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This study conducted a nationwide specific assessment of soil chromium (Cr) contamination status in 506 of China's industrial regions. The overall soil Cr concentrations were 0.74–37,967.33 mg/kg, and the soil Cr content in 4.15% of the regions exceeded the reference screening value (2500 mg/kg). Geochemical accumulation index (Igeo) and monomial potential ecological risk index (E) revealed Cr salt production and tanning were the primary control industries. The non-carcinogenic risks posed by Cr salt production and tanning industries were higher than the national average values, and children were the most vulnerable groups. The heavily polluted regions were mainly located at the Yangtze River Delta, the Bohai Rim, the Pearl River Delta, the Yangtze River Basin, and the Yellow River Basin. The Yangtze River Delta was further identified as the high priority control area based on the class distribution of Igeo and E. Regression analysis showed the soil Cr concentrations in industrial regions increased during 2002–2009 and then turned into a declining trend in 2009–2021. This paper gives detailed insights into soil Cr pollution status in industrial regions across China and the results may serve as references for formulating tailored control measures for different industries and areas. [ABSTRACT FROM AUTHOR]

Autonomous detection and fishing by underwater robots will be the main way to obtain aquatic products in the future; sea urchins are the main research object of aquatic product detection. When the classical Single-Shot MultiBox Detector (SSD) algorithm is applied to the detection of sea urchins, it also has disadvantages of being inaccurate to small targets and insensitive to the direction of the sea urchin. Based on the classic SSD algorithm, this paper proposes a feature-enhanced sea urchin detection algorithm. Firstly, according to the spiny-edge characteristics of a sea urchin, a multidirectional edge detection algorithm is proposed to enhance the feature, which is taken as the 4th channel of image and the original 3 channels of underwater image together as the input for the further deep learning. Then, in order to improve the shortcomings of SSD algorithm's poor ability to detect small targets, resnet 50 is used as the basic framework of the network, and the idea of feature cross-level fusion is adopted to improve the feature expression ability and strengthen semantic information. The open data set provided by the National Natural Science Foundation of China underwater Robot Competition will be used as the test set and training set. Under the same training and test conditions, the AP value of the algorithm in this paper reaches 81.0%, 7.6% higher than the classic SSD algorithm, and the confidence of small target analysis is also improved. Experimental results show that the algorithm in this paper can effectively improve the accuracy of sea urchin detection. [ABSTRACT FROM AUTHOR]

Comprehensive governance of the watershed environment is one of the keys to urban and regional development and construction, which will affect not only the overall quality of urban economic development, but also the production and lives of urban residents. Since the economy in the Yangtze River Delta develops rapidly and the water environmental issues is more and more striking, it is in urgent need of moving forward the governance of water environment. This study empirically analyzes the governance efficiency of water environment in the Yangtze River Delta from 2006 to 2017 adopting the methods of the DPSIR (Driving Force-Pressure-State-Impact-Response Analysis model)-TOPSIS (Technique for Order Preference by Similarity to an Ideal Solution) and the SNA (Social Network Analysis) to clarify the roles and responsibilities of different cities and main contributors in the governance of water environment. According to the research, the following results are attained: first, due to the effects of pressure and the state subsystem, the Yangtze River Delta's governance efficiency of water environment has increased steadily over time, from 0.3704 in 2006 to 0.4645 in 2017, but the disparities across cities have further widened. Second, in terms of contributors, the enterprises and governments play the main roles in the governance of water environment in recent years, while the public cannot always exert significant influence owing to unexpected environmental occurrences. Lastly, from the perspective of regional coordinated governance, the Yangtze River Delta resembles a tightly connected network of collaborative governance of water environment, with network connectivity and density growing year after year. However, the network structure of the governance efficiency of water environment in the study area is asymmetric, and network connectivity is higher inside the administrative regions, whereas spatial connectivity across provincial administrative boundaries has to be improved. The research scale and connotation in the field of the governance of water environment can be expanded and deepened through the study on the evaluation of the governance efficiency of water environment in the Yangtze River Delta, and it has considerable practical implications in modernizing the national governance system and capability.

Objective: To explore the clinical features and genetic basis for a Chinese pedigree diagnosed with congenital glycosylation disease (CGD)., Methods: Clinical manifestations of two brothers were analyzed. Whole exome sequencing was carried out for the sib pair. Suspected variants were verified by Sanger sequencing., Results: Both the proband and her younger brother were found to carry compound heterozygous variants of the PMM2 gene, which included a known pathogenic mutation of c.395T>C (p.I132T) and a previously unreported c.448-1(delAG) in the 5' end of exon 6 of the gene., Conclusion: The compound heterozygous variants of the PMM2 gene probably underlay the CGD in the sib pair.

Background: Leuprorelin is an analog of gonadotropin-releasing hormone that is used for the therapy of central precocious puberty (CPP). The aims of this prospective, open label, multicenter clinical trial were to establish its efficacy and safety during long-term use., Methods: Patients, who were all children, were treated with 1.88 to 3.75 mg leuprorelin subcutaneously once every 4 weeks for a total of 96 weeks between 2015 and 2018. The primary endpoint was the rate of occurrence of adverse events (AEs) and the secondary endpoint was no progression in the Tanner stage or regression by week 96 compared to baseline., Results: A total of 307 CPP patients, 305 (99.3%) females and 2 males (0.7%), completed the 96-weeks of treatment. Due to limited data for male patients, they are not discussed in the efficacy results. Treatment-emergent AEs (TEAEs) were reported for 252 (82.1%) patients, mostly (79.5%) being mild or moderate and only 33 (10.7%) of patients experienced TEAEs related to leuprorelin therapy. The most frequent (>2%) drug-related TEAEs were injection site induration (4.6%, 14/307) and vaginal bleeding (2.3%, 7/305). After treatment, 83.5% of patients had regression or no progression in the Tanner stage (95% confidence interval: 78.68%, 87.62%) and the majority had decreased gonadotropin-releasing hormone-stimulated peak luteinizing hormone and follicle-stimulating hormone concentrations, as well as reduced sex hormone concentrations and a reduction in the bone age/chronological age ratio compared to baseline., Conclusions: The trial revealed that CPP was effectively treated in most patients who received leuprorelin for nearly 2 years. Any drug-related AEs were reported with low incidence (<5%) and were consistent with the known safety profile of leuprorelin., Trial Registration: The trial was registered at ClinicalTrials.gov (registration number: NCT02427958)., Competing Interests: All remaining authors declare that there are no conflicts of interest that could be perceived as prejudicing the impartiality of the research reported., (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)