1. Nucleoside and N-acetyldopamine derivatives from the insect Aspongopus chinensis.
- Author
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Yan YM, Luo Q, Di L, Shi YN, Tu ZC, and Cheng YX
- Subjects
- Animals, Carbon-Carbon Lyases chemistry, Carbon-Carbon Lyases isolation & purification, Cell Line, Tumor, China, Cyclooxygenase 2, Cyclooxygenase Inhibitors chemistry, Cyclooxygenase Inhibitors isolation & purification, Dopamine chemistry, Dopamine isolation & purification, Humans, Janus Kinase 3 antagonists & inhibitors, Molecular Structure, Nucleosides isolation & purification, rho-Associated Kinases antagonists & inhibitors, Dopamine analogs & derivatives, Heteroptera chemistry, Nucleosides chemistry
- Abstract
Two new nucleoside derivatives, named asponguanosines A and B (1 and 2), three new N-acetyldopamine analogues, aspongamides C-E (3-5), one new sesquiterpene, aspongnoid D (6), and three known compounds were isolated from the medicinal insect Aspongopus chinensis. Their structures including absolute configurations were assigned by using spectroscopic methods and ECD and
13 C NMR calculations. Biological activities of compounds 3-7 towards human cancer cells, COX-2, ROCK1, and JAK3 were evaluated., (Copyright © 2018 Elsevier B.V. All rights reserved.)- Published
- 2019
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