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How the financial structure promotes the development of real economy has always been a research topic in academia. By analyzing the characteristics of China's financial system, this paper constructs the Finance Structure Index (FSI) from the perspectives of structural efficiency, financing structure and industry structure, and interprets the trend of the FSI. Based on the quarterly data of China from 2004 to 2020, this paper constructs a time-varying parameter-vector autoregression (TVP-VAR) model to study the dynamic impact of finance structure on the growth and optimization of the structure of the real economy. The empirical analysis results show that the response of the real economy has time-varying characteristics. Early on, financial structure has a promotion effect on the scale of the real economy, but the impact on the structure is not clear. In the middle, the effect of promoting the scale decreases slightly and then rebounds rapidly, while the optimization of the structure is inhibited. Later, it has a significant promoting effect and an obvious time-lag effect. Moreover, the impact of the financial structure is unstable. It is necessary to improve the efficiency and quality of the transmission of the optimization of the financial structure to the real economy. [ABSTRACT FROM AUTHOR]

Common carp (Cyprinus carpio L.) is one of the most widely cultivated fish in China. Spring viraemia of carp virus (SVCV) is a highly pathogenic virus and has often caused excessive losses in carp pond fisheries. Innate immune play important roles against virus infection. To better understand the immune response of common carp against SVCV infection, transcriptome analysis was performed using the Illumina Novaseq 6000 platform. It was showed that a total of 3953 differentially expressed unigenes were identified, and the RLR signaling pathway were significantly enriched after SVCV infection. Subsequently, the role of RLR signaling pathway in SVCV infection was studied. The results showed that common carp RIG-I (Cc RIG-I) and TRIM25 (Cc TRIM25) significantly decreased the replication of SVCV by inducing the phosphorylation of TBK1, IRF3 and p65 and the expression of ifn-1 , viperin , isg15 and mx. Further studies illustrated that Cc TRIM25 could positive regulate Cc RIG-I mediated downstream signaling pathway. Finally, the mechanism of Cc TRIM25 promoting Cc RIG-I-mediated signaling was investigated. Cc TRIM25 could interact with the caspase activation and recruitment domain (CARD) of Cc RIG-I and promoted K63-linked polyubiquitination of Cc RIG-I. Altogether, the study revealed a mechanism of Cc TRIM25 regulating Cc RIG-I mediated immune response in SVCV infection. • Comparative transcriptome analysis of common carp was performed with and without SVCV-infected. • RLRs signaling pathway were significantly enriched. • Cc RIG-I and Cc TRIM25 participated in immune processes against SVCV infection. • Cc TRIM25 positively regulated Cc RIG-I mediated signal pathway through promoting its K63-linked polyubiquitination. [ABSTRACT FROM AUTHOR]