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Objective: Standard medical treatment for early non‐small cell lung cancer (NSCLC) is surgery; however, stereotactic body radiotherapy (SBRT) can be a viable substitute for elderly patients who can no longer tolerate or refuse surgery. The unsurpassed care for elderly patients with early NSCLC remains inconclusive. We conducted a propensity‐score matching analysis to compare the efficacy and side‐effects of SBRT and video‐assisted thoracic surgery (VATS) in elderly patients with pathologically‐proven early NSCLC. Methods: This single‐institution retrospective study included 310 elderly patients who underwent VATS (n = 180) or SBRT (n = 130) from January 2011 to November 2018 at the Tianjin Medical University Cancer Institute and Hospital. Sex, performance status, pathology type, Charlson Comorbidity Index, and T‐stage according to the eighth tumor node metastasis classification were considered when performing propensity‐score matching. Results: After propensity‐score matching, 71 patients were included in each group for analysis. A median follow‐up period of 53.5 months was observed for all patients; 72 and 53 months for patients undergoing VATS and SBRT, respectively. Overall survival (p = 0.492), progression‐free survival (p = 0.294), locoregional recurrence‐free survival (p = 0.866), and distant metastasis‐free survival (p = 0.452) did not differ significantly between the VATS and SBRT groups. Multivariate analysis showed a significant correlation between the T‐stage and overall survival. However, treatment‐related toxicity was lower in the SBRT group than in the VATS group. Conclusions: SBRT is an option comparable with surgery for elderly patients with pathologically‐proven early‐stage NSCLC. [ABSTRACT FROM AUTHOR]

Paragonimus proliferus, a lung fluke of the genus Paragonimus, was first reported in Yunnan province, China. P. proliferus can infect Sprague-Dawley (SD) rats and cause lung damage, but there is still no direct evidence of human infection. Until now, there has been a lack of studies on P. proliferus parasitism and development in mammalian lung tissue. The aim of this study was to perform transcriptomic profiling of P. proliferus at different developmental stages. SD rats were infected with P. proliferus metacercariae obtained from crabs; worms isolated from the lungs at different time points as well as metacercariae were subjected to whole transcriptome sequencing. Overall, 34,403 transcripts with the total length of 33,223,828 bp, average length of 965 bp, and N50 of 1833 bp were assembled. Comparative analysis indicated that P. proliferus, similar to other Paragonimus spp., expressed genes related to catabolism, whereas P. proliferus-specific transcripts were related to the maintenance of cellular redox homeostasis, sensitivity to bacteria, and immune response. Transcriptional dynamics analysis revealed that genes involved in the regulation of catabolism and apoptosis had stable expression over the P. proliferus life cycle, whereas those involved in development and immune response showed time-dependent changes. High expression of genes associated with immune response corresponded to that of genes regulating the sensitivity to bacteria and immune protection. We constructed a P. proliferus developmental model, including the development of the body, suckers, blood cells, reproductive and tracheal systems, lymph, skin, cartilage, and other tissues and organs, and an immune response model, which mainly involved T cells and macrophages. Our study provides a foundation for further research into the molecular biology and infection mechanism of P. proliferus. [ABSTRACT FROM AUTHOR]

By implementing the scientific development outlook and studying the essence of the 17th and l8th Congresses of CPC, it is proposed that economic construction should come first, and coordinative construction should be applied to ease the main social contradiction and to promote the building of socialism with Chinese characteristics. The necessity is pointed out for the change of focus on economic construction to the "focus on coordinative construction of economy, politics, culture, society, ecological civilization and scientific technology", which is commonly recognized as being helpful to the actualization of "Chinese Dreams". [ABSTRACT FROM AUTHOR]

Composition of genetically modified (GM) rapeseed events in Shanghai port was identified among 27 lots of rapeseed samples imported from Canada and Ukraine. Event - specific real - time PCR methods suitable for known GM rapeseeds RT73, T45, Oxy235, Topasl9/2, MS1 x RF1, MS1 x RF2 and MS8 x RF3 were employed in this study. Results showed that 25 lots of rapeseeds, accounting for 92. 6% of total, were positive by detection of the exogenous gene bar, PAT, GOX and NPTII. GM rapeseeds RT73 and MS8 x RF3 were detected in all 25 positive lots, indicating that they were the major imported rapeseed events. MS1 x RF1 and MS1 x RF2 events could be detected in 40% lots. T45, Oxy235 and Topas19/2 could be detected in a few lots. The results indicated that all the seven GM rapeseed events licensed by the Ministry of Agriculture of People's Republic of China existed in imported rapeseed samples in Shanghai port. [ABSTRACT FROM AUTHOR]

Exploring the spatiotemporal variations and response characteristics of global vegetation and extreme climate is of great significance for addressing global climate change and improving ecosystem stability. Based on ERA5 climate data from the European Centre for Medium-Range Weather Forecasts and MODIS normalized difference vegetation index (NDVI) data, we used Sen's trend analysis, correlation analysis, and random forest regression model to explore the responses of NDVI of five vegetation types (boreal and temperate forest, tropical forest, other woody vegetation, grassland, and cropland) to 23 extreme climate indices from 2001 to 2020. The results showed that global NDVI showed an overall increasing trend from 2001 to 2020. The areas with the most significant growth trend was boreal and temperate forest, and the least significant growth trend occurred in cropland. In terms of extreme climate index, except for a few extreme high temperature and low temperature indices, the other indices showed an increasing trend. Across different vegetation areas, the extreme climate index that had the greatest influence on NDVI was different. The results of correlation analysis showed that the indices with the greatest impact on NDVI in the boreal and temperate forest, tropical forest, other woody vegetation, grassland, and cropland were cold days, ice days, annual total precipitation, annual total precipitation, and annual total precipitation, respectively. The results of random forest analysis showed that the indices with the greatest impact on NDVI in each vegetation zone were cold days, warm night days, frost days, warm days, and the cold spell duration index, respectively. The reason for the different results between the two methods was that correlation analysis only reflected linear relationships between variables, while the random forest regression model could capture more complex nonlinear relationships. Our results showed that the response of global vegetation to extreme climate had significant regional differences and complexities, which may result from interactions between different climate factors.

To systematically evaluate the effects of comprehensive nursing interventions on wound pain and complications in patients after tonsillectomy, with a view to providing a reference basis for future post-tonsillectomy care. According to the developed literature search strategy, PubMed, Web of Science, Cochrane Library, Embase, Wanfang, China Biomedical Literature Database and China National Knowledge Infrastructure database were systematically searched, from database inception to October 2023, for randomised controlled trials (RCTs) of the application of comprehensive nursing interventions in patients undergoing tonsillectomy. Two researchers independently screened the literature, evaluated the risk of bias of the included studies and extracted data in strict accordance with the inclusion and exclusion criteria. RevMan 5.4 software was applied for data analysis. Overall, 18 RCTs involving 1954 patients were included, including 967 in the comprehensive nursing group and 987 in the conventional nursing group. The analyses revealed that compared with conventional nursing, patients who received comprehensive nursing interventions had lower postoperative wound pain scores (standardised mean difference [SMD]: -2.30, 95% confidence interval [CI]: -2.19 to -1.70, p < 0.00001), shorter hospital stays (SMD: -1.95, 95% CI: -2.39 to -1.51, p < 0.00001), incidence of postoperative haemorrhage (1.60% vs. 6.41%, odds ratio [OR]: 0.29, 95% CI: 0.12-0.70, p = 0.006) and complication rates (4.21% vs. 19.01%, OR: 0.19, 95% CI: 0.11-0.32, p < 0.00001) was lower. This study concludes as follows: comprehensive nursing intervention applied to tonsillectomy can significantly reduce patients' postoperative wound pain, shorten hospital stay, reduce postoperative bleeding and postoperative complications, which is worthy of being promoted and applied in the clinic., (© 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.)