1. In vitro synergistic effects of fisetin and norfloxacin against aquatic isolates of Serratia marcescens.
- Author
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Dong J, Ruan J, Xu N, Yang Y, and Ai X
- Subjects
- Animals, Aquatic Organisms isolation & purification, China, Flavonols, Microbial Sensitivity Tests, Serratia Infections microbiology, Serratia Infections veterinary, Serratia marcescens isolation & purification, Turtles, Anti-Bacterial Agents pharmacology, Aquatic Organisms drug effects, Drug Synergism, Flavonoids pharmacology, Norfloxacin pharmacology, Serratia marcescens drug effects
- Abstract
Serratia marcescens is a common pathogenic bacterium that can cause infections in both humans and animals. It can cause a range of diseases, from slight wound infections to life-threatening bacteraemia and pneumonia. The emergence of antimicrobial resistance has limited the treatment of the diseases caused by the bacterium to a great extent. Consequently, there is an urgent need to develop novel antimicrobial strategies against this pathogen. Synergistic strategy is a new approach to treat the infections caused by drug-resistant bacteria. In this paper, we isolated and identified the first multi-resistant pathogenic Serratia marcescens strain from diseased soft-shelled turtles (Pelodiscus sinensis) in China. We then performed a checkerboard assay; the results showed that out of 10 tested natural products fisetin had synergistic effects against S. marcescens when combined with norfloxacin. The time-kill curve assay further confirmed the results of the checkerboard assay. We found that this novel synergistic effect could significantly reduce the dosage of norfloxacin against S. marcescens., (© FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2016
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