1. Dietary exposure to mineral oil hydrocarbons of Chinese infants aged 0-6 months.
- Author
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Li, Min, Ying, Xuanyu, Yang, Chunyan, Li, Jianwen, Gao, Jie, Sui, Haixia, and Qian, Zhiyong
- Subjects
MINERAL oils ,FOOD combining ,INFANTS ,HEALTH risk assessment ,NUTRITION surveys ,INFANT formulas ,CARCINOGENS ,FOOD consumption - Abstract
Consumers are exposed to a range of mineral oil hydrocarbons (MOH) via food. The potential adverse health effect of MOH varies widely. Since infant formula (IF) is the major food source for infants, it is necessary to understand MOH exposure and consequent health impact. In the present study, occurrence data of 42 IF samples and food consumption data of 0–6 months infants from China National Food Consumption Survey in 2015 were linked to evaluate the dietary exposure to MOH of 0–6 months infants in China. Ordinary consumers (who purchased IF for 0–6 months infants in different packaging type randomly), packaging type loyal- and brand loyal-consumers were selected as three representative populations. For ordinary consumers and packaging-loyal consumers, dietary exposure to MOH was estimated both deterministically and probabilistically. For brand-loyal consumers, point-estimation was used as the exposure assessment method. Due to toxicological gaps for MOHs, it was inappropriate to derive health-based guidance value and perform the robust human health risk assessment. MOE approach was used to characterise MOSH risk. The no-observed-adverse-effect level for induction of liver microgranulomas, 19 mg/kg BW per day, was used as a reference point for calculating margins of exposure (MOEs) for MOSH exposure. Although first exposure occurs in babies, there are no relevant toxicology studies. All MOE values for different scenarios were higher than 100. There are no dose-response data on the carcinogenicity of MOAH mixtures and hence it is not possible to establish a reference point to calculate the MOE and characterise its risk. Therefore, it is not possible to draw conclusions about the full nature of possible concerns for infants aged 0–6 months. This study evaluates by a probabilistic approach the dietary intake of Chinese infants aged 0–6 months to MOH for the first time and describes the associated uncertainties. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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