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With the rapid economic development in China, coal resources are being exploited greatly, which easily causes geological disasters due to surface subsidence. Fast and accurate surface subsidence monitoring and forecasting in mining regions are important references to analyze surface variation laws and disaster warning. However, differential interferometric synthetic aperture radar (D-InSAR) in mine surface monitoring is highly sensitive to spatiotemporal baseline and atmospheric delay. In addition, traditional machine learning algorithms have complicated network structures and difficulties determining parameters. Small baseline subsets InSAR (SBAS-InSAR) and extreme learning machine (ELM) dynamic prediction were combined for corresponding experimental studies to address these problems. On the basis of SBAS-InSAR, surface subsidence monitoring data in mining areas in Pingdingshan City, China, were collected, and a comparative analysis of D-InSAR monitoring data was performed, which verified the validity of SBAS-InSAR monitoring. On the basis of SBAS-InSAR data, a prediction model was built by ELM. The model results were compared with the prediction results of back propagation (BP) neural network and support vector machine (SVM) through root mean square error (RMSE) and mean relative error (MRE). Results demonstrate that the surface subsidence prediction of SBAS-InSAR in the monitoring mining area can reach millimeter accuracy. The MRE values of ELM, BP, and SVM prediction are maintained within 2%, 5%, and 8%, and the RMSE values are less than 3 mm, 7 mm, and 10 mm, respectively, thereby indicating that ELM prediction has high accuracy and reliability. This study provides an important evidence for safe production and scientific disaster prevention and reduction in mining areas. [ABSTRACT FROM AUTHOR]

Context: Up to 40% of patients with polycystic ovary syndrome (PCOS) have prediabetes; an optimal pharmacotherapy regimen for diabetes prevention in PCOS is yet to be established.Objective: To evaluate clinical efficacy of exenatide (EX), metformin (MET), or combination (COM) for prediabetes in PCOS.Design: Randomized, open-label, parallel-group controlled trial.Setting: Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine.Patients: PCOS with prediabetes (fasting plasma glucose 5.6-6.9 mmol/L and/or 2 hour post glucose 7.8-11.0 mmol/L on oral glucose tolerance test [OGTT]). A total of 150 out of 183 eligible enrollees completed the study.Intervention: EX (10-20μg daily), MET (1500-2000 mg daily), or COM (EX plus MET) for 12 weeks.Main Outcome Measures: Sustained remission rate of prediabetes (primary endpoint, a normal OGTT after 12 weeks of treatment followed by 12 weeks of washout on no drug treatment) along with anthropometric, hormonal, metabolic, and pancreatic β-cell function parameters (secondary endpoints) and potential mechanisms were assessed.Results: Impaired glucose tolerance was found the dominant prediabetes phenotype. Overall sustained prediabetes remission rate was 50.7%. Remission rate of COM group (64%, 32/50) or EX group (56%, 28/50) was significantly higher than that of the MET group (32%, 16/50) (P = .003 and .027, respectively). EX was associated with superior suppression of 2-hour glucose increment in OGTT. A 2-step hyperglycemic clamp study revealed that EX had led to higher postprandial insulin secretion than MET, potentially explaining the higher remission rate.Conclusions: Compared with MET monotherapy, EX or COM achieved higher rate of remission of prediabetes among PCOS patients by improving postprandial insulin secretion. [ABSTRACT FROM AUTHOR]

Based on the theoretical and clinical development of modern medicines, gene therapy has been a promising treatment strategy for cancer and other diseases. The practice of gene therapy is nearly 27 years old, since the first authorized gene transfer study took place at the National Institute of Health in 1989. However, gene therapy was not readily adopted worldwide, until recently. Several gene therapy clinical trials have been carried out in China since 1998, and medical research in China has flourished. In this report, we review the history of gene therapy in China, focusing on treatment protocol, the administration cycle, dosage calculation, and the evaluation of therapeutic effects, in order to provide more information for the additional development of this promising treatment strategy. [ABSTRACT FROM AUTHOR]

China's listed firms report substantial non-operating revenues and expenses. We argue that these non-core earnings should have different properties and different valuation implications than operating or core earnings. Furthermore, the different types of firm ownership may have differential impacts on the information content of earnings components. Based on data from 1996 to 2008, we find that core earnings are more persistent than non-core earnings. Because of this, core earnings have a greater association with contemporaneous stock returns. However, the stock market does not fully incorporate all the information in earnings; we find that core earnings are undervalued and non-core earnings are overvalued. This effect is much reduced for privately controlled listed firms. We develop an investment trading strategy to exploit these market inefficiencies. [ABSTRACT FROM PUBLISHER]

Objective: The goal of this study was to investigate whether vitamin A combined with iron supplementation for preschool children resulted in improved changes in children's infectious morbidity. Method: In this randomized placebo-controlled and blinded field intervention trial, totally 445 preschoolers, ages 3 to 6 y old, were randomly selected. All children were randomly divided into four groups: vitamin A supplement-only group (group I), iron supplement-only group (group II), vitamin A and iron supplement group (group III), and no vitamin A and ferrous sulfate as placebo-control (group IV) for 6 mo. The morbidity of diarrhea and respiratory infections, were collected during supplementation. Results: There was evidence of the lowest incidence rate of respiratory-related illnesses and fewest symptoms of runny nose, cough, and fever for children in group III compared with children in groups I, II and IV (P < 0.05). Moreover, despite the undistinguished incidence rate of vomiting, nausea, and stomach pain, the rate of diarrhea-related illness was significantly lower for children in group III than for those in the other three groups. Conclusion: The beneficial affects on infectious morbidity over 6 mo, highlight the potential of vitamin A plus an iron supplement for preschool-aged children. [ABSTRACT FROM AUTHOR]