7 results on '"Jin, Zhuo"'
Search Results
2. Glycyrrhizic acid suppresses atopic dermatitis‐like symptoms by regulating the immune balance.
- Author
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Hou, Dian‐Dong, Wang, Xin‐Xin, Li, Si‐Jia, Wang, De‐Cheng, Niu, Yuan, Xu, Zi‐Ran, and Jin, Zhuo‐Qun
- Subjects
THYMIC stromal lymphopoietin ,CHINESE medicine ,LANGERHANS cells ,IMMUNOGLOBULIN E ,CHOLECALCIFEROL ,GLATIRAMER acetate ,ATOPIC dermatitis - Abstract
Background: Glycyrrhiza is one of the most widely used traditional Chinese medicines in China. Its main bioactive ingredient glycyrrhizic acid (GA) has the potential to be used as a treatment for atopic dermatitis (AD) because it has similar actions to steroids, but with relatively few side effects. Aims: The objective of this study was to explore the potential mechanisms of GA on AD mice model. Methods: Calcipotriol, a vitamin D3 analogue (MC903) was applied topically to establish AD mouse model. Mice were intraperitoneally administrated with 2 mg/kg dexamethasone (DEX), 25 or 50 mg/kg GA for 15 days. After mice were executed, skin tissues were collected and detected the expression levels of IL‐4, IFN‐γ, TNF‐α and thymic stromal lymphopoietin (TSLP). The percentages of Th1, Th2, Th17, langerhans cells (LCs) in draining lymph nodes (dLNs) were measured by flow cytometry. Results: Our data demonstrated that GA improved the symptoms of AD by exerting anti‐inflammatory and anti‐allergic functions in vivo. We found that GA treatment decreased the level of total IgE in serum, suppressed ear swelling, reduced the infiltration of mast cells in skin lesions and decreased expressions of IL‐4, IFN‐γ, TNF‐α and TSLP in skin lesions. Furthermore, our experimental results demonstrated that GA suppressed the Th1/Th2/Th17‐immune responses in the dLNs, inhibited the migration of LCs in dLNs. Conclusions: In conclusion, our findings suggested potential therapeutic effects of GA against MC903‐induced AD‐like skin lesions in mice. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. Establishment of three new species of Rhabdoblatta Kirby, 1903 (Blattodea, Blaberidae, Epilamprinae) from China on the basis of molecular and morphological data.
- Author
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Guo L, Zhang ZY, Cai JZ, Wang ZQ, and Che YL
- Subjects
- Animals, China, Male, Female, Animal Structures anatomy & histology, Animal Structures growth & development, Organ Size, Animal Distribution, Ecosystem, Phylogeny, Body Size
- Abstract
Combining the results of morphological identification and molecular species delimitation (ABGD), with newly sequenced 23 COI fragments from three new species and seven known species of Rhabdoblatta, we describe three species of Rhabdoblatta, namely Rhabdoblatta maculosa Guo et Che, sp. n., Rhabdoblatta equalisinensis Guo et Che, sp. n. and Rhabdoblatta cavicola Guo et Che, sp. n. Their morphological and the Rhabdoblatta maculosa Guo et Che, sp. n. habitat photographs are also included. There is also a checklist of Chinese Rhabdoblatta species.
- Published
- 2024
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4. New eremophilane-type sesquiterpenes from Synotis solidaginea.
- Author
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Wei XY, Sun HB, Xi RY, Wu F, Liu YL, Jin ZL, Guo DL, Xia B, Wang F, and Zhou Y
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- Mice, Animals, RAW 264.7 Cells, Molecular Structure, China, Polycyclic Sesquiterpenes pharmacology, Polycyclic Sesquiterpenes isolation & purification, Nitric Oxide metabolism, Sesquiterpenes pharmacology, Sesquiterpenes isolation & purification, Sesquiterpenes chemistry, Phytochemicals isolation & purification, Phytochemicals pharmacology
- Abstract
Eleven new highly oxygenated eremophilane-type sesquiterpenoids were isolated from the whole plant of Synotis solidaginea, including two pairs of C-8 S/R epimers. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configurations of 1 and 9 were confirmed by single-crystal X-ray crystallography using Cu Kα radiation. All the isolates were tested for the inhibition of LPS-stimulated NO production in macrophage-like mouse monocytic leukemia RAW264.7 cells. Compound 1 exhibited weak inhibitory effects with an IC
50 of 71.2 μM., Competing Interests: Declaration of competing interest The authors declare that they have no competing financial interest in this article., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
- Full Text
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5. Morphological and phylogenetic analyses reveal a new species of Anthracophyllum (Omphalotaceae, Agaricales) in Zhejiang Province, China.
- Author
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Yang WJ, Xu M, Zhang J, Zhou F, Le ZF, Tong WJ, Song HY, Jin ZH, Cheng QG, Zhou JP, Gao Y, Zhai ZJ, Hu HJ, Chen MH, Yin H, Wang J, and Hu DM
- Subjects
- Phylogeny, DNA, Fungal genetics, China, Agaricales, Basidiomycota
- Abstract
During the investigations of macrofungi resources in Zhejiang Province, China, an interesting wood rot fungus was collected. Based on morphological and molecular phylogenetic studies, it is described as a new species, Anthracophyllum sinense. A. sinense is characterized by its sessile, charcoal black and pleurotoid pileus, sparse lamellae occasionally branching, clavate basidia with long sterigmata [(3-)6-7(-8) μm], and non-heteromorphous cystidia. A. sinense establishes a separate lineage close to A. archeri and A. lateritium in the phylogenetic tree., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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6. Impact of infertility duration on female sexual health.
- Author
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Dong M, Xu X, Li Y, Wang Y, Jin Z, and Tan J
- Subjects
- Adult, Case-Control Studies, China epidemiology, Female, Humans, Infertility, Female complications, Infertility, Female pathology, Infertility, Female psychology, Prevalence, Sexual Dysfunctions, Psychological etiology, Stress, Psychological epidemiology, Stress, Psychological etiology, Time Factors, Young Adult, Infertility, Female epidemiology, Sexual Dysfunctions, Psychological epidemiology, Sexual Health statistics & numerical data
- Abstract
Background: Infertility, an important source of stress, could affect sexual life. Extensive studies suggest that the incidence of sexual dysfunction is highly prevalent in infertile women. As the duration of infertility increases, the level of stress is also likely to increase even further, and this could aggravate psychological pain and cause sexual dysfunction. However, the effect of infertility duration on sexual health is unclear., Methods: We conducted a case-control study in which 715 patients participated between September 1,2020 and December 25, 2020. We included patients diagnosed with infertility (aged between 20 to 45), who were divided into four groups according to their infertility durations: ≤ 2 years (Group I, n = 262), > 2 years but ≤ 5 years (Group II, n = 282), > 5 years but ≤ 8 years (Group III, n = 97), and > 8 years (Group IV, n = 74). A questionnaire survey on female sexual functions and psychological depression was administered to participants, and their female sexual functions and depression status were measured using the Female Sexual Function Index (FSFI) and Patient Health Questionnaire (PHQ-9), respectively., Results: As the number of years of infertility increased, the PHQ-9 score as well as the incidence of psychological depression increased significantly (p < 0.05), but the total score of FSFI and those of its six domains/sub-scales were not significantly different among the four groups. An analysis of the relevant factors affecting sexual functions, using the multivariable logistic regression model, revealed that when the infertility duration was greater than 8 years, there was a significant increase in the incidence of sexual dysfunction [adjusted odds ratios (AOR) = 5.158, 95% confidence interval (CI): 1.935-13.746, P = 0.001], arousal disorder (AOR = 2.955, 95% CI: 1.194-7.314, P = 0.019), coital pain (AOR = 3.811, 95% CI: 1.045-13.897, P = 0.043), and lubrication disorder (AOR = 5.077, 95% CI: 1.340-19.244, P = 0.017)., Conclusions: An increasing infertility duration is a risk factor for the occurrence of sexual dysfunction. Hence, as the infertility duration increases, the incidence of female sexual dysfunction and psychological distress could also increase, especially when the infertility duration is more than 8 years., (© 2021. The Author(s).)
- Published
- 2021
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7. Association between diurnal temperature range and respiratory tract infections.
- Author
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Ge WZ, Xu F, Zhao ZH, Zhao JZ, and Kan HD
- Subjects
- China, Emergency Service, Hospital statistics & numerical data, Humans, Respiratory Tract Infections epidemiology, Temperature
- Abstract
Objective: This study aimed to assess the association between emergency-room visits for respiratory tract infection (RTI) with diurnal temperature range (DTR), a weather parameter closely associated with urbanization and global climate change., Methods: We conducted a semiparametric time-series analysis to estimate the percentage increase in emergency-room visits for RTI associated with changes in DTR after adjustment for daily weather conditions (temperature and relative humidity) and outdoor air pollution., Results: DTR was significantly associated with daily emergency-room visits for RTI. An increase of 1 °C in the current-day (L0) and in the 2-day moving average (L01) DTR corresponded to a 0.94% [95% confidence interval (CI), 0.34%-1.55%] and 2.08% (95% CI, 1.24%-2.93%) increase in emergency-room visits for RTI, respectively., Conclusion: DTR was associated with increased risk of RTI. More studies are needed to understand the impact of DTR on respiratory health., (Copyright © 2013 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.)
- Published
- 2013
- Full Text
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