulation of reactive oxygen species in transgenic Arabidopsis under low temperature and freezing stress. Simultaneously, PmCBF03A gene promoted the dormancy of transgenic Arabidopsis seeds than wild‐type. Biochemical analysis demonstrated that PmCBF03A directly bound to the DRE/CRT element in the promoters of the PmCOR413, PmDAM6 and PmABI5 genes, promoting their transcription and enhanced the cold resistance and dormancy of the overexpressing PmCBF03A lines. While PmCBF03T gene is unable to bind to the promoters of PmDAM6 and PmABI5 genes, leading to early release of dormancy to adapt to the problem of insufficient chilling requirement in low‐altitude areas. Summary statement: The PmCBF03 allele variation is involved in regulating the low‐temperature adaptability of Japanese apricots at different altitudes. [ABSTRACT FROM AUTHOR]

Superficial weathering in the form of granular disaggregation, powdering and flaking on stone surface is one of the most serious damages to stone heritages, since the surface carries most of the artistic, historical information. The determination of the thickness of the superficially weathered layer of historical stones is critical to their conservation. However, the methodology for quantitative analyses of such thickness remains very limited. In this study, we carefully study the vapor absorption and pore structure evolution of historical sandstones from Guanzhong area with respect to their weathering. We find out that the thickness of superficial weathered layer of Guanzhong sandstones can be derived by following the changes in vapor absorption or pore structure. Such data achieved from various methods developed in this work are consistent with each other and in good agreement with the results obtained by using current techniques such as drilling resistance measurement, the Ruxton method and ultrasonic testing. Among all methods used, pore size distribution analysis requires less sample preparation and measures the thickness of superficial weathered layer of Guanzhong sandstones around 7 mm. [ABSTRACT FROM AUTHOR]

The present study explores ways to enhance students' question-asking ability (i.e., the ability to ask critical questions), which is the premise of scientific inquiry and a precondition for effective science teaching. A survey of junior high school students in Zhejiang province in China showed that students' questioning behavior was not well developed and that their ability and willingness to question authority were weak. These results are consistent with an educational culture that dictates that textbooks and science teachers are always correct and cannot be questioned. The intervention involved several designed cases that included the explicit teaching of questioning strategies and ample opportunities to ask questions for inquiry and question card use. After the intervention, a dependent t-test of several dimensions was conducted, the students' question-asking consciousness and question quality were compared, and the frequency distribution of different levels of questions was analyzed and compared. The development of question-asking ability was further identified in the interviews. The efficacy and implications of the treatment for enhancing the critical question-asking ability of middle-school students in Chinese science classrooms are discussed.

Urban Agglomeration (UA) is regarded as an emerging complex urban system in China. The development of UA demands a reasonable scale structure, which can be investigated by Zipf's law. However, few studies have been conducted to quantify the optimal scale of UA and how its development deviates from the optimal scale. With the continuous urban expansion, the problem of UAs' scale structure has received increasing attention. In this study, we propose a method based on Zipf's law for estimating the theoretical optimal scale of UAs in China and assessing the deviation rate from their optimal scales. Twelve typical UAs in China are selected, and their development is assessed via urban impervious surface data from 2000 to 2018. The results show that the average deviation rate of the investigated UAs decreased from 3.40% in 2000 to 2.32% in 2018, demonstrating that these UAs are on a positive evolution trajectory. Furthermore, according to the development stage, we make recommendations on "large cities vs. medium/small-sized cities and promoting vs. restraining" to each UA based on its size. The conceptual and analytical knowledge, as well as the results from this study, are expected to offer valuable insights and new references for regulating and managing UAs' development in China. [ABSTRACT FROM AUTHOR]

Several important processes in the petrogenesis of granite are still debated due to a poor understanding of complex interactions between minerals during the melting and melt segregation processes. To promote an improved understanding of the mineral-melt relationships, we present a systematic petrographic and geochemical analysis for melanosome and leucosome samples from the Triassic Jindong migmatite, South China. Petrographic observations and zircon U-Pb geochronology indicate that the Jindong migmatite was formed through water-fluxed melting of the Early Paleozoic gneissic granite (437 ± 2 Ma) during the Triassic (238 ± 1 Ma), with the production of melt dominated by the breakdown of K-feldspar, plagioclase, and quartz. The Jindong leucosomes may be divided into lenticular and net-structured types. Muscovite, plagioclase, and K-feldspar in the net-structured leucosome show higher Rb and much lower Ba and Sr contents than those in the lenticular leucosome. This may be attributed to the elevation of Rb and decreasing Ba and Sr abundances in melts during the segregation process due to early fractional crystallization of K-feldspar and plagioclase. These leucosomes show negative correlation between εNd(t) and P2O5, reflecting increasing dissolution of low-εNd(t) apatite during the melting process. The continuous dissolution of apatite caused saturation of monazite and xenotime in melt, resulting in the growth of monazite and xenotime around apatite in the melanosome. This process led to a sharp decrease of Th, Y, and REE with increasing P2O5 in the leucosome samples. This complex interplay of accessory mineral reactions in the source impacts REE geochemistry and Nd isotope ratios of granites. As the granites worldwide exhibit similar compositional and isotopic patterns to the Jindong leucosomes, we suggest that both the melting and melt segregation processes strongly control the granitic melt compositions. [ABSTRACT FROM AUTHOR]

Trace element compositions of magnetite of alkaline mafic–ultramafic rocks were not previously studied but are potentially useful to constrain their petrogenesis and related metallogenesis. In the Permian Emeishan large igneous province, subalkaline mafic–ultramafic intrusions are widely distributed, but sparse alkaline counterparts are recognized, including the Mouding intrusion. The alkaline intrusions are mainly composed of clinopyroxenite, melteigite, jacupirangite, gabbro, syenogabbro, monzogabbro and monzonite. All these lithologies contain magnetite with composite, sandwich and trellis types of ilmenite intergrowths due to heterogeneous oxy-exsolution. Chromium contents of magnetite grains in the magnetite clinopyroxenite unit of the Mouding intrusion decrease from 1257 to 41 ppm within an 80 m interval, which can best be explained by the diffusion-controlled in situ crystallization in a crystal-liquid framework. Notably, magnetite grains from these alkaline intrusions are rich in Nb, Ta, Zr and Hf relative to those from subalkaline intrusions and iron oxide–apatite (IOA), iron oxide copper gold (IOCG) and porphyry deposits. This enrichment demonstrates that the high field strength elements (HFSE) are rich in the parental magmas of alkaline intrusions and have high partition coefficients between magnetite and alkaline magma. Our study demonstrates that magnetite grains in alkaline mafic–ultramafic intrusions have distinctively different trace element compositions from those in subalkaline intrusions, being useful tools in discriminating magma series and understanding the crystallization processes. [ABSTRACT FROM AUTHOR]

Aim: Wuzhi preparations (WZP) are commonly administrated with tacrolimus (TAC) in China to improve the liver function and increase the exposure of TAC. This study aims to investigate the effects of WZP on TAC in pediatric heart transplantation (HTx) patients carrying the CYP3A5*1 allele during the early period after transplantation and also make a comparison with these effects in adult recipients. Methods: A total of 81 recipients with CYP3A5*1 allele were included and divided into the pediatric group (n = 29) and adult group (n = 52). The changes in TAC dose‐corrected trough blood concentrations (C0/D), dose requirement as well as intra‐patient variability(IPV) of C0/D after co‐therapy with WZP were evaluated. Results: The TAC C0/D was significantly increased 1.7 and 1.8 times after co‐administration of WZP in the pediatric and adult groups, respectively. We further analyzed the pediatric patients, found that no statistical difference was observed in TAC C0/D before and after co‐therapy with WZP in children <6 years old. The changes of C0/D increased with the dose of the active ingredient (Schisantherin A) in adult patients, but not in pediatric patients. TAC IPV was reduced by 10.5% in pediatric patients and 4.8% in adult patients when co‐administrated with WZP. Furthermore, after taking WZP, the AST and TB were dramatically lowered in pediatric recipients. Conclusion: Our study is the first attempt to demonstrate the effects of WZP on TAC in pediatric HTx recipients. By comparing these effects to those observed in adult recipients, valuable insights can be gained regarding the efficacy and potential benefits of WZP in the pediatric population. [ABSTRACT FROM AUTHOR]

Torreya grandis cv. Merrillii is an important economic tree widely cultivated in hilly subtropical areas in China and some parts of Japan and Korea. Crown and root rot was found on T. grandis in Zhejiang Province of China. Three isolates with similar morphology were isolated from diseased samples, and used for identification and pathogenicity tests. The pathogenicity of the isolates was confirmed by fulfilling Koch's postulates. The pathogen was identified as Fusarium commune based on morphological characteristics and phylogenetic tree constructed by combining ITS and TEF‐1α gene sequences. This is the first report of F. commune causing crown and root rot on T. grandis in China. [ABSTRACT FROM AUTHOR]

Background: Implant-related infections are a challenging complication of orthopedic surgery, primarily due to the formation of bacterial biofilms on the implant surface. An antibacterial coating for titanium implants was developed to provide novel insights into the prevention and treatment of implant-related infections. Methods: Titanium plates were coated with TiO2 nanotubes by anodization, and iodine was doped onto the coating via electrophoretic deposition. The obtained plates were characterized using a range of analytical techniques. Subsequently, Staphylococcus aureus was inoculated onto the surfaces of untreated titanium plates (control group), TiO2-nanocoated titanium plates (TiO2 group), and iodine-doped TiO2-nanocoated titanium plates (I-TiO2 group) to compare their antibacterial properties. Results: Twenty-four hour in vitro antimicrobial activity test of the I-TiO2 group against Staphylococcus aureus was superior to those of the other groups, and this difference was statistically significant (P < 0.05). Conclusions: This coating technology provides a new theoretical basis for the development of anti-infective implants against Staphylococcus aureus in orthopedics. [ABSTRACT FROM AUTHOR]

As a group of ectoparasites, chiggers (larvae of chigger mites) are the exclusive vector of scrub typhus (tsutsugamushi disease). Rodents are the most important hosts of chiggers. The Anderson's niviventer rat, Niviventer andersoni, is an endemic species of rodent in China. However, few studies have involved this endemic rodent species and its ectoparasites including chiggers. According to the field investigation in five provincial regions of southwest China between 2001 and 2019, this paper retrospectively analysed the infestation and distribution of chiggers on the body surface of N. andersoni in southwest China for the first time. From 77 Anderson's niviventer rats captured, a total of 527 chiggers were collected and they were identified as 39 species and nine genera in two subfamilies of family Trombiculidae. Of 39 chigger species identified, Leptotrombidium deliense and L. scutellare are the most important vectors of scrub typhus in China. The overall infestation indexes were PM = 29.87%, MA = 6.84 and MI = 22.91, and the indexes of chigger mite community were Mf = 39, H' = 2.60, E = 0.71 and D = 0.12. The dominant chigger species are L. wenense, L. xiaguanense and L. fujianense with a total Cr = 51.04%, among which L. wenense is one of the six main vectors of scrub typhus in China. The dominant chigger species are of aggregated distribution among different individuals of the rats. [ABSTRACT FROM AUTHOR]

Ruizhongite (IMA2022-066), (Ag2o)Pb3Ge2S8, is a thiogermanate of economic importance discovered in the Wusihe Pb-Zn deposit in Sichuan Province, southwestern China. This mineral occurs as anhedral grains 1–10 μm in size. It is gray and opaque, with a metallic luster and black streak, closely associated with galena and pyrite in a sphalerite matrix. Under reflected light, it displays a greenish-gray color without internal reflection. Its reflectance values in air (R %) based on SiC as the reference material are 30.5, 32.2, 34, and 34.1 for corresponding wavelengths of 650, 589, 470, and 546 nm, respectively. According to the average of 18 electron microprobe analyses, Pb (57.37 wt%), S (21.39 wt%), Ge (11.53 wt%), Ag (7.34 wt%), Zn (1.57 wt%), and Fe (0.27 wt%) constitute 99.46 wt% of ruizhongite. The empirical formula based on the 8 S apfu is (Ag0.82Pb0.32Zn0.28Fe0.06)Σ1.48Pb3Ge1.9S8, and (Ag2o)Pb3Ge2S8 is its ideal formula. Ruizhongite displays a cubic structure, space group I43d (#220), with the unit-cell parameters a = 14.0559(2), V = 2777.00(7), Z = 8, and the calculated density is 5.706 g/cm3. The strongest powder X-ray diffraction lines [d in Å (I) (hkl)] are 3.755 (100) (123), 3.511 (76) (004), 2.992 (73) (233), 2.574 (21) (125), 2.482 (79) (044), 2.276 (46) (235), 1.784 (39) (237), and 2.075 (24) (136). The structure of ruizhongite was determined using single-crystal XRD and was refined to an R1 of 0.0323 for all 2594 (474 unique) reflections. The structure comprises a non-centrosymmetric arrangement of [GeS4]4− tetrahedra, forming two interstice sites: fully occupied Pb1 and partially occupied Ag1, aligned in the directions of a-, b-, and c-axes. Ruizhongite was named in honor of Ruizhong Hu (1958), an eminent Chinese ore geochemist. The discovery of ruizhongite has significant implications for the occurrence and enrichment mechanism of Ge in sphalerite and other metallic minerals. [ABSTRACT FROM AUTHOR]

The increase in non-point source (NPS) pollution from agricultural cultivation and production sources has been cited as one of the main reasons for water eutrophication. This study built a national NPS database and estimated the nutrient (including both nitrogen (N) and phosphorus (P)) balance and NPS pollution of crop farming at the county level in 2015. Finally, the NPS pollution risks were assessed, and relative policy suggestions were provided. The results indicated that (1) in 2015, the total amounts of N and P surpluses in China were 7.95 and 7.39 million tons, respectively. The south of the Yangtze River had a relatively higher nutrient surplus compared to that in northern China. (2) The NPS emissions for N and P in China were 168.84 × 104 tons and 8.93 × 104 tons, respectively, with the highest NPS loads occurring in the eastern part of the Sichuan Basin, southern China and southwestern China, while the lowest loads occurred in northeast China. (3) The potential risk assessment results showed that a broad division emerged at the Yangtze River basin, with the northern area under lower risk than the southern area. This estimation work can provide guidance and technical support for local government and policy makers to control NPS pollution. [ABSTRACT FROM AUTHOR]

Albinism is a kind of anomalous hypopigmentation with a complete white pelage, and it is completely devoid of melanin in the skin, hair follicles and eyes. The present paper firstly reports two cases of adult mole shrews (Anourosorex squamipes) with albinism, which were found in Sichuan province of southwestern China. The two female mole shrews show a complete white pelage. Stained by the soil, the albinistic mole shrews show a yellowish white color. Besides the same morphological characteristics, all the body parameters of the two albinistic mole shrews are within the parameter range of the six normal mole shrews captured at the same site. [ABSTRACT FROM AUTHOR]

A peak is an important topographic feature crucial in quantitative geomorphic feature analysis, digital geomorphological mapping, and other fields. Most peak extraction methods are based on the maximum elevation in a local area but ignore the morphological characteristics of the peak area. This paper proposes three indices based on the morphological characteristics of peaks and their spatial relationship with ridge lines: convexity mean index (CM-index), convexity standard deviation (CSD-index), and convexity imbalance index (CIB-index). We develop computation methods to extract peaks from digital elevation model (DEM). Subsequently, the initial peaks extracted by neighborhood statistics are classified using the proposed indices. The method is evaluated in the Qinghai Tibet Plateau and the Loess Plateau in China. An ASTER Global DEM (ASTGTM2 DEM) with a grid size of 30 m is chosen to assess the suitability of the proposed mountain peak extraction and classification method in different geomorphic regions. DEM data with grid sizes of 30 m and 5 m are used for the Loess Plateau. The mountain peak extraction and classification results obtained from the different resolution DEM are compared. The experimental results show that: (1) The CM-index and the CSDindex accurately reflect the concave or convex morphology of the surface and can be used as supplements to existing surface morphological indices. (2) The three indices can identify pseudo mountain peaks and classify the remaining peaks into single ridge peak (SR-Peak) and multiple ridge intersection peak (MRI-Peak). The visual inspection results show that the classification accuracy in the different study areas exceeds 75%. (3) The number of peaks is significantly higher for the 5 m DEM than for the 30 m DEM because more peaks can be detected at a finer resolution. [ABSTRACT FROM AUTHOR]

Based on the endogenous growth theory, this paper uses the Gini coefficient to measure educational inequality and studies the empirical relationship between educational inequality and income inequality through a simultaneous equation model. The results show that: (1) Income inequality leads to educational inequality while the reduction of educational equality does not contribute to the decrease of income inequality, and there is no simple casual effect between them. However education expansion is beneficial to reduce educational inequality and income inequality. (2) Education relates to income inequality through the human capital transmission mechanism, but this mechanism does not automatically translate into a virtuous cycle of "educational equality[double arrow]income equality". (3) In the long run, the reduction of educational inequality does not reduce income inequality, but income inequality has a negative instant-impact on educational equality. (4) At present, the level of educational investment and urbanization do not effectively promote educational equality. In addition, the robustness of the model used in this paper has been partly proved.

Background: There is currently a lack of a precise, concise, and practical clinical prediction model for predicting coronary artery disease (CAD) in patients with essential hypertension (EH). This study aimed to construct a nomogram to predict CAD in patients with EH based on flow-mediated dilation (FMD) of brachial artery and traditional risk factors. Methods: Clinical data of 1752 patients with EH were retrospectively collected. High-resolution vascular ultrasound was used to detect FMD in all patients at the Fujian Hypertension Research Institute, China. Patients were divided into two groups, i.e. training group (n = 1204, from August 2000 to December 2013) and validation group (n = 548, from January 2014 to May 2016) according to the time of enrollment. Independent predictors of CAD were analyzed by multivariable logistic regression in the training group, and a nomogram was constructed accordingly. Finally, we evaluated the discrimination, calibration, and clinical applicability of the model using the area under curve (AUC) of receiver operating characteristic analysis, calibration curve combined with Hosmer-Lemeshow test, and decision curve, respectively. Results: There were 263 (21.8%) cases of EH combined with CAD in the training group. Multivariate logistic regression showed that FMD, age, duration of EH, waist circumference, and diabetes mellitus were independent influencing factors for CAD in EH patients. Smoking which was close to statistical significance (P = 0.062) was also included in the regression model to increase the accuracy. Ultimately, the nomogram for predicting CAD in EH patients was constructed according to above predictors after proper transformation. The AUC values of the training group and the validation group were 0.799 (95%CI 0.770–0.829) and 0.836 (95%CI 0.787–0.886), respectively. Calibration curve and Hosmer-Lemeshow test showed that the model had good calibration (training group: χ2 = 0.55, P = 0.759; validation group: χ2 = 1.62, P = 0.446). The decision curve also verified the clinical applicability of the nomogram. Conclusion: The nomogram based on FMD and traditional risk factors (age, duration of EH disease, smoking, waist circumference and diabetes mellitus) can predict CAD high-risk group among patients with EH. [ABSTRACT FROM AUTHOR]

CU test and CD test were performed to capture the stress-strain characteristics of the clay in Dongting Lake area, China. Since the classical constitutive model cannot ideally describe the strain hardening behavior of the clay, an improved constitutive model that involved three damage factors was proposed. The damage first factor D 1 , which represents elemental volume strength F , was fitted by the Weibull function. The second and third damage factors D 2 and D 3 , which represent the porosity ratio e and the drainage rate P ε respectively, were fitted by Harris function. The CD test damage model is constructed by D 1 , D 2 , and D 3 . In the CU test, the porosity ratio e is a constant value, and the drainage volume is 0, so that D 2 is constant value and D 3 is 0. Therefore, the CU test damage model of the clay was constructed using the damage first factor D 1 . In the end, the accuracy of the proposed CU/CD damage constitutive models of the clay was validated with the experimental results. It is found that the results fitted by the proposed methodology are in good agreement with the experimental results. [ABSTRACT FROM AUTHOR]

The study was to analyze the fluctuation trend and influencing factors of unit price of soybean meal in China. Based on MSIH (3)~VAR (2) model, the monthly data from April 2014 to December 2020 were selected to analyze the fluctuation situation and influencing factors of domestic soybean meal raw material unit price from the perspective of nonlinear. The results showed that the overall unit price of soybean meal raw materials can be summarize as "market downturn-stable operation-unit price rise" three regional system characteristics. Further analysis of the factors affecting the unit price of soybean meal raw materials showed that the fluctuation of corn price would cause the price of soybean meal raw materials to fluctuate in the same direction, but with lagging characteristics in terms of demand. At the supply level, the fluctuation of soybean meal raw material price was affected by the changes of agricultural production price, output and agricultural production price in the same direction, and the effect was more severe in the period of soybean meal raw material price rising, and weaker in the period of soybean meal raw material price low and stable. The study indicates that the unit price of soybean meal raw materials is easily affected by multiple factors on the supply side and the demand side, the price fluctuation of soybean meal raw materials should be stabilized from the price of soybean substitutes and the price of soybean production. [ABSTRACT FROM AUTHOR]

Environmental assessments are important tasks for the long-term, sustainable development of cities. With the rapid urbanization in China, it is crucial to establish a City Sustainability Index (CSI) and evaluate the environmental conditions in major cities. However, most of the existing major sustainability indices/indicators are not able to assess cities at diverse levels of development using common axes of evaluation. In this work, we incorporate urban built-up areas extracted from high-resolution remote sensing images as indicators to measure the degree of urban development in city sustainability evaluation and propose a comprehensive index, i.e., the Urban Geographic Environment Index (UGEI). In order to eliminate the impact of urban development levels, UGEI mainly consists of area-averaged indices which are calculated from original indices and urban built-up areas. We adopt a comprehensive weighting method by using the analytic hierarchy process (AHP) method to weigh the high-level indicators and using the entropy weighting method to weigh low-level indicators. We evaluate the environmental conditions of 30 China's provincial capitals from the aspects of pressure, state, response, and overall status. In addition, we analyze how diverse types of indicators affect the values of UGEIs. The major findings are as follows: (1) About half of the provincial capitals in China have poor sustainability in environmental conditions, and more environmental protection measures should be taken in developing cities; (2) the environmental conditions of the provincial capitals in China present a four-region distribution pattern, namely, the northeastern coastal region, northwest inland region, southwest region, and southeast region; (3) and indices based on urban built-up extents can be common axes of evaluation for cities at diverse levels of development. The proposed UGEI can serve as an effective and reliable index for sustainability evaluation in environmental conditions. [ABSTRACT FROM AUTHOR]

Corn silk (Stigma maydis), being the styles and stigmas of maize, is a famous traditional medicine and functional tea in China. Research into the chemical composition of corn silk led to the identification of an unreported flavone (1, silkone A), accompanying with three known flavonoids (2–4). And their structures were elucidated through comprehensive spectroscopic analysis. Each obtained compound was evaluated for antioxidant capacity by DPPH, ABTS and FRAP assays. As a result, all tested compounds exhibited stronger radicals scavenging activities than Trolox in ABTS radical assay and displayed relatively weak antioxidant capacity in the other two experiments. Tyrosinase inhibitory activities of compounds 1–4 were also investigated, and compounds 3 and 4 demonstrated moderate inhibitory activities to tyrosinase with IC50 values of 0.49 and 0.21 mM, respectively, which was further investigated through molecular docking calculation. These results may contribute to the development of novel antioxidants and tyrosinase inhibitors from corn silk. [ABSTRACT FROM AUTHOR]

Based on the field investigation in five provincial regions of Southwest China between 2001 and 2019, the present paper reports the infestation and distribution of chigger mites on the Confucian white-bellied rat Niviventer confucianus in China for the first time. A total of 11,017 chigger mites were collected from the body surface of 911 N. confucianus rat hosts, and 10,161 of them were identified as 166 species and 16 genera in three subfamilies under two families with high species diversity (S = 166, H' = 3.19, E = 0.62). Of 911 N. confucianus rats, 341 individuals were infested with chiggers with high overall prevalence (PM = 37.43%), mean abundance (MA = 12.09 mites/rat) and mean intensity (MI = 32.31 mites/rat). On the body surface of N. confucianus, Ascoschoengastia sifanga was the most dominant chigger species followed by Walchia ewingi and Leptotrombidium rupestre. All the three dominant chigger species showed an aggregated distribution pattern among different individuals of N. confucianus. Chigger infestations on the same rat host (N. confucianus) showed some heterogeneity under different environmental conditions such as latitudes, longitudes, altitudes and landscapes. Based on Preston's lognormal model, the species abundance distribution of chiggers on N. confucianus conformed to a lognormal distribution pattern, and the predicted total species of chiggers on N. confucianus in Southwest China was estimated to be 228 species. [ABSTRACT FROM AUTHOR]

Background: The emergence of multidrug resistance among enterococci makes effective treatment of enterococcal infections more challenging. Giant pandas (Ailuropoda melanoleuca) are vulnerable to oral trauma and lesions as they feast on bamboo. Enterococci may contaminate such oral lesions and cause infection necessitating treatment with antibiotics. However, few studies have focused on the virulence and drug resistance of oral-derived enterococci, including Enterococcus faecium, in giant pandas. In this study, we analyzed the prevalence of 8 virulence genes and 14 drug resistance genes in E. faecium isolates isolated from saliva samples of giant pandas held in captivity in China and examined the antimicrobial drug susceptibility patterns of the E. faecium isolates. Results: Twenty-eight isolates of E. faecium were successfully isolated from the saliva samples. Four virulence genes were detected, with the acm gene showing the highest prevalence (89%). The cylA, cpd, esp, and hyl genes were not detected. The isolated E. faecium isolates possessed strong resistance to a variety of drugs; however, they were sensitive to high concentrations of aminoglycosides. The resistance rates to vancomycin, linezolid, and nitrofurantoin were higher than those previously revealed by similar studies in China and other countries. Conclusions: The findings of the present study indicate the drugs of choice for treatment of oral E. faecium infection in the giant panda. [ABSTRACT FROM AUTHOR]

Introduction: Myopia is an increasingly serious health problem in China. The aim of this study was to investigate the prevalence of myopia and the factors associated with it among students in Nantong, China, to show the current status of myopia prevention. Methods: This school-based, cross-sectional study examined students from all high schools in an urban area of Nantong, China. At least two classes were randomly selected from each grade of each school. A self-reported questionnaire was used to collect the required information. Univariate analyses were performed to identify associations between myopia and various parameters. Noncycloplegic autorefraction and visual acuity were assessed for each student. Factors that were statistically significant in univariate analyses were selected for multivariate analyses. Myopia was defined as a spherical equivalent refraction of ≤−0.5 diopters. Results: The completion percentage of students out of the whole high school was 6.5%. The overall prevalence of myopia was 94%. The response percentage of the number of validated questionnaires was 90.2%, of which 50.2% (n = 1,466) were from male participants, and 49.8% (n = 1,452) were from female participants. The mean (SD) of age was 15.22 ± 1.75 years, ranging from 12 to 18 years. Factors such as female sex, older age, parental myopia, sitting in the back of the classroom, increased homework time, and minimal outdoor activity were significantly associated with a higher risk of myopia (p < 0.05). In the myopic population, most students (67.9%) did not take measures to prevent further progression of myopia. Conclusion: The prevalence of myopia among high school students was 94%. Female sex, older age, parental myopia, sitting in the back of the classroom, increased homework time, and minimal outdoor activity were significantly associated with a higher risk of myopia. Most students with myopia (67.9%) did not take measures to prevent further progression of myopia. [ABSTRACT FROM AUTHOR]

As the main carbon sink in the carbon cycle process, vegetation is an important support for achieving "carbon peaking" and "carbon neutrality. How does the vegetation coverage of urban built-up areas change in the process of urbanization in China? Taking advantage of Landsat remote sensing data, we extract urban built-up areas, calculate the Normalized Difference Vegetation Index (NDVI), estimate fractional vegetation cover (FVC), and analyze the temporal and spatial dynamics of vegetation coverage in built-up areas of provincial capitals from the national and individual city levels in China. Major conclusions are as follows: (1) The FVC in the urban built-up areas has increased by 7.97%, and the urban green space has gradually changed from the "green core" distribution model to the "green vein" distribution mode. (2) The disparities in FVC of built-up areas of provincial capitals are notable, presumably due to a variety of factors that include the natural geographic environment, economic development level, built-up area expansion, land type conversion, afforestation of greening policy, etc. (3) Not just simply raise or lower, the FVC curves in the built-up areas of provincial capital cities present oscillating patterns with gradually weakening amplitude. Our study is expected to provide scientific references of an important theoretical basis for urban ecological construction and practical support for promoting the harmonious development of urban residents and urban environments in China. [ABSTRACT FROM AUTHOR]

It remains challenging to control Tomicus spp., a pest with fast spreading capability, leading to the death of large numbers of Pinus yunnanensis (Franch.) and posing a severe threat to ecological security in southwest China. Therefore, it is crucial to effectively and accurately monitor the damage degree for Pinus yunnanensis attacked by Tomicus spp. at large geographical scales. Airborne hyperspectral remote sensing is an effective, accurate means to detect forest pests and diseases. In this study, we propose an innovative and precise classification framework to monitor the damage degree of Pinus yunnanensis infected by Tomicus spp. using hyperspectral UAV (unmanned aerial vehicle) imagery with machine learning algorithms. First, we revealed the hyperspectral characteristics of Pinus yunnanensis from a UAV-based hyperspectral platform. We obtained 22 vegetation indices (VIs), 4 principal components, and 16 continuous wavelet transform (CWT) features as the damage degree sensitive features. We classified the damage degree of Pinus yunnanensis canopies infected by Tomicus spp. via three methods, i.e., discriminant analysis (DA), support vector machine (SVM), and backpropagation (BP) neural network. The results showed that the damage degree detected from the BP neural network, combined with 16 CWT features, achieved the best performance (training accuracy: 94.05%; validation accuracy: 94.44%). [ABSTRACT FROM AUTHOR]

Strengthening environmental regulation (Reg) is an important measure to solve energy and environmental problems, then to realize the profit sustainable growth (Gro). Taking 116 listed renewable energy enterprises in China from 2010 to 2019 as samples, this paper uses FE and SYS-GMM models to examine the moderating effect of three types of Reg in the relationship of factor market distortions (Dist) and the Gro. The conclusions are as follows: For the direct impact, capital and labor market distortions (DistK and DistL) hinder the Gro. Specifically, the absolute value of the coefficient of DistK in state-owned enterprises (SOEs) is greater than that of the DistL, which indicates that the inhibitory effect of DistK in SOEs is more significant. For the indirect impact, the coefficients of economic and supervised environmental regulation (RegE and RegS) are positive and significant, and promote the Gro of SOEs and non-SOEs, while legal environmental regulation (RegL) is the opposite, which shows that Reg has significant "cost effect" and "rebound effect". Moreover, Reg has a positive moderating effect, which is mainly reflected in SOEs, and alleviates the inhibitory effect of DistK and DistL on Gro to a certain extent. Finally, this paper puts forward some targeted policy suggestions. [ABSTRACT FROM AUTHOR]

Introduction: Adult acute myeloid leukaemia (AML) patients with complex karyotype (CK) generally have unfavourable outcomes. CK commonly co‐exists with characteristic chromosomal and genetic abnormalities such as monosomal karyotype (MK), −17 or 17p‐ [abn(17p)] and TP53 mutations. Their individual prognostic significance needs to be clarified. Methods: Seventy‐three adult CK‐AML patients and eleven adult non‐CK‐AML patients with TP53 mutations (non‐CK/TP53mu) who were diagnosed and received therapy at our institute were enrolled. One hundred and fifty‐seven AML cases retrieved from the cancer genome atlas (TCGA) for validation. Results: Among CK‐AML patients, those with TP53 mutations (CK/TP53mu) had significantly lower rates of 1‐course induction complete remission (CR), 2‐year relapse‐free survival (RFS) and 2‐year overall survival (OS) than those without TP53 mutations (CK/TP53wt); whereas, abn(17p) did not have the above impacts; MK was significantly associated with a lower 2‐year OS rate but was not related to the rates of CR and RFS. Multivariate analysis showed that it were TP53 mutations and treating with chemotherapy alone but not MK and abn(17p) that independently predicted the adverse prognosis for RFS and OS in CK‐AML. Furthermore, non‐CK/TP53mu patients showed similar rates of CR, RFS and OS to CK/TP53mu patients. Validation using the TCGA cohort showed that CK/TP53mu patients had a significantly lower 2‐year OS rate than CK/TP53wt patients, whereas abn(17p) and MK did not impact OS; the 2‐year OS rate of patients with CK/TP53wt was similar to that of patients with intermediate‐risk cytogenetics. Conclusion: Adult CK‐AML patients have varied risks and TP53 mutations seem to be an independent adverse prognostic factor. [ABSTRACT FROM AUTHOR]

As a newly developed classification system, the LCZ scheme provides a research framework for Urban Heat Island (UHI) studies and standardizes the worldwide urban temperature observations. With the growing popularity of deep learning, deep learning-based approaches have shown great potential in LCZ mapping. Three major cities in China are selected as the study areas. In this study, we design a deep convolutional neural network architecture, named Residual combined Squeeze-and-Excitation and Non-local Network (RSNNet), that consists of the Squeeze-and-Excitation (SE) block and non-local block to classify LCZ using freely available Sentinel-1 SAR and Sentinel-2 multispectral imagery. Overall Accuracy (OA) of 0.9202, 0.9524 and 0.9004 for three selected cities are obtained by applying RSNNet and training data of individual city, and OA of 0.9328 is obtained by training RSNNet with data from all three cities. RSNNet outperforms other popular Convolutional Neural Networks (CNNs) in terms of LCZ mapping accuracy. We further design a series of experiments to investigate the effect of different characteristics of Sentinel-1 SAR data on the performance of RSNNet in LCZ mapping. The results suggest that the combination of SAR and multispectral data can improve the accuracy of LCZ classification. The proposed RSNNet achieves an OA of 0.9425 when integrating the three decomposed components with Sentinel-2 multispectral images, 2.44% higher than using Sentinel-2 images alone. [ABSTRACT FROM AUTHOR]

Background: The KODEX-EPD system is a novel, dielectric three-dimensional mapping system. We aim to illustrate the feasibility, safety, and outcomes of ablation using the KODEX-EPD system.Methods: A total of 272 patients with supraventricular arrhythmias were enrolled and underwent catheter ablation using the KODEX-EPD system from October 2020 to July 2021. The feasibility, safety, and ablation outcomes were analyzed.Results: Of the enrolled patients, 15 (5.4%) had atrial tachycardia (AT), 88 (31.4%) had atrioventricular reentrant tachycardia (AVRT), 141 (50.4%) had atrioventricular nodal reentrant tachycardia (AVNRT), 34 (12.1%) had atrial fibrillation (AF), and 9 (3.2%) had atrial flutter (AFL). All AF patients included were first-do-pulmonary vein isolation (PVI); there were 26 paroxysmal AF and 8 persistent AF. All patients achieved immediate success of ablation. The mean follow-up duration was 11.8 ± 2.4 months. One patient (1.1%) in the AVRT subgroup and two patients (1.4%) in the AVNRT subgroup experienced recurrence. When considering a three-month blanking time, the estimated freedom of AF at one-year post-ablation with and without AADs was 75.7% and 70.4%, respectively. The Kaplan-Meier analysis showed no significant difference in the overall AF recurrence (log-rank; P = 0.931) or AAD-free AF recurrence (log-rank; P = 0.841) between RFCA and cryoablation. One patient had mild pulmonary embolism. None of the patients died or had a cerebrovascular event in the periprocedural period.Conclusions: This retrospective, two-center study demonstrated that catheter ablation of supraventricular arrhythmias using the KODEX-EPD system is feasible, safe, and effective. Trial registration Retrospectively registered. [ABSTRACT FROM AUTHOR]

In order to promote the economic development of China's provinces and provide references for the provinces to make effective economic decisions, it is urgent to investigate the trend of province-level economic development. In this study, DMSP/OLS data and NPP/VIIRS data were used to predict economic development. Based on the GDP data of China's provinces from 1992 to 2016 and the nighttime light remote sensing (NTL) data of corresponding years, we forecast GDP via the linear model (LR model), ARIMA model, ARIMAX model, and SARIMA model. Models were verified against the GDP records from 2017 to 2019. The experimental results showed that the involvement of NTL as exogenous variables led to improved GDP prediction. [ABSTRACT FROM AUTHOR]

Nitryl chloride (ClNO2) is an important chlorine reservoir in the atmosphere that affects the oxidation capacity by producing first‐ and second‐generation radicals, but it has been rarely observed in the world. Here, online measurements of both N2O5 and ClNO2 at a coastal background site in the Pearl River Delta (PRD) in southern China, a region with high atmospheric oxidation capacity in the daytime, are presented. We observed continuous accumulation of elevated ClNO2 at night, while N2O5 was generally low. The maximum concentrations of N2O5 and ClNO2 were 1.4 and 1.7 ppbv, respectively, associated with a transported urban plume with high levels of O3 and NO2. The average product of N2O5 uptake coefficient and ClNO2 yield (γ × f = 0.02, with average γ of 0.027 and f of 0.71) was roughly twice those in urban areas in China, indicating active N2O5 heterogenous chemistry and effective ClNO2 formation in the background atmosphere. The production rate of Cl radicals (pCl) from the photolysis of ClNO2 was estimated to be an order of magnitude higher than those at coastal and rural sites in the literature. Such levels of Cl radical production could have considerable contribution to the atmospheric oxidation capacity after sunrise. In addition, NO2 produced by ClNO2 photolysis in the morning accounted for approximately 10% of the NO2 increase within several hours after sunrise. Thus, high nocturnal ClNO2 production and its following daytime photochemistry should be considered seriously in regional air quality modeling in the PRD and regions with similar conditions. Plain Language Summary: The heterogeneous process of reactive nitrogen oxides on aerosol surfaces has been increasingly recognized as an essential pathway for nitrate formation and halogen activation in urban and polluted environments. Despite its importance, large variations exist in the uptake coefficient and product yields, and the quantitative understanding is still limited. In this study, field measurements of dinitrogen pentoxide (N2O5) and nitryl chloride (ClNO2) were conducted to quantify their heterogenous reactivity and subsequent impacts at a coastal background site in southern China. The determined heterogeneous reactivity in the background atmosphere was even higher than in previous observations in urban areas. The accumulated high ClNO2 at night could lead to efficient production of chlorine atoms and recycling of NOx in the following morning, significantly affecting the next‐day photochemistry and oxidants formation. The findings highlight the important roles of nocturnal heterogeneous nitrogen chemistry and the need to comprehensively incorporate those processes in air quality models to understand better the atmospheric chemistry in background air. Key Points: Nocturnal N2O5 and ClNO2 were observed with distinct features in different air massesN2O5 heterogeneous chemistry did not completely destroy Ox but also served as a potential source of OxContinuous accumulation of nocturnal ClNO2 had an important impact on atmospheric oxidation capacity and NOx budget in the next morning [ABSTRACT FROM AUTHOR]

Two new species of Globisporangium, G. pengfuense and G. tenuihyphum, that were isolated from soybean in China are described and illustrated based on their morphological characters and molecular evidence. The characteristics of G. pengfuense include globose to sub-globose sporangia that are: catenulate, terminal, occasionally with apical papillae or intercalary, smooth oogonia, mostly monoclinous, occasionally diclinous antheridia, fist-shaped to crook-necked, with straight or curved antheridial cells, and plerotic or nearly plerotic with thin-walled oospores (0.5–1.0 µm). Globisporangium tenuihyphum differs from other species in this genus by its relatively narrow hyphae that are: mostly sub-globose to globose, occasionally ovoid-obpyriform sporangia, smooth oogonia, monoclinous antheridia, subclavate, falcate or semicircular to subcircular antheridial cells, and with aplerotic oospores. Phylogenetically, data from the combined internal transcribed spacer (ITS) and cytochrome c oxidase subunit I (Cox1) sequences support the designation of G. pengfuense and G. tenuihyphum as two distinct species of Globisporangium (Pythium sensu lato clades G and J). In addition, the two new species were compared to closely related Globisporangium species, to delineate their phylogenetic positions and morphological features. [ABSTRACT FROM AUTHOR]

Wine produced by fermentation of Chestnut rose (Rosa roxburghii) hips, known as cili (Chinese-Mandarin), in Guizhou province, and other places in China is becoming popular but there is limited knowledge of suitable yeast strains for its production. In this study, we first investigated the oenological properties of six commercial S. cerevisiae yeast strains (X16, F33, SH12, GV107, S102, RMS2), one commercial Saccharomyces cerevisiae var. bayanus (S103), one commercial, non-Saccharomyces yeast strain, Torulaspora delbrueckii Prelude, and one indigenous S. cerevisiae strain, CZ, for cili wine fermentation. We measured the key traits of each of the yeast strains, viz., sulfite resistance, flocculation, hydrogen sulfide production capacity, fermentation rate, and yeast growth curves. Subsequently, we measured the resultant wine characteristics, viz., pH, alcohol content, residual sugar, titratable acidity, volatile acidity, ascorbic acid content and headspace volatile compounds. The overall suitability of each yeast type was evaluated using a multi-factor, unweighted, scorecard. On that basis, RMS2 was the most suitable, and closely followed by CZ and X16. This study is the first comparative evaluation of yeasts for cili wine production and provides a preliminary guide for their selection. [ABSTRACT FROM AUTHOR]

Urban–rural land transition and the coordination of coupled human–environmental systems are two important issues in the process of global urban–rural development. Although existing studies have explored the coupling coordination degree (CCD) of human–environmental interactions under the context of urbanization, few studies have taken land transitions into consideration. In this study, we investigated the dynamics of CCD in China from 2001 to 2018 using multisource remote sensing data and quantified the CCD changes in land transitions among urban construction land (UCL), rural residential land (RRL), and non-construction land (NCL). The CCD alterations mainly occurred in the decline in NCL stock, the increase in UCL stock, and especially the losses during RRL to NCL transfers. We urge academics and government decision-makers to pay more attention to the CCD transfers and losses during urban–rural transitions. This study provides scientific guidance for the development of urban–rural integration and is expected to assist the coordinated evaluation of human–environmental interactions in the process of sustainable development. [ABSTRACT FROM AUTHOR]

A landslide always results from a progressive process of slope deformation. In recent years, an increasing number of slope instabilities have occurred with regard to human engineering activities such as hydropower or traffic construction in mountainous area, which cause even greater casualties and economic loss compared with the natural hazards. The development of such earth surface process may hold long period with mechanisms still not fully understood. Using monitoring technology is an effective and intuitive approach to assist analyzing the slope deformation process and their driving factors. This study presents an engineering slope excavated during the construction of Changheba Hydropower Station, which is located in the upper reaches of Dadu River, Sichuan Province, southwest China. The engineering slope experienced and featured a five-year continuous deformation which caused continuous high risks to the engineering activities. We conducted in-depth analysis for such a long-term deformation process based on ground and subsurface monitoring data, collected successive data with a series of monitoring equipment such as automated total station, borehole inclinometers and other auxiliary apparatus, and identified the deformation process based on the comprehensive analysis of monitoring data as well as field investigation. After analyzing the effects of engineering activities and natural factors on the continuous deformation, we found that the overburden strata provided deformable mass while the excavation-produced steep terrain initiated the slope deformation in limit equilibrium state over a long period of time; afterwards, the intense rainwater accelerated slope deformation in the rainy season. [ABSTRACT FROM AUTHOR]

[Display omitted] • Dunde magnetite was crystallized from high-temperature, high-salinity, Fe-Zn-rich fluids. • Intensive fluid-rock interaction further increased the content of Zn and Fe in the fluids. • The multiple re-equilibration processes of magnetite contribute to the enrichment of Zn. The West Tianshan in the Central Asian Orogenic Belt is one of important Fe belts in China, where many submarine volcanogenic iron-oxide deposits constitute the Awulale metallogenic belt. The Dunde deposit is a Fe-Zn-Au deposit, whereas Chagangnuoer, Zhibo, and Beizhan are Fe-dominated deposits. To examine the factors controlling the formation of Fe polymetallic deposits, the texture and chemical composition of magnetite from the Dunde deposit were studied in detail and compared with those of other deposits in the same belt. The Dunde deposit magnetite can be divided into Mag-1, Mag-2, and Mag-3, which correspond to stages of retrograde, sulfide, and carbonate stages, respectively. They have experienced oxy-exsolution and coupled dissolution and reprecipitation (CDR), forming multiple generations of magnetite. The exsolution of gahnite in Mag-1 and 10 times higher Zr, Hf, Sc, Ta, Nb, Mn, and Zn contents in the all stages of magnetite than those of Fe-dominated deposits, indicating the Dunde magnetite was crystallized from high-temperature, high-salinity, Fe-Zn-rich fluids. The similar chalcophile element contents in host volcanic rocks between Dunde and other deposits indicate host volcanic rocks are not the reason for Zn enrichment in Dunde. The higher Mg + Mn and Si + Al contents in Dunde magnetite than magnetite of other deposits indicate stronger fluid-rock interaction. Extensive CDR texture in Mag-1 and Mag-2 and lower Zn in secondary magnetite indicate that Zn leached from Zn-rich magnetite may have also contributed to the formation of sphalerite in sulfide stage. Our study has demonstrated that high-temperature, high-salinity, Fe- and Zn-rich primary fluids, a higher degree of fluid-rock interaction, and repeated fluid infiltration are key factors controlling the formation of Fe-Zn polymetallic deposits, such as the Dunde deposit in West Tianshan. [ABSTRACT FROM AUTHOR]

Objectives: Gastric varices (GV), a common complication of liver cirrhosis, often cause serious consequences. However, the management of GV remains debated. In this study we aimed to explore the practice patterns of Chinese practitioners in GV treatment and discuss whether these patterns conform to the guidelines in China and around the world. Methods: Between October 2020 and January 2021, an online questionnaire was sent to doctors from different regions in China via WeChat. Data on the practice patterns for endoscopic treatment with and without a multidisciplinary discussion team (MDT) clinic for GV were analyzed. Results: Questionnaires were collected from 241 practitioners from 29 provinces in China. Before endoscopic treatment, 100 (41.5%) of the practitioners arranged computed tomography angiography (CTA) examination. In endoscopic tissue adhesive (ETA) treatment, 183 (75.9%) of the practitioners chose ETA combined with lauromacrogol. Approximately one‐fourth of all practitioners did not prescribe drugs to reduce portal pressure. Only 75 (31.1%) of physicians preferred using early transjugular intrahepatic portosystemic shunt (TIPS) for patients at a high risk of treatment failure for GV. Compared to those without MDT clinics, practitioners with MDT clinics more often chose early TIPS for high‐risk patients (39.0% vs 18.9%, P = 0.001). Conclusions: Treatment for GV differ across China. Practitioners with MDT clinics can better use assistant strategies such as CTA to evaluate the risk and efficacy. Further clinical studies are needed, and more guidelines and consensuses are warranted to standardize clinical practice for GV. [ABSTRACT FROM AUTHOR]

Background: For initial respiratory management, continuous positive airway pressure (CPAP) is increasingly used for preterm infants, especially for gestational age less than 32 weeks. However, neonatologists are concerned about the potential risks of CPAP support failure. Objectives: To examine the association between different initial respiratory support modalities and the outcomes of preterm infants at <32 weeks of gestation across multiple neonatal intensive care units (NICU) in China. Methods: This study was carried out over a period of 12 months in 2018. Unadjusted relative risks (RR) for demographic and clinical characteristics were calculated for CPAP failure and CPAP success in the total cohort using log‐linear model based on generalised estimating equations for clustered observations. Results: Among 1560 preterm infants delivered at <32 weeks, the incidence of CPAP failure was 10.3%. After adjustment for demographic and clinical factors, the relative risk of mortality (RR 7.54, 95% CI 5.56, 10.44), pneumothorax (RR 9.85, 95% CI 2.89, 61.53), pulmonary haemorrhage (RR 7.78, 95% CI 4.51, 14.64) and BPD (RR 3.65, 95% CI 3.65, 4.51) were considerably higher for infants in the CPAP failure group than those in the CPAP‐S group. However, the risk of poor outcomes in CPAP failure infants was similar to that of those in the initial mechanical ventilation (MV) group. Conclusions: Continuous positive airway pressure failure was associated with an increased risk of mortality and major morbidities, including BPD, pulmonary haemorrhage and pneumothorax, and was comparable to the risk associated with initial MV. [ABSTRACT FROM AUTHOR]

Background: Recent evidence of genetics and metabonomics indicated a potential role of apolipoprotein M (ApoM) in the pathogenesis of Alzheimer's disease (AD). Here, we aimed to investigate the association between plasma ApoM with AD. Methods: A multicenter, cross-sectional study recruited patients with AD (n = 67), age- and sex-matched cognitively normal (CN) controls (n = 73). After the data collection of demographic characteristics, lifestyle risk factors, and medical history, we examined and compared the plasma levels of ApoM, tau phosphorylated at threonine 217 (p-tau217) and neurofilament light (NfL). Multivariate logistic regression analysis was applied to determine the association of plasma ApoM with the presence of AD. The correlation analysis was used to explore the correlations between plasma ApoM with cognitive function [Mini–Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)], activities of daily living (ADL), and the representative blood-based biomarkers (plasma p-tau217 and NfL). Receiver operating characteristic (ROC) analysis and Delong's test were used to determine the diagnostic power of plasma ApoM. Results: Plasma ApoM and its derived indicators (ratios of ApoM/TC, ApoM/TG, ApoM/HDL-C, and ApoM/LDL-C) were significantly higher in AD group than those in CN group (each p < 0.0001). After adjusted for the risk factors of AD, the plasma ApoM and its derived indicators were significantly associated with the presence of AD, respectively. ApoM (OR = 1.058, 95% CI: 1.027–1.090, p < 0.0001), ApoM/TC ratio (OR = 1.239, 95% CI: 1.120–1.372, p < 0.0001), ApoM/TG ratio (OR = 1.064, 95% CI: 1.035–1.095, p < 0.0001), ApoM/HDL-C ratio (OR = 1.069, 95% CI: 1.037–1.102, p < 0.0001), and ApoM/LDL-C ratio (OR = 1.064, 95% CI:1.023–1.106, p = 0.002). In total participants, plasma ApoM was significantly positively correlated with plasma p-tau217, plasma NfL, and ADL (each p < 0.0001) and significantly negatively correlated with MMSE and MoCA (each p < 0.0001), respectively. In further subgroup analyses, these associations remained in different APOE ϵ 4 status participants and sex subgroups. ApoM/TC ratio (ΔAUC = 0.056, p = 0.044) and ApoM/TG ratio (ΔAUC = 0.097, p = 0.011) had a statistically remarkably larger AUC than ApoM, respectively. The independent addition of ApoM and its derived indicators to the basic model [combining age, sex, APOE ϵ 4, and body mass index (BMI)] led to the significant improvement in diagnostic power, respectively (each p < 0.05). Conclusion: All the findings preliminarily uncovered the association between plasma ApoM and AD and provided more evidence of the potential of ApoM as a candidate biomarker of AD. [ABSTRACT FROM AUTHOR]

Freshwater mussels are known to have two types of mitochondrial DNA (mtDNA) transmitted separately through oocytes and sperms, namely, maternal (F‐type) and paternal (M‐type) mtDNA. The additional suite of mitochondrial genes provides a great opportunity to resolve phylogenetically problematic relationships. East Asian freshwater mussels of the genus Cuneopsis were considered a compact group of taxa having wedge‐shaped shells. However, preliminary results from previous studies challenged the monophyly of Cuneopsis, and the exact phylogenetic relationships among Cuneopsis and its allied genera are yet to be determined with comprehensive species sampling. Here, we evaluated species boundaries in Cuneopsis based on COI barcoding and obtained 11 new F‐ and M‐type mitogenomes via genome skimming to elucidate the evolutionary history of Cuneopsis. COI barcode data supported the validity of all sampled six Cuneopsis species (missing C. kiangsiensis). Our mitochondrial phylogenomic analyses confirmed that the currently recognized genus Cuneopsis sensu lato was polyphyletic, recovering three well‐supported clades. Molecular dating analysis suggested Cuneopsis s.l. diversified at ~58.06 million years ago in the Paleogene. Hereby, we propose two new genera, that is, Arcuneopsis gen. nov. and Pseudocuneopsis gen. nov. Additionally, we report a new species, Pseudocuneopsis sichuanensis sp. nov., from Chengdu, Sichuan, China, and a newly recorded species from China, Cuneopsis demangei. [ABSTRACT FROM AUTHOR]

Background: Diabetic retinopathy (DR) has become a leading cause of global blindness as a microvascular complication of diabetes. Regular screening of diabetic retinopathy is strongly recommended for people with diabetes so that timely treatment can be provided to reduce the incidence of visual impairment. However, DR screening is not well carried out due to lack of eye care facilities, especially in the rural areas of China. Artificial intelligence (AI) based DR screening has emerged as a novel strategy and show promising diagnostic performance in sensitivity and specificity, relieving the pressure of the shortage of facilities and ophthalmologists because of its quick and accurate diagnosis. In this study, we estimated the cost-effectiveness of AI screening for DR in rural China based on Markov model, providing evidence for extending use of AI screening for DR.Methods: We estimated the cost-effectiveness of AI screening and compared it with ophthalmologist screening in which fundus images are evaluated by ophthalmologists. We developed a Markov model-based hybrid decision tree to analyze the costs, effectiveness and incremental cost-effectiveness ratio (ICER) of AI screening strategies relative to no screening strategies and ophthalmologist screening strategies (dominated) over 35 years (mean life expectancy of diabetes patients in rural China). The analysis was conducted from the health system perspective (included direct medical costs) and societal perspective (included medical and nonmedical costs). Effectiveness was analyzed with quality-adjusted life years (QALYs). The robustness of results was estimated by performing one-way sensitivity analysis and probabilistic analysis.Results: From the health system perspective, AI screening and ophthalmologist screening had incremental costs of $180.19 and $215.05 but more quality-adjusted life years (QALYs) compared with no screening. AI screening had an ICER of $1,107.63. From the societal perspective which considers all direct and indirect costs, AI screening had an ICER of $10,347.12 compared with no screening, below the cost-effective threshold (1-3 times per capita GDP of Chinese in 2019).Conclusions: Our analysis demonstrates that AI-based screening is more cost-effective compared with conventional ophthalmologist screening and holds great promise to be an alternative approach for DR screening in the rural area of China. [ABSTRACT FROM AUTHOR]

Purpose. To quantify the long-term evaluation of optic chiasma (OC) and/or optic nerve(s) (ONs) and to develop predictive models for radiation-induced optic neuropathy (RION) in nasopharyngeal carcinoma after intensity-modulated radiotherapy (IMRT). Methods and Materials. A total of 3,662 patients' OC/ONs with full visual acuity and dosimetry data between 2010 and 2015 were identified. Critical dosimetry predictors of RION were chosen by machine learning and penalized regression for survival. A nomogram containing dosimetry and clinical variables was generated for predicting RION-free survival. Results. The median follow-up was 71.79 (2.63–120.9) months. Sixty-six eyes in 51 patients (1.39%) developed RION. Two patients were visual field deficient, and 49 patients had visual acuity of less than 0.1 (20/200). The median latency time was 36 (3–90) months. The 3-, 5-, and 8-year cumulative incidence of RION was 0.78%, 1.19%, and 1.97%, respectively. Dmax was the most critical dosimetry variable for RION (AUC: 0.9434, the optimal cutoff: 64.48 Gy). Patients with a Dmax ≥64.48 Gy had a significantly higher risk of RION (HR = 102.25; 95%CI, 24.86–420.59; P < 0.001). Age (>44 years) (HR = 2.234, 95% CI = 1.233–4.051, p = 0.008), advanced T stage (T3 vs. T1-2: HR = 7.516, 95% CI = 1.725–32.767, p = 0.007 ; T4 vs. T1-2: HR = 37.189, 95% CI = 8.796–157.266, P < 0.001), and tumor infiltration/compression of the OC/ONs (HR = 4.572, 95% CI = 1.316–15.874, p = 0.017) were significant clinical risk factors of RION. A nomogram comprising age, T stage, tumor infiltration/compression of the OC/ON, and Dmax significantly outperformed the model, with only Dmax predicting RION (C-index: 0.916 vs. 0.880, P < 0.001 in the training set; 0.899 vs. 0.874, P = 0.038 in the test set). The nomogram-defined high-risk group had a worse 8-year RION-free survival. Conclusions. In the IMRT era, Dmax <60 Gy is safe and represents an acceptable dose constraint for most NPC patients receiving IMRT. A reasonable trade-off for selected patients with unsatisfactory tumor coverage due to proximity to the optic apparatus would be Dmax <65 Gy. Caution should be exercised when treating elderly and advanced T-stage patients or those with tumor infiltration/compression of the OC/ON. Our nomogram shows strong efficacy in predicting RION. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the efficacy and safety of Hengli® Chinese botulinum toxin type A (BTX-A; 100 U) in Chinese patients with overactive bladder. Methods: This study was a multicenter, randomized, double-blind, placebo-controlled trial in Chinese patients who were inadequately managed with anticholinergic medications. Eligible patients were randomized 2:1 to receive intradetrusor injections of Hengli® BTX-A (n = 144) or placebo (n = 72). The primary endpoint was the change in the number of daily micturition episodes at week 6 from baseline. The secondary efficacy endpoints included the average frequency of urgency and urinary incontinence (UI) episodes per day, urgency score, average micturition volume per day, OABSS, and QoL score. Results: In the Hengli® BTX-A group, there was a significantly greater reduction in the average number of micturition episodes per 24 h compared with the placebo group (3.28 vs. 1.43; p = 0.003). Moreover, there was a significantly greater improvement in the daily number of urgency episodes, micturition volume and OABSS score. An increased post-void residual urine volume, dysuria, and urinary tract infection represented adverse events (AEs) in the Hengli® BTX-A group. Most AEs were mild or moderate in severity. One patient in the BTX-A group initiated clean intermittent catheterization (CIC) during treatment. Conclusion: Hengli® BTX-A treatment was well-tolerated and resulted in significant improvements in OAB symptoms among Chinese patients inadequately managed by anticholinergics. Clinical Trial Registration: http://www.chinadrugtrials.org.cn/clinicaltrials.prosearch.dhtml, Identifier: CTR20131190. [ABSTRACT FROM AUTHOR]

Background: Increasing studies have focused on the predictive value of high estimated glomerular filtration rate (eGFR) on cardiovascular diseases and mortality; however, the association between high eGFR with cognitive function is still not established. Thus, this study aimed to determine the co-relationship between high eGFR and cognitive performance in the hypertensive population. Methods: We conducted a baseline cross-sectional study using data from the China H-type Hypertension Registry study. Mini-Mental State Examination (MMSE) assessment was performed to evaluate the cognitive function scale, and serum creatinine was collected to estimate eGFR level. Different MMSE cutoff values were applied in participants with the various educational background to define dementia: <24 in participants with secondary school and above education setting, <20 in those with primary school, and <17 in illiterate participants. Results: A total of 9,527 hypertensive adults with mean age 63.7 ± 9.8 years and 67% female gender were analyzed. The eGFR cutoff value of 71.52 ml/min/1.73 m2 was found after adjusting for potential covariates in a threshold effect analysis. The MMSE increased significantly with the increment of eGFR (β, 0.27; 95% CI: 0.12–0.41) in participants with eGFR < 71.52 ml/min/1.73 m2 and decreased (β, −0.28; 95% CI: −0.39 to −0.17) in participants with eGFR ≥ 71.52 ml/min/1.73 m2. Individuals with eGFR ≥ 85 ml/min/1.73 m2 have an elevated risk of cognitive impairment than those with eGFR of 65–75 ml/min/1.73 m2. Subgroup analysis showed that a greater reduction degree of MMSE was observed in female individuals and those who had body mass index (BMI) ≥ 24 kg/m2 among participants with eGFR ≥ 71.52 ml/min/1.73 m2. Conclusion: Our findings observed an inverted U-shaped relationship between eGFR and cognitive function. Both the low and high levels of eGFR were independently associated with worse cognitive assessment in the hypertensive population. [ABSTRACT FROM AUTHOR]

Background. Previous studies have revealed the triglyceride-glucose (TyG) index is closely related to hyperuricemia in the general population. However, this relationship in hypertensive patients has not been reported. The aims of this study are to investigate the relationship of the TyG index and hyperuricemia in adult Chinese hypertension. Methods. The China H-type Hypertension Registration (an observational, noninterventional, and real-world study) was conducted from March 01, 2018, to August 31, 2018, in 16 communities in Wuyuan of China. The TyG index was calculated from fasting triglycerides (mg/dL) and fasting glucose (mg/dL)/2. Hyperuricemia was categorized by uric acid concentration ≥420 μmol/L (7 mg/dL). Results. Overall average TyG index of 13,060 adults with hypertension was 8.87; age was 63.81 years. The TyG index was positively correlated with serum uric acid by multiple linear regression analyses (β = 38.03; 95% CI: 34.55 to 41.51). Coincidentally, logistic analyses also demonstrated the TyG index had a positive correlation with hyperuricemia (OR = 2.04; 95% CI: 1.87 to 2.24). Strong linear associations of the TyG index with serum uric acid and hyperuricemia were confirmed by restricted cubic spline analysis. Compared with subjects in the lowest quartile (7.13 to 8.44) of the TyG index, subjects in the 2nd–4th quartiles had 1.25 (95% CI: 1.10 to 1.41), 1.63 (95% CI: 1.43 to 1.86), and 2.79 (95% CI: 2.41 to 3.24) times greater incident risk of developing hyperuricemia. The TyG index had significant correlations between male patients and hyperuricemia (OR = 2.01) by subgroup analysis. Conclusion. Positive associations were found between the TyG index and serum uric acid and between the TyG index and hyperuricemia in adults with hypertension. This trial was registered at clinicaltrials.gov as ChiCTR1800017274. [ABSTRACT FROM AUTHOR]