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Purpose: To compare the efficacy and safety between traditional lens fitting and computer-aided fitting methods for orthokeratology (OrthoK) in the Chinese population., Methods: A multi-center, examiner-masked, randomized controlled study was conducted with a one-year follow-up period, enrolling 280 participants with spherical equivalent (SE) ranging from -0.5D to -4.0D. Participants were assigned to either the computer-aided orthokeratology fitting group (trial group) or the traditional lens fitting group (control group) using stratified randomization based on age (8 to 13 years, 13 to 18 years, and ≥ 18 years) to ensure a minimum of 30 cases in each sub-age group. Ocular examinations included visual acuity, objective and subjective refraction, corneal endothelial cell density, corneal topography, intraocular pressure, axial length, and ocular health assessment. Successful lens-correction was defined as the residual refraction with the OK lens, which should not exceed ± 0.5D, and/or an uncorrected visual acuity of no worse than 0.1 logMAR. Statistical analysis involves t-tests, analysis of variance, and Chi-squared tests., Results: 215 subjects were included in the statistical analysis (109 in the trial group and 106 in the control group). In both groups, compared to baseline data, the uncorrected visual acuity (UCVA) improved significantly, with SE reduced and central corneal curvature flattened greatly after wearing OrthoK lens (P < 0.05 for all). Compared to the control group, the trial group exhibited a higher successful rate in correcting UCVA (93.6 % vs. 84.0 %, P = 0.03) and slightly better correction in refraction (77.1 % vs. 66.0 %, P = 0.07) at 1-month follow-up. However, no significant differences were observed in the axial length elongation, corneal changes, or the incidence of adverse events between the two groups., Conclusion: These findings indicate the higher efficiency and slightly better performance in correcting myopia and improving UCVA of computer-aided lens fitting approach compared to the traditional one, but similar outcomes in controlling axial elongation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier Ltd.)

Background: Left bundle branch area pacing (LBBaP) is accepted as a physiological form of pacing; however, it is complex and usually requires an expensive electrophysiological recording system., Methods: A simplified approach ("9-partition method") was explored to perform LBBaP. In this method, a right anterior oblique 30° fluoroscopic image of the ventricle was divided into 9 sections ("3 × 3" partitions). From May 2018 to February 2019, we enrolled 51 consecutive patients who underwent pacemaker implantation. The patients were nonrandomly allocated to either the conventional LBBaP (c-LBBaP) group or simplified LBBaP (s-LBBaP) group., Results: The mean age was 68.53 ± 11.90 years, and 32 (62.7%) patients were male. The overall success rate was 90.2% (46/51). Compared with the c-LBBaP group, the s-LBBaP group had a significantly lower total procedure duration (91.57 ± 19.51 minutes vs 70.68 ± 13.26 minutes; P < 0.001) and fluoroscopy duration (16.52 ± 5.34 minutes vs 10.54 ± 3.13 minutes; P < 0.001). The time from the 3830 lead and sheath passage through the tricuspid valve to an acceptable initial fixation site (4.69 ± 1.61 minutes vs 2.75 ± 1.04 minutes; P < 0.001) and the time to the left bundle branch lead being implanted successfully (11.78 ± 3.00 minutes vs 7.67 ± 2.45 minutes; P < 0.001) for the c-LBBaP vs s-LBBaP groups, respectively, were significantly different. After 3 months, there were no significant differences in the capture threshold, R wave amplitude, impedance, or QRS duration between the groups., Conclusions: Compared with the c-LBBaP approach, our simplified 9-partition method was faster and did not require an expensive electrophysiological recording system., (Copyright © 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.)

Purpose: The objective of this study was to measure resected surfaces of the medial tibial plateau and to provide accurate anatomical parameters for the Chinese population and improve the unicompartmental knee arthroplasty (UKA) component design in the future., Methods: This study measured different dimensions of the medial tibial plateau on MRIs of 1000 consecutive healthy Chinese people without knee deformity. The anteroposterior (AP) dimension and mediolateral dimensions at defined points (recorded as WA, WB, WC) of the medial tibial plateau were measured. The aspect ratio (WB/AP, recorded as AR) was also recorded. The measured results were grouped to compare with the dimensions of the Oxford Phase III tibial component. An independent t test was used to compare the differences between the males and females., Results: The Oxford Phase III tibial component showed mediolateral overhang or undersize for the whole range of measured anteroposterior dimensions of the resected medial tibial plateau. A total of 71.3% patients' resected surface did not match the Oxford Phase III tibial component well. The study also found a decrease in the aspect ratio (WB/AP) with an increase in the AP dimension in the medial tibial plateau., Conclusions: There is a difference between the morphology of the Chinese knee joint and the configuration of the Oxford Phase III tibial components. The results of this study provided accurate anatomical parameters for Chinese and guidelines for designing UKA components suitable for the Chinese population., Level of Evidence: Retrospective comparative study, Level III.

Objective: To identify the optimal femoral intramedullary rod insertion depth and direction on the sagittal plane in total knee arthroplasty (TKA) of Chinese osteoarthritis (OA) patients., Methods: From January to December 2019, CT data were collected for 85 consecutive entire lower extremity Chinese OA patients. A three-dimensional method was used to simulate intramedullary rod penetration. The intramedullary rods were inserted toward the anterior (TA), center (TC), and posterior (TP) of the femoral canal, respectively. Four penetration depths of 150, 200, 250, and 300 mm from the joint line were set. The intersection angle was measured between the simulated intramedullary rod and the mechanical axis of the femur (FMA) on the sagittal plane., Results: Our study included 85 Chinese OA patients: 46 women, with a mean age of 65.7 ± 8.4 years (range, 51-85 years) and 39 men, with a mean age of 65.6 ± 8.1 years (range, 46-86 years). The intersection angle between the FMA and the femoral anatomical axis was smaller in men, 2.4° ± 1.6° (range, 0°-4.8°), than in women, 3.5° ± 2.3° (range, 0.7º-8.2°), with a significant statistical difference (P < 0.01). In the comparison of the intersection angle between the simulated intramedullary rod and the FMA, there was no statistical difference between TA200 and TC200 in women (P > 0.05). The proportions were up to 91% and 96% of TA200 at 0°-3° and 0°-5° intervals, respectively, but just 63% and 78% in TC200. In TA150, 76% of intersection angles were greater than 5°. Only approximately 60% in TA250 and TA300 were within the 0°-5° interval and 40% were less than 0°. Only 57% of intersection angles in TC150 were in the 0°-3° interval. TC250, TC300, and TP150 were mostly below 0°. In men, there were statistical differences between all groups. All intersection angles were greater than 5° in TA150. TA200 and TA250 were mostly greater than 5° (87% and 59%, respectively) and 72% of intersection angles were within 0°-5° interval in TA300. TC150 had 92% of intersection angles within the 0°-5° interval but only 62% between the 0° and 3° interval. In the TC200, up to 90% and 97% were within 0°-3° and 0°-5° intervals, respectively. TC300, TP150, and TP200 were mostly below 0°., Conclusion: We described an innovative method for rapidly, simply, and accurately identifying the sagittal insertion depth and direction of the femoral intramedullary rod in TKA, which can optimize the position of the femoral prosthetic component on the sagittal plane in TKA., (© 2020 The Authors. Orthopaedic Surgery published by Chinese Orthopaedic Association and John Wiley & Sons Australia, Ltd.)

Purpose: To investigate the effectiveness, safety and tolerance of rigid gas-permeable contact lenses (RGP CLs) in the visual rehabilitation of unilateral aphakic children in China., Methods: Records of 36 children (36 eyes) with RGP CLs to unilateral aphakia between 2014 and 2018 were evaluated. Each enrolled child underwent vision assessment (visual acuity, fixation, and deviation) at each follow-up visit and their caregivers completed a questionnaire designed to find out the reasons for RGP CLs dropout. The fit characteristics and adverse events were also evaluated., Results: The mean age was 7.0 months (interquartile range, 5.0-12.8 months). The final mean logMAR visual acuity (VA) of the treated eyes was 1.2 ± 0.7 for 12 patients who cooperated in visual assessments and 6 out of these subjects had a VA of better than 1.0 logMAR. The proportion of treated eyes which could be recorded the visual results increased significantly after RGP CLs intervention (5.6% vs. 33.3%, P < 0.001). The final VA assessed for the fellow eyes and both eyes were 0.7 ± 0.4 and 0.6 ± 0.3, respectively. Of the 36 patients, 24 had strabismus. There was no severe lens-related adverse event except only one patient had mild conjunctivitis. At the end of the follow-up it was found that 25 eyes are still using RGP CLs (69%). Indications to discontinue contact lens wear included difficult manipulation of RGP CL, loss of motivation, unstable lens, and eye irritation., Conclusions: RGP contact lenses provide an effective and safe alternative method for visual rehabilitation and can be well tolerated in pediatric aphakia., (Copyright © 2018. Published by Elsevier Ltd.)

Background: The aim was to evaluate the effect of ocular topography on soft contact lens fit in Chinese and Caucasians., Method: This study evaluated 547 subjects from two ethnic groups, Caucasian (n = 250) and Chinese (n = 297), at investigational sites in three locations: Wenzhou, China, Melbourne, Australia and Jacksonville, USA. Subjects underwent measurement of a range of ocular topographic variables using identical equipment and protocols, including: apical corneal radius (CR), corneal shape factor (CSF) in the two principal meridians, horizontal visible iris diameter (HVID), vertical palpebral aperture (PA), upper lid angle (ULA) and inter-canthal angle (ICA). Subjects were fitted with a spherical lens in two base curves (BCs) (1·Day ACUVUE, 8.50, 9.00 mm) and a toric soft lens (Accelerated Stabilization Design)., Results: The steeper base curve (8.50 mm) spherical lenses gave an acceptable overall lens fit with 98 per cent or more of subjects in both groups, while the flatter lens (9.00 mm) was acceptable in a significantly higher proportion of the Chinese compared to Caucasian group (96 versus 82 per cent, p < 0.0001) . The main difference in fit between groups was for centration; there was significantly less decentration with the Chinese group (8.50 BC: 39 versus 72 per cent, p < 0.0001; 9.0 BC: 63 versus. 85 per cent, p = 0.02). The 8.5 mm base curve showed good centration (none or slight decentration) for 97 per cent of Caucasian eyes and 96 per cent of Chinese eyes. With both groups, there were some significant correlations between lens fit and ocular topographic variables, most notable between upper lid angle and toric lens orientation with the Chinese subjects. Regression analysis also showed key predictive values relating to lens fit., Conclusions: Detailed ocular measurements suggest anatomical differences between Chinese and Caucasian populations that should be considered in soft lens design. The spherical and toric lenses tested in this study fitted a large proportion of both Chinese and Caucasian eyes and are robust to the ocular differences noted., (© 2016 Optometry Australia.)

Purpose: To evaluate eyelid and eye contour factors that can influence the fitting of toric soft contact lenses (TSCLs)., Methods: Thirty-two subjects (64 eyes) were enrolled and fitted with Lo-Torque design TSCLs. One eye of each subject was randomly selected. High-resolution digital images were acquired after the subjects had worn the lens for 20 minutes, and the images were then processed with Adobe Photoshop. The palpebral aperture (PA), various angles of the eyelid, horizontal visible iris diameter (HVID), and lens parameters were obtained. Finally, lens fitting was evaluated., Results: During the assessment of the correlations between the eyelid and eye contour factors and the lens fitting, there were four pairs of significant correlations: (1) the PA and rotational direction of the lens: larger eye PA was associated with a greater possibility of nasal rotation of the corresponding lens (P=0.03); (2) the angle of the central lower lid (θ3) and the rotational stability of the lens: the larger the angle was, the worse the rotational stability was (P=0.02); (3) the lower lid angle of the medial canthus (θ5) and temporal rotational recovery: the smaller the angle was, the more quickly the lens recovered (P=0.05); and (4) HVID and routine fitting assessments: the larger the HVID was, the looser the lens fitting (P=0.00). Finally, when assessing correlations between some lens parameters and the orientation of the lens, we found that lower sphere values were associated with quicker lens recovery (P=0.04)., Conclusion: Several eye factors, as well as lens characteristics, had impacts on the TSCLs fitting, including the PA, the angle of the central lower lid (θ3), the lower lid angle of the medial canthus (θ5), and the sphere of the lens. These factors should receive particular attention when fitting TSCLs.

Background: Femoral component overhang has been observed in total knee arthroplasty with different prostheses. The purpose of this study is to assess gender-based anatomical differences of the distal femur and femoral trochlea in the Chinese population and analyze the risk sites of femoral component overhang in relation to any significant anatomical differences., Methods: Measurements of distal condylar and femoral trochlea were made through three-dimensional computed tomographic modeling of 200 normal Chinese knees; the anatomical differences between genders and its relations to the femoral component overhang were analyzed. Four implants were also measured and compared., Results: The ML/AP ratios of the femoral condyles showed statistically significant gender-based variation (Men:Women=1.06:1.03, P<0.0001). Both the proximal and distal ML widths of the trochlea were generally larger in the men than those of the women. Regression analysis of the morphological data showed that as the measuring level moves distally along the femur, the coronal width deviation between genders progressively increases to peak at the distal condyles. Female subjects had a smaller aspect ratio than those of four implants and a smaller trochlear ML width than those of three implants., Conclusions: The males show significantly greater coronal dimensions of the trochlea than women which are likely to contribute to the higher prevalence of prosthetic overhang in women with some standard implants., Clinical Relevance: The overhang is most likely to occur in the distal femoral condyle and the distal region of the femoral trochlea when a standard knee prosthetic system is used in the Chinese women., (Copyright © 2012 Elsevier B.V. All rights reserved.)

The aim of this study was to compare the quality of fixed partial dentures (FPDs) made in a Chinese dental laboratory with corresponding FPDs made in Swedish dental laboratories. Twenty-one patients were fitted with FPDs between March 2007 and December 2008. Single crowns and prostheses of up to seven units were made. All dentures, gold and CoCr alloys covered with ceramic, were produced in duplicate: one by a dental technician in China and the other by a dental technician in Sweden. The dentures were blind-tested with regard to marginal integrity, anatomic form and color, approximal and occlusal contacts, and time taken for adjustments. The composition of dentures was analyzed, and the material used, framework weight, compliance of the laboratories, and costs (material and labour) were recorded. There was no difference in the quality of marginal integrity, anatomic form, color, approximal and occlusal contacts, or in the time taken for adjustments. The bridge frameworks made in China were thinner and lighter (p<0.01) than those made in Sweden. Three FPDs from China showed elastic deformation when tested clinically and were considered too thin for clinical use. In 11 out of 14 orders from the Chinese laboratory, the gold alloy specified was not delivered and the cobalt-chromium alloy contained small amounts (0.19%) of nickel.The prostheses with gold-alloy frameworks from China cost 47% of those from Sweden (p<0.01) and those with cobalt/chromium frameworks 44% (p<0.01). In conclusion, the quality of the FPDs made in Sweden and China was comparable, with the exception of the dimension of the Chinese bridges, which in some cases was considered too weak. The gold alloy ordered from the Chinese laboratory was often not the alloy delivered and the CoCr alloy contained small amounts of nickel. FPDs from China cost less than half the price of those from Sweden.

Objective: To evaluate the current pattern of lower-extremity amputation (LEA) in a Chinese population and to identify independent risk factors for failure to ambulate in the community after LEA., Design: Retrospective study., Setting: Tertiary hospital., Participants: Consecutive Chinese adults (N=189) who underwent LEA from 1995 to 1997., Interventions: Not applicable., Main Outcome Measures: Pattern of LEA in comparison with previous data and risk factors for failure to ambulate in the community after LEA., Results: The mean age at amputation was 74.1 years. Vascular occlusive disease and infection accounted for most of the reasons for the LEA. The pattern of LEA had changed significantly. The proportion of patients who were able to ambulate in the community decreased from 66.1% before the LEA to 29.9% 12 months after LEA. Logistic regression analysis showed that major amputation level, presence of diabetes mellitus, hypertension, inability to ambulate in the community before LEA, and failed use of prosthesis were significant independent risk factors for failure to ambulate in the community after LEA., Conclusions: A more aggressive rehabilitation approach, together with efforts targeted at various levels is required to achieve better functional ambulation level and to improve reintegration into the community after LEA.