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The Yellow River flows through multiple provinces in China, shaping the North China Plain, the largest alluvial plain in China. As the control node of basin ecological environment, the confluence of Weihe River and Yellow River is deemed as the gateway to North China Plain. In this study, a numerical simulation of the Weihe River–Yellow River confluence is conducted using a 2D hydrodynamic model and a coupled transport model for dissolved oxygen–biochemical oxygen demand. The results show that: (i) The typical flow field with multiple backflow areas is formed at the stagnant area where main stream and tributary converge and abrupt channel change area in different hydrological periods. The spur dike here mainly affects the velocity of the Weihe River outlet. (ii) There is an obvious concentration transition mixing zone downstream of the confluence, and the width of the mixing zone gradually linear increases with the direction of water flow. (iii) The self‐purification ability of the confluence is strongest in dry period, weaker in level period, and weakest in wet period. Water bodies have stronger self‐purification capacity on riverbanks than in the middle, and it is stronger in the upper reaches of Weihe River compared to Yellow River. Lower reaches also have a stronger self‐purification capacity than upper reaches. The study results can serve as a scientific reference for protecting the ecological environment of the Yellow River. [ABSTRACT FROM AUTHOR]

For the purpose of obtaining the smaller uncertainties for H p(3) and D p lens in 90Sr/90Y beta reference fields, a new dose determination method based on the Monte-Carlo simulation was proposed. The conversion coefficients from the absorbed dose in air, at the reference point of the extrapolation ionisation chamber, D air, det to H p(3; α) and the conversion factors from D air, det to D p lens(α) were calculated with EGSnrc, respectively, for the irradiation angles from 0° to 60°. Compared with the dose determination method in International Organization for Standardization (ISO) 6980 standard, the uncertainty reductions of 7.7–52.8% for H p(3; α) and 7.9–55.0% for D p lens(α) were achieved, respectively. In addition, for the conversion coefficients from the reference absorbed dose D R to H p(3; α), the calculations were performed for more irradiation conditions, which are not included in the current ISO 6980 standard. For the calculations of the conversion factors from D R to D p lens(α), the eye and head phantoms with Chinese characteristics were utilised, which makes the conversion factors more suitable for use in China. [ABSTRACT FROM AUTHOR]

The development of congenital heart disease (CHD) is a complicated process and affected by multiple environmental factors, as genetic factors, and the interactions among those factors. Previous studies have shown that intrauterine hypoxic environment exposure is a risk factor of CHD, but the genetic factors involved in the process are not clear. In this study, given that tetralogy of Fallot (TOF) is a CHD with hypoxemia as its primary pathophysiological manifestation, an in silico analysis was performed to reveal the relationship between potential target genes (miR-124) with the energy metabolism in non-syndromic TOF patients' cardiomyocyte. Furthermore, the study investigated the correlation between the primary miR-124 (rs531564) polymorphism and CHD susceptibility in 432 sporadic patients and 450 controls from two different altitude provinces (city) in China. Our study indicated that the minor C allele of rs531564 correlated with reduced risk of CHD in the low altitude city. Besides, the C allele has elevated frequency in the high-altitude group. Therefore, our findings suggest that the minor C allele of rs531564 SNP may be involved in the reduction of the risk of CHD in a way that interacts with the intrauterine hypoxic environmental factors. [ABSTRACT FROM AUTHOR]

Vast palaeolakes once occupied the Qinghai‐Tibetan Plateau (TP). Analyses of the sedimentary records of these lakes could potentially provide an extensive dating archive. Many previously constructed age‐depth models simulating lacustrine cores have been principally based on radiocarbon (14C) dating. However, such dating could have been hampered by the so‐called ‘lake reservoir effect’ (LRE) and the reworking of lakebed sediments, resulting in inaccurate 14C age‐depth models and limiting interpretations of existing lacustrine palaeoclimatic records. Lake Linggo Co is located on the central TP, in one of the coldest and most arid regions of Tibet. We dated a 9.87‐m‐long lacustrine core extracted from the lakebed at a water depth of ~60 m using a combination of 210Pb, 14C and optically stimulated luminescence (OSL) techniques. Some 14C ages showed significant age reversals; all the 14C ages were much older than the 210Pb and OSL ages for the same depths. This could possibly be attributed to the presence of old, inherited carbon, causing the inherited 14C age to appear unstable during the deposition period. The 210Pb and OSL ages were roughly concordant, and were also consistent with the stratigraphical succession. We therefore suggest that 14C dating may, on its own, be inadequate for accurate dating of lacustrine sediment sites on the TP, and that the OSL method should also be applied in order to evaluate the reliability of any 14C ages. With this approach, we constructed an age‐depth model, revealing sedimentation rates of 1.7, 0.8, 6.8 and 0.6 mm a−1 between 0–1.9, 1.9–4.2, 4.2–4.4 and 4.4–9.4 ka, respectively. [ABSTRACT FROM AUTHOR]

Roots of Astragalus membranaceus, Angelica sinensis, Glycyrrhiza uralensis and Codonopsis pilosula, which were often used as herbs in traditional Chinese medicine, were analyzed by Instrumental Neutron Activation Analysis (INAA). The samples were collected in Gansu, northwest of China and irradiated at the 15 MW heavy water reactor in China Institute of Atomic Energy (CIAE). The induced activities were counted by a well calibrated low background γ-spectrometer equipped with a high efficiency coaxial high-purity germanium (HPGe) detector. The concentrations of eighteen trace elements (Ca, Fe, Na, Zn, Ba, Rb, Ce, Cr, La, Co, Th, Cs, Sb, Sc, Sm, Hf, Eu and Tb) in the herbs were determined. Possible links between pharmacological action of the herbs and content of some elements were also discussed in this paper. The measured results were compared with the reported values in literature. [ABSTRACT FROM AUTHOR]

The Yangtze River is the longest watercourse in China, where it flows through the most densely populated and richest regions. The upper course of the River (Jinsha River) has been recurrently blocked over the course of time. The dam-outburst flood process has exerted a significant impact on the river's drainage area. However, the frequency of such events along the course of the Yangtze River remains poorly investigated. In this study, damming chain sediments were identified in the First Bend area of the Yangtze River, and were dated using optically stimulated luminescence (OSL) and 14C techniques. The obtained ages would suggest that the river was dammed by a debris flow during the ~20–7 ka period, with a resulting paleolake covering an area of 40.79 km2 and having a water volume of 0.63 km3. Two outburst megafloods occurred at ~18–20 and ~ 6.0 ka, respectively. The river was re-dammed again during 1.5–0.4 ka, with a lake coverage of 28.20 km2 and water volume of 0.28 km3. The dammed lake may have been gradually breached after ~0.4 ka. The damming events were caused by debris flows triggered by glacial advances on Yulong Mountain. • Fully investigated the paleo- damming chain sediments in the First Bend area of the Yangtze River. • OSL and 14C ages suggest that the river were dammed twice by debris flows during the ~20–7 and 1.5–0.4 ka period, and two outburst megafloods occurred at ~18–20 and ~ 6.0 ka, respectively. • The damming events were caused by debris flows triggered by glacial advances on Yulong Mountain. [ABSTRACT FROM AUTHOR]

The novel coronavirus disease 2019 (COVID-19) has spread globally and the meteorological factors vary greatly across the world. Understanding the effect of meteorological factors and control strategies on COVID-19 transmission is critical to contain the epidemic. Using individual-level data in mainland China, Hong Kong, and Singapore, and the number of confirmed cases in other regions, we explore the effect of temperature, relative humidity, and control measures on the spread of COVID-19. We find that high temperature mitigates the transmission of the disease. High relative humidity promotes COVID-19 transmission when temperature is low, but tends to reduce transmission when temperature is high. Implementing classical control measures can dramatically slow the spread of the disease. However, due to the occurrence of pre-symptomatic infections, the effect of the measures to shorten treatment time is markedly reduced and the importance of contact quarantine and social distancing increases., Competing Interests: Declaration of competing interest The authors declare that they have no conflict of interest., (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)

A longitudinal study of cotton workers was undertaken to assess the presence of work-related medical effects. A cohort of 110 subjects was examined before starting work and one year later. Measurements of pulmonary function were made before and after the work shift. Airway responsiveness was measured using a methacholine challenge test. A questionnaire was used to determine work-related symptoms. The 60 workers who remained after three years experienced an over-shift drop in FEV1 and an increase in airway responsiveness that did not increase after the first year. The data from the dropout group (n = 50) before work and after one year were compared with those for the active workers. The dropout group had a higher prevalence of symptoms of chest tightness and nasal irritation after one year of work. Atopy was not more common in this group. The results suggest that leaving work was related to symptoms of airways inflammation but not to atopy.