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Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium Tuberculosis (MTB). It is the second largest single cause of death besides novel coronavirus pneumonia. Along with the abuse of antibiotics and extensive use of anti-tuberculosis drugs, multidrug-resistant (MDR) TB, drug-resistant (XDR) TB and totally drug-resistant (TDR) TB became obstacles to the tuberculosis eradication worldwide. According to the World Health Organization (WHO) statistics, China is not only a high burden tuberculosis country in the world, but also a country with a serious epidemic of MDR. Traditional drugs fail to meet the needs of tuberculosis control. Therefore, it is urgent to find new targets of anti-tuberculosis drugs and develop new anti-tuberculosis drugs. Hence, this paper systematically summarizes the mechanism of traditional and newly developed anti-tuberculosis drugs, in which stressing the research progress of drug resistance mechanisms. This work provides us with new insights of new antituberculosis drug developments, and may contribute to a reduction in the harm that tuberculosis brings to society. [ABSTRACT FROM AUTHOR]

It is widely accepted that environmental degradation and poverty are linked and that conservation and poverty reduction should be tackled together. However, success with integrated strategies has been elusive. Here, we present the results of a study that illustrates how development that combines environmental and economic perspectives and that provides appropriate compensation to affected populations can improve both nature and society, thereby eradicating the "poverty trap." The results show that if we cannot improve the livelihood of local residents, we will be unable to restore degraded environments when state-owned property is transferred to private ownership to encourage better management by residents. In contrast, measures to eliminate poverty, combined with the development of green enterprises that improve the livelihoods of private land owners in the long term, is the precondition for successful ecological restoration. [ABSTRACT FROM AUTHOR]

Sarcomyxa edulis, a notable edible and medicinal mushroom indigenous to northeast China, is celebrated for its high nutritional value and delightful taste. In this study, white light as a control and examined the effects of red, green, and blue light on the agronomic traits, antioxidant capabilities, and nutritional composition of S. edulis. The results showed that different monochromatic light qualities affected the color of S. edulis pileus, with blue light demonstrating particular efficacy. Furthermore, blue light also regulated pileus length, whereas red light was instrumental in significantly increasing stalk length. Regarding antioxidant capacity, compared with red and green light, the activities of POD, SOD, and CAT were significantly improved by blue light irradiation, decreased MDA levels, and improved free radical scavenging potential. Additionally, blue light exposure led to an increase in the contents of 15 amino acids. Green light treatment reduced the crude fat content. For the first time, we found that light quality is a key factor in controlling the color of S. edulis. Blue light is an effective way to regulate the color and pileus size of S. edulis, and improve the antioxidant properties. The photobiological characteristics and the response of nutritional quality to light environment of S. edulis were clarified., (© 2024. The Author(s).)

Eleven undescribed cembrane-type diterpenoids, named litoamentenes A-K (1-11), were isolated from the soft coral Litophyton amentaceum collected from the South China Sea. Their structures were elucidated by extensive analysis of spectroscopic data, comparison with the literature data, single crystal X-ray diffraction, quantum chemical calculations and TDDFT-ECD calculations. This is the first systematic investigation of L. amentaceum. In particular, compounds 1-3 are cembrane-type norditerpenoids that lack isopropyl side chains. Compound 6 is a cembrane-type norditerpenoid without a methyl group at C-4, the first natural product identified with this carbon skeleton. Compounds 6, 9 and 10 showed modest cytotoxicity against several human cancer cell lines with IC 50 values ranging from 3.99 to 14.56 μM., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)