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Sustainable development is a common development model pursued by countries around the world. The environmental, social, and governance (ESG) concept has garnered significant interest across industries globally. This study extends on existing research (Fang & Hu, 2023), from the perspective of innovation sustainability, and investigates the impact of ESG performance on enterprise sustainable green innovation (SGI). For the data of 1140 Chinese A‐share listed enterprises from 2009 to 2019, the estimated result shows that the coefficient of ESG performance is 0.6640 (p < 0.05). This means that ESG advantages significantly promote enterprise SGI. And the environmental dimension performance has a bigger promoting effect. The impact of ESG on SGI is significantly positive for growth and maturity stages, state‐owned, and non‐heavy pollution industry enterprises. Green investor and environmental subsidy are important ways for ESG performance to affect SGI. In addition, the executive environmental protection experience moderates the relationship between ESG performance and SGI in a significant and beneficial way. This study proposes that government agencies should implement differentiated ESG regulation measures and enterprises can increase their reliance on stakeholders and social resources to acquire additional resources. Theoretical and practical implications of this contribute to the enhancement of enterprise SGI. [ABSTRACT FROM AUTHOR]

Exploring enterprise carbon performance (ECP) via green capital allocation is important for achieving the dual carbon goal. In this article, the impact of the green credit policy (GCP) on ECP is empirically examined using a difference-in-differences model. The results show that GCP significantly improves ECP, and this conclusion remains valid after a series of robustness tests. Low-carbon technology and carbon information disclosure are central transmission mechanisms that are positively adjusted by green consumption, environmental regulation, and marketisation degree. Furthermore, state-owned and declining enterprises are affected more strongly by GCP than non-state-owned, growing, and mature enterprises. The impact of GCP on ECP increases over the enterprise life cycle. [ABSTRACT FROM AUTHOR]

Using panel data for 277 Chinese cities, this paper applies a time-varying difference-in-differences (DID) model to empirically test the impact of China's carbon emissions trading scheme (ETS) on urban air quality, and further explores its heterogeneity and the mechanisms involved. The results show that ETS can improve urban air quality. This conclusion remains robust through a series of robustness tests, including PSM-DID estimation, varying window periods, exclusion of significant events, lag phase, and placebo tests. The dynamic effect test indicates that ETS has a continuous and effective effect on improving urban air quality. Mechanism analysis reveals that the degree of marketization can enhance the improvement effect that ETS has on urban air quality. Meanwhile, industrial structure upgrading and green technology innovation are important mechanisms by which pilot ETS policy improves urban air quality. Regional heterogeneity analysis finds that ETS only improves urban air quality in eastern and central regions. [ABSTRACT FROM AUTHOR]

Regarding the goal of "carbon peaking and carbon neutrality," an urgent practical problem is how green finance decreases carbon emissions. This paper uses the dynamic spatial Durbin model and China's provincial panel data to empirically test the impact of green credit on carbon emissions. The results show that green credit effectively curbs carbon emissions, and has significant spatial spillover effects on the carbon emissions. In the short run, the spillover effects of green credit on carbon emissions are greater than the direct effects, but in the long run, the direct effects of green credit on carbon emissions are greater than the spillover effects. The mechanism test finds that upgrading industrial structure is an important transmission channel for green credit to affect carbon emissions, and energy consumption only plays a part of the intermediary role in the direct impact of green credit on carbon emissions. However, green credit has not achieved the goal of carbon emission reduction by promoting low-carbon technology innovation. [ABSTRACT FROM AUTHOR]

With the data of Chinese A-share-listed companies from 2004 to 2017, this paper builds a difference-in-differences model to investigate the impact of air pollution collaborative governance on green technology innovation. The main results show that air pollution collaborative governance promotes green technology innovation, and a series of robustness tests also verify this conclusion. Patent heterogeneity analysis suggests that air pollution collaborative governance increases the number of green utility model patents, but has no obvious impact on green invention patents. In terms of enterprise heterogeneity, air pollution collaborative governance can effectively stimulate the non-heavy-polluting enterprises to innovate green technology, but the incentive effect on heavy-polluting enterprises is not evident. Moreover, by constructing a mediating effect model and a moderating effect model, mechanism analysis reveals that R&D investment plays a positive mediating role in the impact of air pollution collaborative governance on green technology innovation, and the increase of government subsidy also enhances the promotion effect of air pollution collaborative governance on green technology innovation. [ABSTRACT FROM AUTHOR]

Objectives: Lobaplatin (LBP), a third-generation cisplatin derivative has shown promising activity and few side effects in oesophageal squamous cell carcinoma (ESCC) in previous reports. We compared LBP plus docetaxel with cisplatin plus docetaxel as adjuvant chemotherapy in ESCC patients to determine the effects on overall survival (OS) and toxicity. Methods: A multicentre retrospective study was performed using propensity score matching (PSM) with the Medicine-LinkDoc database. Patients diagnosed with stage II-III ESCC treated with adjuvant chemotherapy (cisplatin plus docetaxel or LBP plus docetaxel) between January 2013 and December 2016 were selected from 6 centres in China. Results: There were 733 eligible ESCC patients. After PSM (1:1 ratio), 458 patients remained. The 5-year OS rates of the cisplatin and LBP groups were 25.9% and 23.6%, respectively (P=0.457). Leukopenia (grade III-IV/I-II/0: 2.62%/34.5%/59.39% versus 5.24%/43.23%/45.85%; P=0.0176), neutropenia (grade III-IV/I-II/0: 6.55%/37.56%/51.09% versus 4.37%/53.28%/36.34%; P=0.0015), nephrotoxicity (grade I-II/0: 13.97%/76.86% versus 26.64%/65.94%; P<0.001) and gastrointestinal symptoms (grade III-IV/I-II/0: 2.18%/54.59%/32.31% versus 6.55%/65.07%/20.88%; P=0.0011) were more frequent in the cisplatin group. Conclusions: Compared with cisplatin plus docetaxel, LBP plus docetaxel provided the same survival benefits but lower side effects of myelosuppression and gastrointestinal symptoms. LBP plus docetaxel might be a choice for adjuvant chemotherapy in ESCC. Clinical Trial Registration: Lobaplatin or Cisplatin in Adjuvant Chemotherapy for Oesophageal Carcinoma, identifier NCT03413436. [ABSTRACT FROM AUTHOR]

Background: In China, open surgical approaches for esophageal cancer (EC) can be divided into two techniques, the right- and left- transthoracic esophagectomy. Although there is an increasing number of instances that use the right side, the optimal surgical technique remains unclear. Based in a large cancer center with rich experience of both transthoracic side approaches, this study compared the long-term survival of patients treated by these two surgical techniques. Methods: The patients included in this study underwent a right transthoracic esophagectomy (Right, McKeown) or left transthoracic esophagectomy (Left, Sweet, or chest neck dual-incision) for esophageal squamous cell carcinoma (ESCC) between January 2015 and October 2018. The overall survival(OS) rate and perioperative data between the two groups were then retrospectively analyzed. Results: We included 437 patients who underwent Right (n = 202) and Left (n = 235) approaches for ESCC. There was a significantly longer median operative time (250 vs. 190 min, P < 0.001) and longer median postoperative hospital stay (17 vs. 14 days, P < 0.001) in the Right side group. The OS at 5-years was 49.9% in the Right group and 52.45% in the Left group; hazard ratio (HR) (95% CI): 1.002 (0.752–1.337), p = 0.987. Conclusions: For middle thoracic ESCC without suspected lymph node metastasis in the upper mediastinum, the esophagectomy through the Left thoracic approach could achieve the same OS as the Right side, with better short-term outcomes. [ABSTRACT FROM AUTHOR]

Background: Fuyu city in China has a high prevalence of hepatitis C virus (HCV) infection resulting in a high morbidity and mortality from chronic liver disease and hepatocellular carcinoma. This study was conducted to identify the risk factors for HCV infection in Fuyu city.Methods: Recruitment of study subjects involved a cross-sectional survey using non-random, convenience sampling. Information on demographic variables, risk factors for HCV infection, clinical manifestations, behavioral practices and family history was collected by administering a questionnaire. Anti-HCV antibody was detected using Abbott ARCHITECT i2000SR. HCV infection was confirmed by HCV-RNA testing by the Roche Taqman HCV test. Univariate and multivariate analyses were performed to identify the factors associated with HCV infection.Results: Out of 3,228 persons that participated in the survey, 3,219 were enrolled in the study. The prevalence of HCV infection was 42.1 % (1355/3219). Among 734 patients with chronic HCV infection whose HCV-RNA genotyping was performed, genotype 1b was the most common (58.0 %), followed by genotype 2a (40.2 %), while co-infection with genotypes 1b and 2a was detected in 1.8 % of the subjects. On univariate analysis, male gender, older age, parenteral caffeinum natrio-benzoicum and share syringes (PCNBSS), and nine other factors were significantly associated with HCV infection. After adjusting for potential confounders, male gender, old age, cigarette smoking, lower education level, history of blood transfusion, blood donation, prior dental surgery, and PCNBSS were found to be independently associated with HCV infection.Conclusions: The prevalence of HCV infection is likely to be high among residents in Fuyu and we observed that genotypes 1b and 2a dominated in the city. Our findings support the hypothesis that PCNBSS which became endemic in Fuyu city during 1970s-1980s is strongly associated with HCV positivity. [ABSTRACT FROM AUTHOR]

HAdV-56 is a new recombinant type isolated from epidemic keratoconjunctivitis (EKC) patients and has been sporadically isolated in Japan several times. Here, an outbreak of EKC in the city of Dalian, China involving a large number of workers in two factories was reported; this was the first outbreak of EKC associated with HAdV-56 worldwide. [ABSTRACT FROM AUTHOR]

Breast cancer occurs earlier in Chinese women than in Caucasian women. We have compared the clinicopathologic characteristics and prognosis in very young and older premenopausal women with breast cancer in south China. We separated 905 consecutive premenopausal patients with first diagnosis of breast cancer, surgically treated at the Sun Yat-sen University Cancer Center from October 2003 to December 2006, into a very young group (189 [13.7%]; <35 years old) and an older group (716 [52.0%]; 35-57 years old). Approximately, 90% of patients received adjuvant chemotherapy and hormonal therapy with tamoxifen for hormone-receptor (HR)-positive breast cancer. We retrospectively compared the clinicopathologic factors and survival rates of these two groups. The 3-year disease-free survival rate (78.0% versus 89.1%, p < 0.001) was poorer in the very young group, and 3-year overall survival rate (94.3% versus. 96.8%, p = 0.10) was similar. Moreover, the 3-year overall survival rate (p = 0.020) and disease-free survival rate (p < 0.001) were significantly poorer in HR-positive patients in the very young group whereas there was no significant difference in outcomes between the HR-negative groups. In China, age younger than 35 years is an independent predictor of breast cancer recurrence. In very young women with HR-positive breast cancer, chemotherapy plus tamoxifen alone may not be adequate standard treatment. [ABSTRACT FROM AUTHOR]

A global consensus on carbon emission reductions has been reached for combating climate change. The Chinese government has clearly stated that it is necessary to make full use of market means to improve the level of environmental governance. Emissions trading scheme (ETS) is a typical market means to accelerate low-carbon economic transition. Low-carbon technological innovation is one of the key factors affecting carbon emissions. However, literature on the relationship between ETS and low-carbon technological innovation is relatively scarce at present. This study assesses the effect of pilot ETSs on low-carbon technological innovation, and a difference in differences (DID) model is adopted to analyze China's provincial panel data from 2003 to 2017. The results indicate that China's pilot ETSs can significantly promote low-carbon technological innovation, and changing the window period, PSM-DID and placebo test all verify the robustness of this finding. The dynamic effect test reveals that China's pilot ETSs will gradually increase the effect on low-carbon technological innovation over time. The heterogeneity analysis shows that the effect of China's pilot ETSs on low-carbon technological innovation is more obvious in Guangdong, Hubei, Tianjin and Chongqing. The mechanism analysis suggests that marketization degree and green consumption concept can positively moderate the impact of China's pilot ETSs on low-carbon technological innovation, and industrial structure upgrading plays a positive mediating role between China's pilot ETSs and low-carbon technological innovation. This study is conducive to assessing the policy effectiveness of China's pilot ETSs and provides an empirical evidence for promoting the development of the carbon emissions trading market. • China's pilot ETSs significantly improve low-carbon technological innovation. • China's pilot ETSs will gradually increase the effect on low-carbon technological innovation over time. • The policy effect of China's pilot ETSs is more obvious in Guangdong, Hubei, Tianjin and Chongqing. • Marketization degree and green consumption concept can positively moderate the policy effect of China's pilot ETSs. • China's pilot ETSs can promote low-carbon technological innovation by influencing industrial structure upgrading. [ABSTRACT FROM AUTHOR]

Abstract: The PAHs-degrading bacterium strain JY3A was newly isolated from the polluted soil in the Jinan Oil Refinery Factory, Shandong Province of China. The isolate was identified as Bacillus vallismortis with respect to its 16S rDNA sequence, DNA–DNA relatedness and fatty acid profiles, as well as various physiological characteristics. The strain was Gram-positive, motile, endospore forming, aerobic, oxidase and catalase-positive. The cells were 0.8–1.0μm wide and 2.0–2.5μm long, single or in pairs and sometimes in chains. Bacillus vallismortis strain JY3A could utilize naphthalene, phenanthrene, anthracene, pyrene, fluorene, benzene, toluene, phenol, methanol, ethanol, Tween 80, cyclohexane or catechol as sole carbon source. The strain alone removed 90.5% of pyrene at an initial concentration of 150ppm in 15days in the presence of 0.5% (w/w) Tween 80. However, in co-culture with Phanerochaete chrysosporium, JY3A reduced the concentration of pyrene by nearly 55.4% after 7days of incubation. [Copyright &y& Elsevier]

In drilling and completion conditions, subsea wellheads are exposed to enormous alternating bending moment loads from the riser due to complex environmental conditions, causing fatigue damage. The joint weld between the high-pressure (HP) wellhead and the casing is especially vulnerable to fatigue, creating the risk of operational failure and accidents. Although fatigue analysis is vital, the traditional S–N curve method is often not accurate enough. This paper proposed an analytical technique to examine subsea wellhead fatigue by combining subsea wellhead fatigue decoupled analysis with a nonlinear fatigue accumulation theoretical model. This method was used to assess subsea wellhead weld fatigue in a gas field in China's Bohai Sea during drilling and completion. The bending moment load spectrum at the top of the HP wellhead was obtained via global dynamic analysis. The bending moment-stress and bending moment-strain response curves of the welds were extracted using local quasi-static analysis. Finally, the theoretical nonlinear fatigue accumulation model and traditional S–N curve method were used to evaluate subsea wellhead weld fatigue, respectively. The results indicated that the fatigue damage caused by drilling was more significant than completion, while the fatigue damage at the weld between the HP wellhead and the 16″ casing exceeded that of the weld between the low-pressure (LP) housing and the 30″ conductor. Furthermore, the technique proposed in this paper could be used to assess more extensive fatigue damage than when employing the S–N curve method, indicating that the results were more conservative and more suitable for practical engineering applications. • A new method for solving the subsea wellhead weld's fatigue damage in drilling and completion was proposed. • The bending moment load spectrum of the top of the HP wellhead was obtained via global dynamic analysis. • The fatigue results obtained by the method proposed and traditional S–N curve method are compared. [ABSTRACT FROM AUTHOR]

Background: Febrile respiratory syndrome (FRS) is often associated with viral infections. The aim of this study was to identify the viral pathogens responsible for FRS in Liaoning Province, China., Methods: We tested eight respiratory viruses, namely, influenza virus (IFV), rhinovirus (RV), human adenovirus (HAdV), human bocavirus (HBoV), human parainfluenza virus (HPIV), human coronavirus (HCoV), respiratory syncytial virus (RSV), and human metapneumovirus (HMPV), using reverse transcription-polymerase chain reaction (RT-PCR). Statistical analyses were performed using SPSS version 25.0, and the data were plotted using RStudio 4.2.1 software., Results: IFV was the most frequently identified pathogen, followed by RV, HAdV, HBoV, HPIV, HCoV, RSV, and HMPV. RSV/HBoV coinfection occurred most frequently among the mixed cases. The rate of respiratory virus detection was highest in children under one year of age and decreased significantly with age. Seasonal trends showed a peak in virus detection during the winter months., Conclusions: IFV is the leading cause of FRS in Liaoning Province, China, with single-virus infections prevailing over coinfections. Observations indicate a differential virus detection rate across age groups and seasons, highlighting the need for focused preventive strategies to mitigate the transmission of respiratory viruses, particularly among susceptible populations in the colder season., (© 2024. The Author(s).)

Esophageal cancer is located in the 8th position of the incidence of malignant tumors and the 6th most common cause of cancer-related mortality in the world, while China has the highest incidence and mortality of esophageal cancer. Esophageal squamous cell carcinoma (ESCC), the predominant histologic type of esophageal cancer in China, accounts for about 90%. Despite recent improvement of surgical techniques and philosophy, however, the prognosis of ESCC patients treated with surgery is still poor, and 5-year survival remains unsatisfactorily low. So far, the pathogenesis of esophageal squamous cell carcinoma is still unclear, and effective prevention is also out of the question. To find the main factors affecting the prognosis of esophageal squamous cell carcinoma, and to improve the survival of patients, are the main directions of all scholars. Postoperative pathology of esophageal squamous cell carcinoma is considered to be one of the most important predictors of prognosis. Currently, the evaluation of postoperative esophageal prognosis mainly depends on TNM staging, but some criteria of its specific content and staging remains controversial. In this paper recent domestic and foreign related researches and clinical trials reports are collected, and the postoperative pathological features affecting esophageal squamous cell carcinoma prognosis were reviewed.

Recently, the dinucleotide variant ss469415590 (TT/ΔG) in a novel gene, interferon lambda 4 (IFNL4), was identified as a stronger predictor of hepatitis C virus (HCV) clearance in individuals of African ancestry compared with rs12979860. We aimed to determine whether this variant contributes to treatment decisions in a Chinese population. A total of 447 chronic hepatitis C (CHC) patients (including 328 treated with interferon alpha-2b and ribavirin), 129 individuals who had spontaneously cleared HCV (SHC), and 169 healthy controls were retrospectively investigated. ss469415590 genotyping was performed using a mass spectrometry method (SEQUENOM). A higher proportion of SHC individuals carried the TT/TT genotype compared with CHC patients (95.3% vs. 88.8%, P=0.027). In patients with HCV genotype 1b, the ss469415590 variant was independently associated with sustained virologic response (SVR) (odds ratio [OR]=3.247, 95% confidence interval [CI]=1.038-10.159, P=0.043) and on-treatment virological responses, including rapid (RVR), complete early (cEVR), early (EVR), and end-of-treatment (ETVR), with a minimal OR of 3.73. Especially for patients with high viral load (≥4×10(5) IU/ml), ΔG allele carriers had a lower chance of achieving SVR compared with those carrying the TT/TT genotype (7.1% vs. 36.0%, P=0.034, OR [95% CI]=7.24 [1.02-318.45], negative predictive value=92.9%). In patients with HCV genotype 2a, no significant association between the ss154949590 variant and the virological response was identified (P>0.05). Additionally, we found that ss154949590 was in complete linkage disequilibrium with rs12979860. In conclusion, the IFNL4 ss154949590 TT/TT genotype favors spontaneous clearance of HCV. This same variant is associated with treatment-induced clearance in patients with genotype 1b, but not 2a. ss469415590 (or rs12979860) genotyping should be considered for patients with HCV genotype 1b and high viral load when making a choice between standard dual therapy and an IFN-free direct-acting antiviral regimen., (Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.)

Hepatitis C virus (HCV) infections spontaneously clear in approximately 15-45% of infected individuals. Factors which influence spontaneous HCV clearance remain to be identified. The purpose of the present study was to identify variables associated with spontaneous HCV clearance in a referred population of Chinese patients. The prevalence of host, viral, and environmental factors known to influence the outcome of HCV infections was compared in 92 HCV spontaneous clearance subjects and 318 HCV persistent infection subjects. Univariate and multivariate analyses were performed to identify those factors associated with spontaneous HCV clearance. In univariate analysis, female gender, a history of icteric hepatitis, serologic evidence of concurrent HBV infection, and rs12979860 CC genotype were positively associated with spontaneous HCV clearance, while alcohol consumption was negatively associated with clearance. In multivariate analysis, female gender, a history of icteric hepatitis, concurrent HBV infection, and rs12979860 CC genotype remained independent variables associated with spontaneous HCV clearance. Spontaneous HCV clearance is more likely to occur in females, subjects with a history of icteric hepatitis, HBV coinfections, and those with the rs12979860 CC genotype.

Background: Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen, causing more than 200 cases of severe human infection worldwide, with the hallmarks of meningitis, septicemia, arthritis, etc. Very recently, SS2 has been recognized as an etiological agent for streptococcal toxic shock syndrome (STSS), which was originally associated with Streptococcus pyogenes (GAS) in Streptococci. However, the molecular mechanisms underlying STSS are poorly understood., Methods and Findings: To elucidate the genetic determinants of STSS caused by SS2, whole genome sequencing of 3 different Chinese SS2 strains was undertaken. Comparative genomics accompanied by several lines of experiments, including experimental animal infection, PCR assay, and expression analysis, were utilized to further dissect a candidate pathogenicity island (PAI). Here we show, for the first time, a novel molecular insight into Chinese isolates of highly invasive SS2, which caused two large-scale human STSS outbreaks in China. A candidate PAI of approximately 89 kb in length, which is designated 89K and specific for Chinese SS2 virulent isolates, was investigated at the genomic level. It shares the universal properties of PAIs such as distinct GC content, consistent with its pivotal role in STSS and high virulence., Conclusions: To our knowledge, this is the first PAI candidate from S. suis worldwide. Our finding thus sheds light on STSS triggered by SS2 at the genomic level, facilitates further understanding of its pathogenesis and points to directions of development on some effective strategies to combat highly pathogenic SS2 infections.